Recombinant Mouse Tgm2 Protein, Myc/DDK-tagged

• Cat.No.: Tgm2-6397M
• Product Overview: Purified recombinant protein of mouse full-length transglutaminase 2, C polypeptide (Tgm2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 77.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tgm2 transglutaminase 2, C polypeptide [ Mus musculus (house mouse) ]
• Official Symbol: Tgm2
• Synonyms: TGM2; transglutaminase 2, C polypeptide; protein-glutamine gamma-glutamyltransferase 2; TGC; TG C; TG(C); TGase C; TGase-2; C polypeptide; transglutaminase C; transglutaminase-2; tissue transglutaminase; protein-glutamine-gamma-glutamyltransferase; TG2; tTG; G[a]h; tTGas; TGase2
• Gene ID: 21817
• mRNA Refseq: NM_009373
• Protein Refseq: NP_033399
• UniProt ID: P21981

Reviews

12/21/2020

The TGM2 protein has demonstrated its efficacy in protein electron microscopy structure analysis.

03/30/2020

Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

07/19/2018

This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

Q&As

Are there diagnostic applications of TGM2 in clinical settings?

TGM2 levels and activity can serve as diagnostic markers in certain conditions, providing insights into the progression and severity of diseases.

How does TGM2 influence cardiovascular health?

TGM2 has been associated with cardiovascular diseases, contributing to the development of atherosclerosis and vascular calcification.

How does TGM2 contribute to fibrosis in organ tissues?

TGM2 plays a role in fibrosis by promoting the cross-linking of extracellular matrix proteins, contributing to tissue stiffness and impaired organ function.

How does TGM2 affect inflammation and immune responses?

TGM2 is involved in modulating inflammation and immune responses, influencing processes such as cytokine production and leukocyte adhesion.

Are there genetic mutations related to TGM2 that impact clinical outcomes?

Genetic variations in TGM2 have been identified, and certain mutations may influence susceptibility to specific diseases or alter the enzyme's functionality.