Recombinant Mouse Thap1 Protein, Myc/DDK-tagged

• Cat.No.: Thap1-6404M
• Product Overview: Purified recombinant protein of mouse full-length THAP domain containing, apoptosis associated protein 1 (Thap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 24.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Thap1 THAP domain containing, apoptosis associated protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Thap1
• Synonyms: THAP1; THAP domain containing, apoptosis associated protein 1; THAP domain-containing protein 1; AW490810; 4833431A01Rik
• Gene ID: 73754
• mRNA Refseq: NM_199042
• Protein Refseq: NP_950243
• UniProt ID: Q8CHW1