Recombinant Mouse Tiprl Protein, Myc/DDK-tagged

• Cat.No.: Tiprl-6439M
• Product Overview: Purified recombinant protein of mouse full-length TIP41, TOR signalling pathway regulator-like (S. cerevisiae) (Tiprl), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
• Molecular Mass: 31.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tiprl TIP41, TOR signalling pathway regulator-like (S. cerevisiae) [ Mus musculus (house mouse) ]
• Official Symbol: Tiprl
• Synonyms: TIPRL; TIP41, TOR signalling pathway regulator-like (S. cerevisiae); TIP41-like protein; 1810011K17Rik
• Gene ID: 226591
• mRNA Refseq: NM_145513
• Protein Refseq: NP_663488
• UniProt ID: Q8BH58