Recombinant Mouse TMPRSS6 Protein (81-811 aa), His-Myc-tagged

• Cat.No.: TMPRSS6-2746M
• Product Overview: Recombinant Mouse TMPRSS6 Protein (81-811 aa) is produced by Baculovirus expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Cell Biology. Protein Description: Partial.

Specification

• Description: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.
• Source: Baculovirus
• Species: Mouse
• Tag: His-Myc
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 86.1 kDa
• Protein length: 81-811 aa
• AA Sequence: KAEVTVSQVYSGSLRVLNRHFSQDL GRRESIAFRSESAKAQKMLQELVAS TRLGTYYNSSSVYSFGEGPLTCFFW FILDIPEYQRLTLSPEVVRELLVDE LLSNSSTLASYKTEYEVDPEGLVIL EASVNDIVVLNSTLGCYRYSYVNPG QVLPLKGPDQQTTSCLWHLQGPEDL MIKVRLEWTRVDCRDRVAMYDAAGP LEKRLITSVYGCSRQEPVMEVLASG SVMAVVWKKGMHSYYDPFLLSVKSV AFQDCQVNLTLEGRLDTQGFLRTPY YPSYYSPSTHCSWHLTVPSLDYGLA LWFDAYALRRQKYNRLCTQGQWMIQ NRRLCGFRTLQPYAERIPMVASDGV TINFTSQISLTGPGVQVYYSLYNQS DPCPGEFLCSVNGLCVPACDGIKDC PNGLDERNCVCRAMFQCQEDSTCIS LPRVCDRQPDCLNGSDEEQCQEGVP CGTFTFQCEDRSCVKKPNPECDGQS DCRDGSDEQHCDCGLQGLSSRIVGG TVSSEGEWPWQASLQIRGRHICGGA LIADRWVITAAHCFQEDSMASPKLW TVFLGKMRQNSRWPGEVSFKVSRLF LHPYHEEDSHDYDVALLQLDHPVVY SATVRPVCLPARSHFFEPGQHCWIT GWGAQREGGPVSNTLQKVDVQLVPQ DLCSEAYRYQVSPRMLCAGYRKGKK DACQGDSGGPLVCREPSGRWFLAGL VSWGLGCGRPNFFGVYTRVTRVINW IQQVLT
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Tmprss6 transmembrane serine protease 6 [ Mus musculus ]
• Official Symbol: TMPRSS6
• Synonyms: TMPRSS6; matriptase 2; matriptase-2; type II transmembrane serine protease 6; 1300008A22Rik
• Gene ID: 71753
• mRNA Refseq: NM_027902
• Protein Refseq: NP_082178
• UniProt ID: Q9DBI0