Recombinant Mouse Tph1 Protein, Myc/DDK-tagged

• Cat.No.: Tph1-6594M
• Product Overview: Purified recombinant protein of mouse full-length tryptophan hydroxylase 1 (Tph1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 51.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tph1 tryptophan hydroxylase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Tph1
• Synonyms: TPH1; tryptophan hydroxylase 1; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1; Tph
• Gene ID: 21990
• mRNA Refseq: NM_009414
• Protein Refseq: NP_033440
• UniProt ID: P17532