Recombinant Mouse Ttll12 Protein, Myc/DDK-tagged

• Cat.No.: Ttll12-6723M
• Product Overview: Purified recombinant protein of mouse full-length tubulin tyrosine ligase-like family, member 12 (Ttll12), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 74 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ttll12 tubulin tyrosine ligase-like family, member 12 [ Mus musculus (house mouse) ]
• Official Symbol: Ttll12
• Synonyms: TTLL12; tubulin tyrosine ligase-like family, member 12; tubulin--tyrosine ligase-like protein 12; TTL domain protein; BC055368; D430005B17
• Gene ID: 223723
• mRNA Refseq: NM_183017
• Protein Refseq: NP_898838
• UniProt ID: Q3UDE2