Recombinant Mouse Uvssa Protein, Myc/DDK-tagged

• Cat.No.: Uvssa-6887M
• Product Overview: Purified recombinant protein of mouse full-length UV stimulated scaffold protein A (Uvssa), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 81.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Uvssa UV stimulated scaffold protein A [ Mus musculus (house mouse) ]
• Official Symbol: Uvssa
• Synonyms: Uvssa; UV stimulated scaffold protein A; Kiaa1530; mKIAA1530; 4933407H18Rik; D330017J19Rik; UV-stimulated scaffold protein A
• Gene ID: 71101
• mRNA Refseq: NM_001081101
• Protein Refseq: NP_001074570
• UniProt ID: Q9D479