- Human(4)
- Mouse(2)
- Rat(1)
- Rhesus Macaque(1)
- Zebrafish(1)
Recombinant Mouse Vps26a Protein, Myc/DDK-tagged
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Cat.No. : | Vps26a-6932M |
Product Overview : | Purified recombinant protein of Mouse VPS26 retromer complex component A (Vps26a), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
Description : | Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 38.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Vps26a VPS26 retromer complex component A [ Mus musculus (house mouse) ] |
Official Symbol : | Vps26a |
Synonyms : | VPS26A; vacuolar protein sorting 26 homolog A (yeast); vacuolar protein sorting-associated protein 26A; mVPS26; H beta 58; h< beta> 58 protein; vacuole protein sorting 26; vesicle protein sorting 26A; HB58; Vps26; AA407240; |
Gene ID : | 30930 |
mRNA Refseq : | NM_133672 |
Protein Refseq : | NP_598433 |
UniProt ID : | P40336 |
◆ Recombinant Protein
VPS26A-200H | Recombinant Human VPS26A Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
VPS26A-5167R | Recombinant Rhesus monkey VPS26A Protein, His-tagged | +Inquiry |
VPS26A-6541R | Recombinant Rat VPS26A Protein | +Inquiry |
VPS26A-11149Z | Recombinant Zebrafish VPS26A | +Inquiry |
VPS26A-3673H | Recombinant Human VPS26A, His-tagged | +Inquiry |
|
◆ Lysates
VPS26A-394HCL | Recombinant Human VPS26A 293 Cell Lysate | +Inquiry |
|
VPS28 VPS29 VPS24 VPS11 VPS18 VPS25 VPS72 VPS8 VPS16 VPS26A VPS35 VPS33B VPS13A VPS33A VPS36 VPS37C VPS45 VPS4A VPS4B VPS52 VPS53 VPS39 VPS41 VPS37A VPS26B VPS37B VPS37D VPS13D VPS13B VPS13C VPS51 Vps54
Easy access to products and services you need from our library via powerful searching tools.
Copyright © 2022 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy