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Recombinant Mouse Washc1 Protein, Myc/DDK-tagged

Cat.No. : Washc1-6964M
Product Overview : Purified recombinant protein of Mouse WASH complex subunit 1 (Washc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Acts as component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 52.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Washc1 WASH complex subunit 1 [ Mus musculus (house mouse) ]
Official Symbol : Washc1
Synonyms : Washc1; WASH complex subunit 1; Wa; Was; Wash; ORF19; Wash1; 1110049F14Rik; WASH complex subunit 1; WAS protein family homolog 1
Gene ID : 68767
mRNA Refseq : NM_026833
Protein Refseq : NP_081109
UniProt ID : Q8VDD8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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