Recombinant Mouse Wdr26 Protein, Myc/DDK-tagged
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Cat.No. : | Wdr26-6976M |
Product Overview : | Purified recombinant protein of Mouse WD repeat domain 26 (Wdr26), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
Description : | G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria. Protects also cells by promoting hypoxia-mediated autophagy and mitophagy. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 70.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Wdr26 WD repeat domain 26 [ Mus musculus (house mouse) ] |
Official Symbol : | Wdr26 |
Synonyms : | WDR26; WD repeat domain 26; WD repeat-containing protein 26; C77982; AA693241; AI447817; AU044014; 1600024A01Rik |
Gene ID : | 226757 |
mRNA Refseq : | NM_145514 |
Protein Refseq : | NP_663489 |
UniProt ID : | Q8C6G8 |
◆ Recombinant Protein
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WDR26-3950H | Recombinant Human WDR26 protein, His-tagged | +Inquiry |
WDR26-18461M | Recombinant Mouse WDR26 Protein | +Inquiry |
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WDR4 WDR5 WDR6 WDR20 WDR61 WDR77 WDR13 WDR36 WDR42A WDR79 WDR41 WDR45L WDR87 WDR88 WDR89 WDR18 WDR70 WDR73 WDR74 WDR75 WDR76 WDR46 WDR49 WDR26 WDR27 WDR3 WDR19 WDR31 WDR33 WDR35 WDR37 WDR44 WDR45 WDR54 WDR59 WDR5B WDR62 WDR65 WDR66 WDR11 WDR12 WDR16 WDR1 WDR78 WDR8 WDR85 WDR86 WDR91 WDR53 WDR92 WDR17 WDR24 WDR25 WDR43 WDR47 WDR48 WDR60 WDR63 WDR64 WDR69 Wdr20a WDR52 WDR81 WDR83OS WDR83 WDR90 WDR93 WDR82 Wdr95 Wdr20b Wdr25l WDR34 Wdr35l Wdr38 Wdr55 Wdr67 Wdr7 Wdr72 Wdr96
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