Recombinant Mouse Wdr26 Protein, Myc/DDK-tagged

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Recombinant Mouse Wdr26 Protein, Myc/DDK-tagged

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Cat.No. : Wdr26-6976M
Product Overview : Purified recombinant protein of Mouse WD repeat domain 26 (Wdr26), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria. Protects also cells by promoting hypoxia-mediated autophagy and mitophagy.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 70.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Wdr26 WD repeat domain 26 [ Mus musculus (house mouse) ]
Official Symbol : Wdr26
Synonyms : WDR26; WD repeat domain 26; WD repeat-containing protein 26; C77982; AA693241; AI447817; AU044014; 1600024A01Rik
Gene ID : 226757
mRNA Refseq : NM_145514
Protein Refseq : NP_663489
UniProt ID : Q8C6G8
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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