Recombinant Ovine CXCL10 (IP-10)
Cat.No. : | CXCL10-50O |
Product Overview : | Ovine CXCL10/IP-10 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
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Description : | C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is a member of the C-X-C chemokine family. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3. |
Source : | Yeast |
Species : | Ovine |
Form : | Lyophilized |
Molecular Mass : | 9.4 kDa |
AA Sequence : | IPLSRNTRCT CIEISNGSVN PRSLEKLELI PASQSCPRVE IIATMKRNGE KRCLNPESKT IKNLLKAINK QRTKRSPRTQ KEA (83) |
Applications : | The Ovine CXCL10/IP-10 protein can be used in cell culture, as an CXCL10/IP-10 ELISA Standard, and as a Western Blot Control. |
Storage : | -20 C |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCXCL10 affects the blood-brain barrier, playing a role in neuroinflammatory disorders.
CXCL10 plays a role in autoimmune diseases, exacerbating conditions like rheumatoid arthritis and lupus.
In cancer, CXCL10 influences the tumor microenvironment and may contribute to tumor spread and metastasis.
Changes in CXCL10 expression influence chronic inflammatory diseases, potentially aggravating or modulating disease progression.
CXCL10 is important in antiviral defense, enhancing immune responses against pathogens like hepatitis viruses and HIV.
CXCL10 impacts angiogenesis and is involved in tissue repair and regeneration processes.
CXCL10 attracts and activates immune cells to sites of inflammation and infection, coordinating the immune response.
Customer Reviews (3)
Write a reviewExpertise in protein engineering, invaluable for our laboratory's needs.
Swift protein characterization services, essential for our research projects.
High-quality protein-protein interaction assays, integral to our experiments.
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