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Recombinant Pig IL1RN protein

Cat.No. : IL1RN-89P
Product Overview : Recombinant Pig IL1RN protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Source : E.coli
Species : Pig
Form : Lyophilized from a 0.2μm filtered concentrated solution in 1 × PBS, pH 7.4, 1 mM DTT.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 10⁴ IU/mg in the presence of 75 pg/ml rPoIL-1α.
Molecular Mass : Approximately 17.1 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids.
Protein length : 152
AA Sequence : HPLGKRPCRMQAFRIWDVNQKTFYL RNNQLVAGYLQGPNTKLEEKIDVVP VEPHFVFLGIHGGKLCLSCVKSGDE MKLQLDAVNITDLRKNSEQDKRFTF IRSDSGPTTSFESAACPGWFLCTAL EADQPVGLTNTPKAAVKVTKFYFQQ DQ
Endotoxin : Less than 0.1 EU/µg of rPoIL-1RA as determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : IL1RN
Official Symbol : IL1RN
Synonyms : IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL-1ra; IL1 inhibitor; IRAP1;
Gene ID : 397499
mRNA Refseq : NM_214262
Protein Refseq : NP_999427
UniProt ID : Q29056

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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