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Recombinant Rat ADPRM Protein

Cat.No. : ADPRM-538R
Product Overview : Recombinant Rat ADPRM full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent [ Rattus norvegicus ]
Official Symbol : ADPRM
Gene ID : 287406
mRNA Refseq : NM_001009246.1
Protein Refseq : NP_001009246.1
MIM :
UniProt ID : Q5M886

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Can ADPRM proteins be used as a diagnostic tool for cancer? 06/15/2022

ADPRM proteins have been identified as potential biomarkers for certain types of cancer. For example, high levels of ADPRM expression have been observed in ovarian cancer, and this may be used as a diagnostic marker or a target for therapy.

How are PARP inhibitors used in cancer treatment? 04/14/2022

PARP inhibitors are a class of drugs that are used in cancer treatment, particularly in the treatment of breast and ovarian cancer. PARP inhibitors work by blocking the activity of ADPRM proteins, which are critical for the repair of single-strand DNA breaks. In cancer cells that have defective DNA repair pathways, such as those with BRCA mutations, PARP inhibitors result in the accumulation of single-strand DNA breaks, leading to cell death.

How are ADPRM proteins related to autoimmune diseases? 06/08/2021

ADPRM proteins have been found to play a role in the regulation of immune responses, and there is evidence to suggest that dysfunction or dysregulation of these proteins may contribute to the development of autoimmune diseases. For example, studies have shown that ADPRM proteins are involved in regulating the activation and differentiation of immune cells, and that aberrant ADPRM activity may contribute to the production of autoantibodies and the development of systemic lupus erythematosus (SLE).

Can mutations in ADPRM genes cause disease? 04/25/2021

Yes, mutations in ADPRM genes have been associated with several diseases, including cancer and neurodegenerative disorders. Loss-of-function mutations in ADPRM genes can result in defective DNA repair pathways, leading to increased susceptibility to cancer and possibly other diseases. Additionally, mutations in ADPRM genes have been linked to neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, although the mechanisms underlying these associations are not fully understood.

Are there any other medical applications for ADPRM proteins? 05/14/2020

Beyond cancer treatment, ADPRM proteins are also being investigated for their potential to treat other diseases such as neurodegenerative diseases, inflammation, and diabetes.

Are there any side effects associated with PARP inhibitors? 04/01/2020

Like all medications, PARP inhibitors can have side effects. Common side effects include fatigue, nausea, vomiting, and low blood cell counts. However, these side effects are generally less severe than those associated with traditional chemotherapy.

How do ADPRM proteins interact with other DNA repair proteins? 06/16/2019

ADPRM proteins interact with other DNA repair proteins in a complex network of interactions that are critical for the repair of damaged DNA. For example, ADPRM proteins have been shown to interact with BRCA proteins, which play a crucial role in DNA repair and are frequently mutated in certain types of cancer. ADPRM proteins may also interact with other proteins involved in DNA damage response pathways such as APE1, XRCC1, and DNA pol β.

How are ADPRM proteins involved in DNA repair? 06/14/2019

ADPRM proteins play a crucial role in the repair of damaged DNA through a process called base excision repair (BER). When DNA is damaged, a PARP enzyme binds to the damaged site and recruits other proteins to repair the damage.

Are there any genetic diseases related to ADPRM proteins? 03/16/2019

Yes, there are genetic diseases related to ADPRM proteins. One such disease is familial breast cancer, which can be caused by mutations in the BRCA1 and BRCA2 genes. These genes play a role in DNA repair and are involved in the regulation of ADPRM proteins.

Can ADPRM proteins be targeted for therapeutic purposes? 01/21/2019

Yes, ADPRM proteins have emerged as promising targets for therapeutic intervention, particularly in the treatment of cancer. PARP inhibitors, which target ADPRM proteins, have shown efficacy in treating certain types of cancer, most notably breast and ovarian cancer. Additionally, targeting ADPRM proteins may have potential in other disease contexts, such as in neurodegenerative disorders.

Are there any drugs that target ADPRM proteins besides PARP inhibitors? 07/24/2017

Yes, other drugs have been developed that target ADPRM proteins besides PARP inhibitors. For example, ADPRM inhibitors that target the catalytic domain of the protein have been developed and are being tested as potential cancer therapeutics. Additionally, drugs that modulate the activity of ADPRM proteins by regulating their automodification or interactions with other proteins are also being investigated as potential therapeutic approaches.

Are there any side effects associated with PARP inhibitors? 05/14/2017

Like all drugs, PARP inhibitors can have side effects. Common side effects include fatigue, nausea, vomiting, and anemia. More serious side effects, such as allergic reactions and neurological toxicity, are less common but can occur. It is important for patients receiving PARP inhibitors to be monitored closely by their healthcare provider for any adverse reactions.

Are there any drugs that target ADPRM proteins? 01/09/2017

Yes, PARP inhibitors are a class of drugs that target ADPRM proteins. These inhibitors are being used in the treatment of some types of cancer, particularly those that are caused by defects in DNA repair mechanisms.

How do PARP inhibitors work? 05/30/2016

PARP inhibitors work by blocking the activity of ADPRM proteins. This prevents the repair of damaged DNA, which can be lethal to cancer cells that are already genetically unstable. PARP inhibitors are often used in combination with chemotherapy in cancer treatment.

Customer Reviews (5)

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Reviews
09/12/2022

    I wouldn't hesitate to use this product again or recommend it to other researchers looking for reliable and high-quality proteins.

    01/24/2021

      From the available information, it appears that ADPRM protein has been linked to various diseases, making it a potentially important target for research.

      06/20/2019

        To ensure the quality of the product, it's recommended to carefully review the product specifications and technical support provided by the manufacturer.

        12/21/2017

          Based on my understanding of ADPRM protein, I can say that obtaining a high-quality product is crucial for accurate and reliable research results.

          05/02/2016

            It has exceeded my expectations and has helped me carry out my experiments smoothly and efficiently.

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