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Recombinant Rat Aif1 Protein, His-tagged

Cat.No. : Aif1-509R
Product Overview : Recombinant Rat Aif1(Met1~Pro147) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Source : E. coli
Species : Rat
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 18.3kDa
Protein length : Met1~Pro147
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : Aif1 allograft inflammatory factor 1 [ Rattus norvegicus ]
Official Symbol : Aif1
Synonyms : AIF1; allograft inflammatory factor 1; protein BART-1; AIF-1; microglia response factor; balloon angioplasty responsive transcript; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; balloon angioplasty-responsive transcript 1; iba1; Bart1; mrf-1;
Gene ID : 29427
mRNA Refseq : NM_017196
Protein Refseq : NP_058892
UniProt ID : P55009

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Does AIF1 have any role in cardiovascular diseases? 05/20/2023

Yes, AIF1 has been implicated in cardiovascular diseases, particularly in atherosclerosis, a condition in which plaque builds up in the arteries. AIF1 is involved in the activation of macrophages, which play a key role in the development of atherosclerosis. AIF1 expression has been found to be increased in atherosclerotic plaques.

Can AIF1 be used for gene therapy? 12/04/2022

AIF1 has not been widely studied as a potential target for gene therapy. However, it is possible that its role in immune cell activation and inflammation could be harnessed for therapeutic purposes.

Can AIF1 be used as a biomarker for disease diagnosis? 05/30/2022

AIF1 has been suggested as a potential biomarker for several diseases, including Alzheimer's disease and multiple sclerosis. However, more research is needed to validate its use as a diagnostic biomarker.

Is there any genetic variation in the AIF1 gene? 03/06/2022

Yes, there are genetic variations in the AIF1 gene that have been associated with various diseases. For example, a single nucleotide polymorphism (SNP) in the AIF1 gene has been linked to an increased risk of rheumatoid arthritis, while another SNP has been associated with autoimmune thyroid disease.

What are the different isoforms of AIF1? 02/11/2022

There are three known isoforms of AIF1: AIF1α, AIF1β, and AIF1γ. AIF1α is the most well-known isoform and is expressed in macrophages, microglia, and other immune cells. AIF1β is expressed in the thymus and spleen, while AIF1γ is expressed in the testis.

Can AIF1 be used as a biomarker for any diseases? 03/23/2021

AIF1 has been proposed as a potential biomarker for various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. However, more research is needed to establish its usefulness as a biomarker and determine the best way to measure AIF1 levels.

What are the potential clinical applications of AIF1? 11/02/2020

AIF1 is a potential target for the development of therapies for various diseases, including Alzheimer's disease, multiple sclerosis, and cancer. It could also be used as a diagnostic biomarker for certain diseases.

Is AIF1 involved in neuroinflammation and neurodegenerative diseases? 06/04/2020

Yes, AIF1 is involved in neuroinflammation and neurodegenerative diseases. It is expressed in microglia, the immune cells of the central nervous system (CNS), and plays a role in activating these cells and promoting neuroinflammation. Increased AIF1 expression has been observed in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

What are some potential therapeutic strategies for targeting AIF1? 09/18/2019

Potential therapeutic strategies for targeting AIF1 include developing drugs that inhibit its expression or function, or developing immunomodulatory therapies that modulate immune cell activation more broadly. However, more research is needed to determine the feasibility and safety of these approaches.

How is AIF1 protein detected in cells? 11/22/2018

AIF1 protein can be detected in cells using various techniques, including immunohistochemistry, immunofluorescence, Western blotting, and flow cytometry. Antibodies that specifically recognize AIF1 can be used to visualize its expression and localization within cells.

Can AIF1 be targeted therapeutically? 10/06/2018

AIF1 is a potential target for therapeutic interventions aimed at reducing inflammation in various diseases. However, more research is needed to develop effective therapies that specifically target AIF1.

Are there any known mutations in the AIF1 gene that cause disease? 07/06/2017

There are currently no known mutations in the AIF1 gene that cause disease, although genetic variation in the gene may influence susceptibility to certain diseases.

Are there any drugs that target AIF1? 07/15/2015

There are currently no drugs that specifically target AIF1, although some drugs that target immune cells, such as corticosteroids and immunosuppressive agents, may indirectly affect AIF1 expression and function.

Is AIF1 involved in cancer? 07/01/2015

AIF1 has been found to be overexpressed in several types of cancer, including breast cancer, pancreatic cancer, and esophageal cancer. Its exact role in cancer is not yet fully understood, but it is thought to play a role in tumor progression and metastasis.

Customer Reviews (4)

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Reviews
11/06/2022

    Whether I require assistance with troubleshooting experimental protocols or guidance on data analysis, their reliable and prompt support will undoubtedly prove invaluable in finding solutions.

    10/06/2020

      The AIF1 protein displays exceptional quality and is precisely aligned with my experimental requirements.

      06/08/2020

        Its reliability and the manufacturer's expertise will undoubtedly contribute to the success and significance of my research.

        06/24/2019

          the AIF1 protein's remarkable quality and the manufacturer's excellent technical support make it an ideal choice to fulfill my experimental needs.

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