Recombinant Rat C4b Protein, His-tagged
Cat.No. : | C4b-342R |
Product Overview : | Recombinant Rat C4b Protein (Ala1477-Val1737) with N-His tag was expressed in E. coli. |
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- Gene Information
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Description : | Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Predicted to be involved in complement activation; detection of molecule of bacterial origin; and positive regulation of apoptotic cell clearance. Predicted to act upstream of or within immunoglobulin mediated immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to human C4B (complement C4B (Chido blood group)). |
Source : | E. coli |
Species : | Rat |
Tag : | N-His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 33.2 kDa Accurate Molecular Mass: 33 kDa |
Protein length : | Ala1477-Val1737 |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | C4b complement component 4B (Chido blood group) [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | C4b |
Synonyms : | C4B; complement component 4B (Chido blood group); complement component 4, gene 2; complement C4-like protein; C4l; C4-2 |
Gene ID : | 406161 |
mRNA Refseq : | NM_001002805 |
Protein Refseq : | NP_001002805 |
UniProt ID : | Q6MG90 |
Products Types
◆ Recombinant Protein | ||
C4B-0051H | Recombinant Human C4B Protein, GST-Tagged | +Inquiry |
C4B-340H | Recombinant Human C4B Protein, His-tagged | +Inquiry |
C4B-343H | Recombinant Human C4B Protein, His-tagged | +Inquiry |
C4b-0053M | Recombinant Mouse C4b Protein, GST-Tagged | +Inquiry |
C4B-1147M | Recombinant Mouse C4B Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
C4B-99H | Native Human C4b Binding Protein | +Inquiry |
C4B-10H | Native Human C4B Protein | +Inquiry |
C4B-1846H | Native Human C4B Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionC4B inhibitors can be used to treat diseases associated with complement hyperactivation, such as autoimmune diseases and graft-versus-host disease. By inhibiting the activity of C4B, it is possible to attenuate the excessive inflammatory response and tissue damage.
The expression level of C4B is regulated by a variety of factors, including inflammatory factors, cytokines, and drugs. These factors can affect the synthesis and release of C4B, thus affecting its function in the immune system.
It can bind to other complement components and immunoglobulins to form immune complexes. These immune complexes can be recognized and cleared by clearance mechanisms in the body, such as phagocytes.
It is closely related to other immune system components (such as T cells, B cells, antibodies, etc.) and is involved in the immune defense response in the body. The interactions and influences between them are important for maintaining immune homeostasis.
The role of C4B in different types of cells may vary. For example, in immune cells, it can be involved in the regulation of immune responses and cell activation, while in endothelial cells, it may be involved in the process of vascular inflammation and injury.
C4B interacts with other complement components (e.g., C4A, C2, C3, etc.) to form part of the complement activation pathway and is involved in the immune defense response.
Customer Reviews (3)
Write a reviewC4B labeling works very well and can be fluorescently labeled, etc., which is very suitable for our research.
In experiments, biocompatibility showed up very well.
Very good at western-blot experimenting.
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