Recombinant Rat CD300LF Protein (19-181 aa), His-SUMO-Myc-tagged


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Recombinant Rat CD300LF Protein (19-181 aa), His-SUMO-Myc-tagged

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Cat.No. : CD300LF-2259R
Product Overview : Recombinant Rat CD300LF Protein (19-181 aa) is produced by E. coli expression system. This protein is fused with a 10xHis-SUMO tag at the N-terminal and a Myc tag at the C-terminal. Protein Description: Partial.
Description : Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.
Source : E. coli
Species : Rat
Tag : His-SUMO-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 38.3 kDa
Protein length : 19-181 aa
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : Cd300lf Cd300 molecule-like family member F [ Rattus norvegicus ]
Official Symbol : CD300LF
Synonyms : CD300LF; CMRF35-like molecule 1; CLM-1; CD300 antigen like family member F; CD300f; RGD1309733;
Gene ID : 287818
mRNA Refseq : NM_001025111
Protein Refseq : NP_001020282
UniProt ID : Q566E6
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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