Recombinant Rat CD300LF Protein (19-181 aa), His-SUMO-Myc-tagged
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| Cat.No. : | CD300LF-2259R |
| Product Overview : | Recombinant Rat CD300LF Protein (19-181 aa) is produced by E. coli expression system. This protein is fused with a 10xHis-SUMO tag at the N-terminal and a Myc tag at the C-terminal. Protein Description: Partial. |
| Description : | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
| Source : | E. coli |
| Species : | Rat |
| Tag : | His-SUMO-Myc |
| Form : | Tris-based buffer,50% glycerol |
| Molecular Mass : | 38.3 kDa |
| Protein length : | 19-181 aa |
| AA Sequence : | AQDPVTGPEEVSGYE QGSLTVWCRYGSWWK DYSKYWCRGPKRSSC EIRVETDASERLVKE NHVSIRDDQTNFTFT VTMEDLRMSDAGIYW CGITKAGYDHMFKVH VSINPVPTTPTTTST TTIFTVTTTVKETST LSTQTSHYSDNRYDS GGVGDGNGFLDLS |
| Purity : | > 90% as determined by SDS-PAGE. |
| Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
| Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
| Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
| Figure : |
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. |
| Gene Name : | Cd300lf Cd300 molecule-like family member F [ Rattus norvegicus ] |
| Official Symbol : | CD300LF |
| Synonyms : | CD300LF; CMRF35-like molecule 1; CLM-1; CD300 antigen like family member F; CD300f; RGD1309733; |
| Gene ID : | 287818 |
| mRNA Refseq : | NM_001025111 |
| Protein Refseq : | NP_001020282 |
| UniProt ID : | Q566E6 |
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Cd14Cd180Cd19CD1ACD1DCd1d1Cd2CD200CD200R1CD200R1LCd200r4CD209Cd209bCD22CD226CD24CD244Cd27CD274CD28CD32BCD33CD34Cd36CD38CD3DCD3ECD4CD40CD40LGCD44CD48CD5CD52CD55CD58Cd5lCD6CD68CD69CD7CD70CD74Cd80CD84CD86CD89CD8ACD97Cd99Cd99l2CD9CD177CD300ACD59CD37Cd24aCD63Cd209aCD46CD247CD2ACD300CCD72CD79ACD79BCD81CD83CD96CD163CD160CD164CD276CD82CD151CD1BCD1CCD248CD3EAPCD3GCD47CD53CD8BCD93CD1CD101CD109CD139CD165CD207CD300ECD300LFCD8B1CD163L1Cd1b3CD1ECD2BP2CD1021CD2APCd200r3CD302CD300LDCD300LGCD164L2Cd1d2Cd200r2CD300LBCd300lhCd300le-ps1CD320Cd59aCd59bCd209cCd209dCd209eCd209fCD166CD147CD144CD66aCD66eCD66cCD40LCD26CD95CD64CD32aCD16aCD32CD49eCD119CD118CD146CD10CD155CD62LCD150
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