Recombinant Rat Clec2d protein(Lys98-Leu233), hFc-tagged

• Cat.No.: Clec2d-547R
• Product Overview: Recombinant Rat CLEC2D (NP_569086.1) (Lys98-Leu233) was expressed in HEK293 with Fc region of Human IgG1 at the N-terminus.

Specification

• Source: HEK293
• Species: Rat
• Tag: Fc
• Protein length: Lys98-Leu233
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant rat CLEC2D comprises 396 amino acids and predicts a molecular mass of 44 kDa. The apparent molecular mass of the recombinant protein is approximately 44-54 and 36 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Clec2d C-type lectin domain family 2, member D [ Rattus norvegicus ]
• Official Symbol: Clec2d
• Synonyms: CLEC2D; C-type lectin domain family 2, member D; C-type lectin domain family 2 member D5; osteoclast inhibitory lectin; Ocil; Clec2d5
• Gene ID: 113937
• mRNA Refseq: NM_130402
• Protein Refseq: NP_569086

Reviews

06/24/2021

Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.

08/29/2020

This flexibility enables researchers like myself to tailor CLEC2D protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.

11/08/2018

The CLEC2D protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

Q&As

How does HLA-DMA contribute to the development of vaccines?

HLA-DMA's role in antigen presentation is relevant to vaccine development, as it impacts the immune response generated by vaccines and influences the effectiveness of vaccination strategies.

In transplantation, how does HLA-DMA impact graft acceptance or rejection?

Understanding HLA-DMA's role is crucial in transplantation, as it affects the presentation of antigens from the graft, influencing the immune response and the likelihood of graft acceptance or rejection.

How does HLA-DMA contribute to the adaptive immune response?

HLA-DMA facilitates the loading of antigenic peptides onto MHC class II molecules, a process essential for the activation of CD4+ T cells and the adaptive immune response.

How does HLA-DMA relate to autoimmune diseases?

Aberrant antigen presentation mediated by HLA-DMA has been implicated in autoimmune diseases, as it may lead to the presentation of self-antigens and the activation of autoreactive T cells.

Can HLA-DMA be used as a biomarker in disease diagnosis?

Abnormalities in HLA-DMA expression or function may serve as biomarkers in disease diagnosis, providing insights into the dysregulation of antigen presentation pathways.