Recombinant Human CLEC2D protein, mFc-tagged

• Cat.No.: CLEC2D-327H
• Product Overview: Recombinant Human CLEC2D protein(Q9UHP7-1)(Arg 60 - Val 191) is expressed from human 293 cells (HEK293).

Specification

• Source: HEK293
• Species: Human
• Tag: mFc
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
• Molecular Mass: The protein has a calculated MW of 42.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: Arg 60 - Val 191
• Endotoxin: Less than 0.1 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20°C to -70°C for 12 months in lyophilized state;
  -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: CLEC2D C-type lectin domain family 2, member D [ Homo sapiens ]
• Official Symbol: CLEC2D
• Synonyms: CLEC2D; C-type lectin domain family 2, member D; C type lectin superfamily 2, member D; C-type lectin domain family 2 member D; C type lectin related f; CLAX; lectin like transcript 1; LLT1; OCIL; LLT-1; C-type lectin related f; lectin-like transcript 1; lectin-like NK cell receptor; osteoclast inhibitory lectin; C-type lectin superfamily 2, member D
• Gene ID: 29121
• mRNA Refseq: NM_001004419
• Protein Refseq: NP_001004419
• MIM: 605659
• UniProt ID: Q9UHP7

Reviews

06/24/2021

Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.

08/29/2020

This flexibility enables researchers like myself to tailor CLEC2D protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.

11/08/2018

The CLEC2D protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

Q&As

How does HLA-DMA contribute to the development of vaccines?

HLA-DMA's role in antigen presentation is relevant to vaccine development, as it impacts the immune response generated by vaccines and influences the effectiveness of vaccination strategies.

In transplantation, how does HLA-DMA impact graft acceptance or rejection?

Understanding HLA-DMA's role is crucial in transplantation, as it affects the presentation of antigens from the graft, influencing the immune response and the likelihood of graft acceptance or rejection.

How does HLA-DMA contribute to the adaptive immune response?

HLA-DMA facilitates the loading of antigenic peptides onto MHC class II molecules, a process essential for the activation of CD4+ T cells and the adaptive immune response.

How does HLA-DMA relate to autoimmune diseases?

Aberrant antigen presentation mediated by HLA-DMA has been implicated in autoimmune diseases, as it may lead to the presentation of self-antigens and the activation of autoreactive T cells.

Can HLA-DMA be used as a biomarker in disease diagnosis?

Abnormalities in HLA-DMA expression or function may serve as biomarkers in disease diagnosis, providing insights into the dysregulation of antigen presentation pathways.