Recombinant Rat Ctla4 Protein, His-tagged
Cat.No. : | Ctla4-1144R |
Product Overview : | Recombinant rat Ctla4 (NP_113862.1) (Met1-Asp161) was expressed with a polyhistidine tag at the C-terminus. |
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Source : | HEK293 |
Species : | Rat |
Tag : | His |
Predicted N Terminal : | Glu 36 |
Form : | Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol. |
Molecular Mass : | The recombinant rat Ctla4 consists 137 amino acids and predicts a molecular mass of 15.2 kDa. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Rattus norvegicus ] |
Official Symbol : | Ctla4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; soluble form; CD152 antigen; transmembrane form; Cd152; CTLA-4; sCTLA4; |
Gene ID : | 63835 |
mRNA Refseq : | NM_031674 |
Protein Refseq : | NP_113862 |
MIM : | |
UniProt ID : | |
Pathway : | Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Cell adhesion molecules (CAMs), organis |
Function : | protein binding; receptor activity; |
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◆ Lysates | ||
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
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◆ Assay kits | ||
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
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