Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 647 conjugated

Cat.No. : Ctla4-1144RAF647
Product Overview : Alexa Fluor 647 conjugated recombinant rat Ctla4 (NP_113862.1) (Met1-Asp161) was expressed with a polyhistidine tag at the C-terminus.
Availability November 12, 2024
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Source : HEK293
Species : Rat
Tag : His
Form : Lyophilized
Molecular Mass : The recombinant rat Ctla4 consists 137 amino acids and predicts a molecular mass of 15.2 kDa.
Protein length : 137
N-terminal Sequence Analysis : Glu 36
Endotoxin : < 1.0 EU/ μg of the protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 647 via amines
Excitation = 650 nm
Emission = 668 nm
Stability : Samples are stable for up to 12 months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 to-70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile PBS, pH 7.4, 5%-8% trehalose and mannitol.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Rattus norvegicus ]
Official Symbol : Ctla4
Synonyms : CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; soluble form; CD152 antigen; transmembrane form; Cd152; CTLA-4; sCTLA4;
Gene ID : 63835
mRNA Refseq : NM_031674
Protein Refseq : NP_113862

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
04/17/2019

    It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

    11/25/2018

      The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.

      01/28/2017

        the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.

        Q&As (5)

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        Are there ongoing clinical trials exploring CTLA-4 inhibitors in combination with other immunotherapies? 05/16/2020

        Yes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.

        How does the expression of CTLA-4 vary in different types of immune cells? 10/17/2019

        CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.

        In what ways can CTLA-4 be utilized in organ transplantation? 01/11/2017

        Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.

        How does CTLA-4 contribute to the maintenance of immune tolerance? 04/30/2016

        CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.

        How does CTLA-4 blockade differ from PD-1/PD-L1 blockade in cancer immunotherapy? 03/18/2016

        While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.

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