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Active Recombinant Rat Hmgb1 protein, LPS-Free

Cat.No. : Hmgb1-19R
Product Overview : Recombinant Rat Hmgb1 was expressed in E. coli.
  • Specification
  • Gene Information
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Source : E. coli
Species : Rat
Form : 50 mM HEPES-Na pH 7.9, 500 mM NaCl, 0.5 mM DTT.
Bio-activity : Measured by its ability to induce migration. Maximal activity in the cell migration assay is obtained at 1 nM, or 25 ng/ml.
Molecular Mass : Has a calculated molecular mass of approximately 24.8 kDa. It migrates at a position of approximately 30 kD in SDS-PAGE gels, possibly because of the unusual number of positively charged amino acids it contains.
Protein length : HMGB1 consists of 215 amino acid residues.
AA Sequence : MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEDD EEDEEDEEEE EEEEDEDEEE DDDDE
Endotoxin : <0.4 ng LPS per mg protein
Purity : The purified protein is >95% homogeneous (electrophoresis and mass spectrometry). It contains no nucleic acids, nor IL-1beta.
Storage : Once resuspended can be stored frozen at -20 centigrade. To avoid cysteine oxidation, DTT 0.5mM is added during protein purification.
Gene Name : Hmgb1 high mobility group box 1 [ Rattus norvegicus ]
Official Symbol : Hmgb1
Synonyms : HMGB1; high mobility group box 1; high mobility group protein B1; HMG-1; amphoterin; high mobility group 1; heparin-binding protein p30; high mobility group protein 1; Hmg1; Ac2-008; MGC93598; MGC93599;
Gene ID : 25459
mRNA Refseq : NM_012963
Protein Refseq : NP_037095
UniProt ID : P63159
Chromosome Location : 12p11
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;
Function : 5S rRNA binding; DNA binding, bending; DNA binding, bending; RAGE receptor binding; RAGE receptor binding; bent DNA binding; calcium-dependent protein kinase regulator activity; crossed form four-way junction DNA binding; cytokine activity; cytokine activity; double-stranded DNA binding; four-way junction DNA binding; glycolipid binding; heparin binding; heparin binding; open form four-way junction DNA binding; peptide binding; protein binding; protein dimerization activity; protein kinase activator activity; repressing transcription factor binding; sequence-specific DNA binding transcription factor activity; single-stranded DNA binding; transcription factor binding; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Why is HMGB1 protein associated with tumors? 11/07/2019

This protein can promote tumor growth, invasion and angiogenesis, and plays an important role in tumor immune evasion.

Is HMGB1 protein involved in tumor metastasis? 11/05/2019

Yes, HMGB1 protein plays an important role in tumor metastasis, particularly by promoting invasion of tumor cells and migration of the hematopoietic system.

What is the association between HMGB1 protein and cardiovascular disease? 10/02/2019

Is involved in inflammatory response, vascular damage, and thrombosis in cardiovascular disease and may be associated with myocardial ischemia-reperfusion injury.

What is the effect of HMGB1 protein on the immune system? 08/31/2019

HMGB1 protein can promote the activation, chemotaxis and inflammatory response of immune cells, and is also involved in regulating the balance of autoimmune response.

What role does HMGB1 play in diabetes? 08/21/2019

HMGB1 protein is associated with processes such as chronic inflammation and insulin resistance in diabetes and may be a potential target for treatment and prevention.

Does HMGB1 play a role in liver disease? 08/15/2019

The protein is involved in pathological processes such as liver fibrosis, hepatitis, and liver cancer in liver disease and may be a target for therapeutic strategies.

Customer Reviews (3)

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Reviews
09/22/2021

    Broad storage conditions of HMGB1ins make the experimental process more stable and reliable, which provides a strong guarantee for scientific research.

    05/02/2020

      I found that tHMGB1 exhibited very good stability during storage, which allowed us to perform experiments easily and obtain reliable results.

      01/11/2019

        The anti-contamination ability of HMGB1 was excellent in Western blot, and the contamination problem in the experiment was avoided.

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