Recombinant Rat Pdcd1 Protein, hFc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | Pdcd1-560RAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant Rat Pdcd1 (Leu25-Gln167) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
Availability | December 09, 2024 |
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Description : | Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. |
Source : | HEK293 |
Species : | Rat |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 42.9 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | Leu25-Gln167 |
N-terminal Sequence Analysis : | Leu 25 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | Pdcd1 |
Official Symbol : | Pdcd1 |
Synonyms : | PDCD1; programmed cell death 1; programmed cell death protein 1 |
Gene ID : | 301626 |
mRNA Refseq : | NM_001106927 |
Protein Refseq : | NP_001100397 |
UniProt ID : | D3ZIN8 |
Products Types
◆ Recombinant Protein | ||
PDCD1-1033R | Active Recombinant Rat PDCD1 protein(Met1-Gln167), hFc-tagged | +Inquiry |
PDCD1-694H | Recombinant Human PDCD1 Protein | +Inquiry |
PDCD1-384H | Recombinant Human PDCD1 Protein (Met1-Gln167), His-Fc-tagged, Biotinylated | +Inquiry |
PDCD1-1490C | Recombinant Cynomolgus PDCD1 protein, His-tagged | +Inquiry |
PDCD1-702R | Recombinant Rabbit PDCD1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
PDCD1-2873HCL | Recombinant Human PDCD1 cell lysate | +Inquiry |
PDCD1-2628MCL | Recombinant Mouse PDCD1 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewTimely antibody validation, a valuable asset for our laboratory.
Precise protein quantification, fundamental for maintaining data accuracy.
Dependable peptide synthesis, accelerates our peptide-based projects effectively.
Q&As (14)
Ask a questionPDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.
PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.
PDCD1 helps develop immune tolerance, preventing overactive immune responses.
PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.
PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.
PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.
PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.
PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.
PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.
PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.
PDCD1 helps develop immune tolerance, preventing overactive immune responses.
Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.
PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.
Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.
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