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Recombinant Rhesus IL2RB Protein, Fc-tagged

Cat.No.: IL2RB-454R
Product Overview: Recombinant Rhesus IL2RB (NP_001244989.1) (Met1-Asp239) was expressed with the Fc region of human IgG1 at the C-terminus.
Description: Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated end centigradeytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymph centigradeytes, activated B lymph centigradeytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymph centigradeyte development.
Source: HEK293
Species: Rhesus
Tag : Fc
Predicted N Terminal: Ala 27
Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass: The recombinant rhesus IL2RB consists of 451 amino acids and predicts a molecular mass of 51.4 kDa.
Protein length: Met1-Asp239
Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
Purity: > 90 % as determined by SDS-PAGE.
Storage: Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Official Symbol: IL2RB
Synonyms: IL2RB;interleukin 2 receptor subunit beta;interleukin-2 receptor subunit beta;IL 2/15 receptor beta chain;interleukin 2 receptor, beta

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