| Cat. No. : |
IL13-146R |
| Description : |
Interleukin 13 (IL-13) is a single-chain cytokine which belongs to the IL13/IL4 family. In humans, IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL13 inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. Meanwhile, IL-13 synergizes with IL2 in regulating IFN-gamma synthesis. IL-13 binds to a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL13 Rα1 and IL13 Rα2), and exerts its effects through signal transducer and activator of transcription 6 (STAT6), like IL-4. Accordingly, IL-13 may be critical in regulating inflammatory and immune responses as a central mediator in various cell types. |
| Molecular Mass : |
The recombinant rhesus IL13 consists of 112 amino acids and has a calculated molecular mass of 12 kDa also estimated by SDS-PAGE under reducing conditions. |
| Source : |
CHO Cells. |
| Predicted N Terminal : |
Ser 21. |
| Endotoxin : |
< 1.0 EU per 1μg cytokine as determined by the LAL method. |
| Formulation : |
Supplied as a 0.2μm filtered solution of 20 mM Tris, 10 mM NaCl, pH 8.0. |
| Reconstitution : |
Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
| Purity : |
> 97%, as determined by SDS-PAGE. |
| Stability : |
Samples are stable for up to twelve months from date of receipt -70°C. |
| Storage : |
Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles. |
