Recombinant Human IL13, His-tagged

Cat.No. : IL13-14149H
Product Overview : Recombinant Human IL13 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Availability December 01, 2024
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Description : This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Source : E.coli
Species : Human
Tag : His
Protein length : 21-146a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : IL13 interleukin 13 [ Homo sapiens ]
Official Symbol : IL13
Synonyms : IL13; interleukin 13; interleukin-13; allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; MGC116786; MGC116788; MGC116789; P600; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13;
Gene ID : 3596
mRNA Refseq : NM_002188
Protein Refseq : NP_002179
MIM : 147683
UniProt ID : P35225
Chromosome Location : 5q31
Pathway : Asthma, organism-specific biosystem; Asthma, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem;
Function : cytokine activity; interleukin-13 receptor binding; protein binding;

Not For Human Consumption!

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11/29/2021

    Effective in Th2 cell differentiation.

    04/22/2020

      Good for cytokine assays.

      01/26/2019

        High yield in expression.

        Q&As (10)

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        How does flow cytometry help quantify IL13 receptor expression on different cell populations? 12/29/2022

        Flow cytometry quantifies IL13 receptor expression on cells.

        What are the benefits of using transgenic animal models to study IL13's in vivo functions? 07/05/2022

        Transgenic models illuminate IL13's in vivo functions.

        Could you explain the role of ELISA in quantifying IL13 secretion levels in cell cultures? 02/23/2022

        ELISA quantifies IL13 secretion in cell cultures accurately.

        How can siRNA knockdown experiments reveal IL13's effects on specific cellular processes? 06/13/2021

        siRNA knockdown uncovers IL13's specific cellular effects.

        How does co-immunoprecipitation identify interacting partners in IL13-mediated signaling complexes? 07/28/2019

        Co-immunoprecipitation identifies IL13 signaling partners.

        What techniques can differentiate IL13-mediated signaling pathways from IL4 pathways? 07/23/2019

        Differential techniques distinguish IL13 and IL4 signaling pathways.

        Could you elaborate on the use of reporter gene assays to assess IL13-driven transcriptional activity? 12/16/2018

        Reporter gene assays gauge IL13-driven transcription.

        Can you describe the applications of microarray analysis in profiling IL13-induced gene expression changes? 11/14/2018

        Microarray analysis profiles IL13-induced gene expression.

        What experimental methods determine the impact of IL13 on tissue remodeling processes? 08/04/2018

        Experimental methods reveal IL13's impact on tissue remodeling.

        How does site-directed mutagenesis help identify critical residues in IL13 receptor binding? 07/04/2018

        Site-directed mutagenesis identifies key residues in IL13 receptor binding.

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