| Description : |
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Source : |
HEK293 |
| Species : |
Rhesus macaque |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
45.9 kDa |
| Protein Length : |
278 |
| AA Sequence : |
MVRLPLQCVLWGCLLTAVYPEPPTA CREKQYLINSQCCSLCQPGQKLVSD CTEFTETECLPCSESEFLDTWNRET RCHQHKYCDPNLGLRVQQKGTSETD TICTCEEGLHCMSESCESCVPHRSC LPGFGVKQIATGVSDTICEPCPVGF FSNVSSAFEKCRPWTSCETKDLVVQ QAGTNKTDVVCGPQDRQRALVVIPI CLGILFVILLLVLVFIKKVAKKPND KAPHPKQEPQEINFLDDLPGSNPAA PVQETLHGCQPVTQEDGKESRISVQ ERQ |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
