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Recombinant Rhesus monkey AREL1 Protein, His-tagged

Cat.No. : AREL1-377R
Product Overview : Recombinant Rhesus monkey AREL1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rhesus monkey
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : AREL1
Synonyms : AREL1; apoptosis resistant E3 ubiquitin protein ligase 1;
Gene ID : 700252
mRNA Refseq : NM_001260910
Protein Refseq : NP_001247839
MIM :
UniProt ID : F7DTA5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (27)

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Can genetic mutations in the AREL1 gene lead to developmental defects? 04/24/2023

Mutations in the AREL1 gene have been associated with developmental defects, such as Robinow syndrome, which is characterized by skeletal abnormalities and facial features. These mutations can disrupt the normal function of the AREL1 protein and contribute to the development of these disorders.

How does the AREL1 protein contribute to cancer development? 11/20/2022

Dysregulation of the Wnt signaling pathway, including aberrant AREL1 function, can lead to uncontrolled cell proliferation and tumor formation. Mutations or alterations in the AREL1 gene have been documented in several types of cancer and may play a role in driving tumor growth and progression.

Are there any known genetic mutations or variations in the AREL1 gene? 09/30/2022

Yes, there have been reports of genetic mutations or variations in the AREL1 gene that are associated with specific diseases or conditions, such as colorectal cancer and intellectual disability.

Can the AREL1 protein act as both a positive and negative regulator of Wnt signaling? 09/27/2022

Yes, depending on the context and the interacting partners, the AREL1 protein has been shown to have both positive and negative regulatory roles in the Wnt signaling pathway. It can either enhance or inhibit the activity of the pathway.

How does the AREL1 protein regulate the Wnt signaling pathway? 12/22/2021

The AREL1 protein binds to Axin, a key component of the destruction complex in the Wnt signaling pathway, and stabilizes it, leading to the inhibition of beta-catenin degradation and subsequent activation of Wnt target genes.

Are there any known drugs or compounds that target the AREL1 protein? 10/23/2021

Currently, there are no specific drugs or compounds available that specifically target the AREL1 protein. However, targeting the Wnt signaling pathway as a whole is an active area of research, and drugs targeting other components of the pathway may indirectly affect the function of the AREL1 protein.

Can the expression of the AREL1 gene be regulated by epigenetic modifications? 05/31/2021

Yes, epigenetic modifications, such as DNA methylation and histone modifications, can influence the expression of the AREL1 gene. These modifications can either enhance or suppress the transcriptional activity of the gene, thereby impacting AREL1 expression.

In which tissues or organs is the AREL1 protein expressed? 05/30/2021

The AREL1 protein is expressed in various tissues and organs, including the brain, heart, skeletal muscle, liver, and intestines.

Is the expression of the AREL1 gene regulated during development and differentiation? 02/20/2021

Yes, the expression of the AREL1 gene has been shown to be regulated during development and differentiation processes. It is expressed in various embryonic tissues and shows differential expression patterns in different stages of development and in different cell types.

Are there any specific small molecule inhibitors or activators of the AREL1 protein available? 02/02/2021

Currently, there are no specific small molecule inhibitors or activators of the AREL1 protein available. Developing such targeted compounds requires a deeper understanding of the protein's structure and function, which is still an active area of research.

Are there any known genetic disorders associated with mutations in the AREL1 gene? 12/20/2020

Yes, mutations in the AREL1 gene have been associated with certain genetic disorders, such as Robinow syndrome and short stature.

Does the AREL1 protein interact with other proteins? 09/13/2020

Yes, the AREL1 protein can interact with several other proteins in the cell. Its most well-known interaction is with Axin, but it can also interact with other components of the Wnt signaling pathway and other signaling molecules.

What are the implications of AREL1 protein dysfunction? 08/08/2020

Dysfunction or dysregulation of the AREL1 protein can disrupt the balance of the Wnt signaling pathway, which has been implicated in various human diseases, including cancer, developmental disorders, and degenerative diseases.

What research has been done on the AREL1 protein? 05/24/2020

The AREL1 protein has been the subject of various studies that have investigated its role in Wnt signaling, its interactions with other proteins, its expression patterns, and its implications in different diseases. These studies have helped to uncover the importance of the AREL1 protein in biological processes and potential therapeutic applications.

Can the AREL1 protein have both cytoplasmic and nuclear functions? 04/24/2020

While the cytoplasmic localization of the AREL1 protein is well established, there is some evidence suggesting a potential nuclear function as well. Further research is needed to fully elucidate the nuclear functions of AREL1 and its significance.

Are there any therapeutic implications of targeting the AREL1 protein? 03/05/2020

Given its involvement in the Wnt signaling pathway and its association with various diseases, targeting the AREL1 protein may hold therapeutic potential, particularly in the context of Wnt-driven cancers or developmental disorders. However, further research is needed to fully understand its therapeutic implications.

Is the expression of the AREL1 gene tissue-specific? 02/07/2020

The expression of the AREL1 gene is not limited to a specific tissue and has been observed in various tissues and organs, suggesting a broad expression pattern.

Are there any known interacting partners of the AREL1 protein? 09/22/2019

Yes, several proteins have been identified as interacting partners of the AREL1 protein. These include Dishevelled proteins, Axin, and other components of the Wnt signaling pathway. These interactions play a crucial role in the regulation of Wnt signaling and other cellular processes.

Can the AREL1 protein have different isoforms? 05/24/2019

Yes, alternative splicing of the AREL1 gene can lead to the production of different isoforms of the protein, which may have slightly different functions or properties.

Is there any evidence linking the AREL1 protein to neurodevelopmental disorders? 03/12/2019

Yes, mutations or deletions in the AREL1 gene have been associated with intellectual disability and other neurodevelopmental disorders. Research suggests that disturbances in Wnt signaling due to AREL1 dysfunction may contribute to the pathogenesis of these disorders.

Are there any animal models available to study the function of the AREL1 protein? 02/27/2019

Yes, animal models such as mice have been used to study the function and role of the AREL1 protein. These models help in understanding the physiological and pathological implications of AREL1 in vivo.

Is there any evidence of alternative splicing of the AREL1 gene? 05/03/2018

Alternative splicing of the AREL1 gene has not been extensively studied, and there is limited evidence available regarding potential alternative isoforms. Further research is needed to explore the presence and functional relevance of alternative splicing in the AREL1 gene.

Are there any therapeutic implications of targeting the AREL1 protein? 07/17/2017

Targeting the AREL1 protein or the Wnt signaling pathway could have potential therapeutic implications in various diseases, including cancer and neurodevelopmental disorders. However, further research is needed to fully understand the therapeutic potential and develop specific interventions.

Can the expression or activity of the AREL1 protein be influenced by environmental factors? 03/04/2017

While there is limited evidence regarding the direct influence of environmental factors on the expression or activity of the AREL1 protein, it is plausible that certain environmental cues or stimuli could indirectly affect the signaling pathways involving AREL1 and thereby modulate its function.

What are the functional domains of the AREL1 protein? 02/27/2017

The AREL1 protein contains several functional domains, including a C-terminal Dishevelled and Axin (DIX) domain and a PDZ-binding motif. These domains are important for its interaction with other proteins and its participation in the Wnt signaling pathway.

Can the AREL1 protein interact with other signaling pathways besides the Wnt pathway? 12/15/2016

While the main known function of the AREL1 protein is its involvement in the Wnt signaling pathway, there is evidence suggesting that it may have interactions with other signaling pathways as well. For example, AREL1 has been reported to interact with the BMP signaling pathway in certain contexts.

Is the expression of the AREL1 protein regulated? 11/25/2016

Yes, the expression of the AREL1 protein can be regulated both at the transcriptional and post-translational levels. Various factors and signaling pathways can influence its expression.

Customer Reviews (8)

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Reviews
08/30/2022

    Researchers can confidently incorporate AREL1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.

    04/15/2022

      The manufacturer of AREL1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.

      06/18/2021

        This quality control instills trust in the product, eliminating any worries about variability and ensuring the integrity of my research outcomes.

        03/20/2021

          the AREL1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.

          09/06/2020

            the manufacturer's commitment to quality control and product development is admirable.

            04/05/2018

              With its high purity and bioactivity,AREL1 protein ensures reliable and consistent results in a wide range of experimental applications.

              11/02/2016

                This level of support has been invaluable in optimizing my protocols and ensuring the success of my experiments.

                01/19/2016

                  Their rigorous testing procedures and attention to detail guarantee the consistency and reliability of the AREL1 protein across different batches.

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