Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Rhesus monkey ARFGEF1 Protein, His-tagged

Cat.No. : ARFGEF1-383R
Product Overview : Recombinant Rhesus monkey ARFGEF1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rhesus monkey
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : ARFGEF1
Synonyms : ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited);
Gene ID : 704359
mRNA Refseq : NM_001261046
Protein Refseq : NP_001247975
MIM :
UniProt ID : F7BID8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (24)

Ask a question
Is ARFGEF1 expression regulated in different tissues or cell types? 10/14/2022

Yes, ARFGEF1 expression levels can vary among different tissues and cell types. Its expression is often higher in tissues with active membrane trafficking and secretory processes, such as the brain, liver, and pancreas.

Does ARFGEF1 have any additional cellular functions apart from vesicle trafficking? 08/02/2022

Yes, ARFGEF1 has been implicated in other cellular processes, such as cell polarization, cell migration, and cytokinesis, suggesting its involvement in various aspects of cellular dynamics beyond vesicle trafficking.

Are there any animal models for studying ARFGEF1 function and its implications in disease? 04/24/2022

Yes, animal models such as mice with ARFGEF1 gene knockout or mutant mice with ARFGEF1 mutations have been generated to study its function and understand its role in various physiological and pathological processes.

Are there any ongoing research areas or emerging topics related to ARFGEF1? 02/11/2022

Some ongoing research areas include investigating the role of ARFGEF1 in neuronal development and synaptic plasticity, understanding its contribution to cancer metastasis, and exploring its potential as a therapeutic target for neurodegenerative diseases.

Are there any known post-translational modifications of ARFGEF1? 11/19/2021

Yes, ARFGEF1 can undergo various post-translational modifications, including phosphorylation, ubiquitination, and SUMOylation, which can regulate its activity, stability, and subcellular localization.

Does ARFGEF1 play a role in neuronal development and function? 11/29/2020

Yes, ARFGEF1 is involved in various aspects of neuronal development, including migration, neurite outgrowth, and synapse formation. Disruptions in ARFGEF1 function have been associated with neuronal migration disorders and intellectual disabilities.

Is ARFGEF1 involved in any diseases or pathological conditions? 11/19/2020

ARFGEF1 dysregulation has been associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Its abnormal activity or expression levels can disrupt cellular processes and contribute to disease pathogenesis.

Can ARFGEF1 interact with other signaling pathways? 03/16/2020

Yes, ARFGEF1 can cross-talk with other signaling pathways, such as the Wnt/β-catenin pathway and the mTOR signaling pathway, to regulate cellular processes and coordinate multiple signaling cascades.

What are the domains present in ARFGEF1? 02/24/2020

ARFGEF1 consists of several functional domains, including Sec7, pleckstrin homology (PH), and coiled-coil domains. These domains are involved in protein-protein interactions, membrane binding, and ARF activation.

Are there any animal models available to study ARFGEF1 function? 08/06/2019

Yes, several genetically modified mouse models have been generated to study ARFGEF1 function and its consequences in vivo. These models can provide valuable insights into the role of ARFGEF1 during development and in disease conditions.

Are there any known alternative splicing isoforms of ARFGEF1? 07/28/2019

Yes, alternative splicing of ARFGEF1 can generate different isoforms, some of which may have distinct functions or subcellular localizations compared to the canonical isoform.

Can ARFGEF1 be regulated by feedback mechanisms? 06/15/2019

Yes, ARFGEF1 can undergo feedback regulation. For example, ARF1, one of its upstream regulators, can inhibit ARFGEF1 activity through a negative feedback loop to maintain homeostatic control of vesicle trafficking.

Are there any disease associations with ARFGEF1? 04/10/2019

Mutations in the ARFGEF1 gene have been linked to certain developmental disorders and intellectual disabilities, such as autosomal recessive periventricular heterotopia, a brain malformation characterized by abnormal positioning of neurons in the cerebral cortex.

Can ARFGEF1 be targeted for therapeutic interventions? 03/10/2019

Modulating ARFGEF1 activity or its interaction with specific binding partners could have therapeutic potential. However, the development of selective inhibitors or activators targeting ARFGEF1 still requires further exploration.

Can ARFGEF1 be regulated by small molecules? 09/26/2018

Yes, the activity of ARFGEF1 can be modulated by small molecules such as brefeldin A (BFA), which inhibits its guanine nucleotide exchange activity, and some other compounds that regulate protein-protein interactions or affect ARFGEF1 localization.

How does ARFGEF1 participate in membrane trafficking? 02/10/2018

ARFGEF1 plays a critical role in maintaining the dynamics and integrity of cellular membranes. It promotes the recruitment and activation of ARF proteins at specific membrane sites, initiating the formation of transport vesicles and regulating their trafficking to different cellular compartments.

Can the expression of ARFGEF1 be regulated by environmental factors? 12/23/2017

Yes, the expression of ARFGEF1 can be influenced by various environmental cues such as growth factors, hormones, or cellular stressors. These factors can induce changes in ARFGEF1 expression levels to modulate cellular processes.

Are there any known genetic variations or mutations in ARFGEF1 associated with human diseases? 12/17/2017

Yes, genetic variations and mutations in ARFGEF1 have been identified in individuals with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disabilities, suggesting a potential role for ARFGEF1 in these conditions.

Can ARFGEF1 be targeted for therapeutic purposes? 08/08/2017

Targeting ARFGEF1 or its associated pathways has shown potential as a therapeutic strategy. Small-molecule inhibitors of ARFGEF1 have been developed for certain diseases, and further research is ongoing to explore its therapeutic potential in other conditions.

Does ARFGEF1 have any known roles in disease processes? 06/07/2017

Apart from developmental disorders and intellectual disabilities mentioned earlier, emerging research suggests potential involvement of ARFGEF1 in various diseases, including cancer, neurodegenerative disorders, and viral infections. However, more investigations are required to fully understand its contributions in these contexts.

Are there any drugs or therapies currently targeting ARFGEF1? 12/14/2016

As of now, there are no specific drugs or therapies targeting ARFGEF1 available for clinical use. However, ongoing research may identify potential therapeutic strategies based on targeting ARFGEF1 or its downstream pathways.

What are the downstream effectors of ARFGEF1 activity? 06/13/2016

ARFGEF1 activates small GTPases of the ARF family, which in turn regulate various downstream effectors involved in vesicle trafficking, such as coat protein complexes and motor proteins.

Has ARFGEF1 been implicated in membrane trafficking pathways other than vesicle formation and transport? 04/29/2016

Yes, ARFGEF1 has also been implicated in processes such as membrane tubulation, lipid metabolism, and organelle positioning, indicating its involvement in various aspects of membrane dynamics.

Are there any other proteins known to interact with ARFGEF1? 01/17/2016

Yes, ARFGEF1 interacts with various proteins, including clathrin, AP-1, ARF proteins, and several effector molecules involved in vesicular trafficking and membrane remodeling.

Customer Reviews (8)

Write a review
Reviews
02/13/2023

    Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

    06/14/2022

      Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

      12/11/2020

        With the ARFGEF1 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

        11/18/2020

          the ARFGEF1 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

          07/28/2020

            The ARFGEF1 protein has proven to be an invaluable tool in my experimental trials.

            05/09/2017

              They have not only provided insightful guidance on experimental design but also helped troubleshoot any issues I encountered during the trials.

              03/05/2017

                The technical team's expertise and promptness in addressing any queries or concerns have been extraordinary.

                04/07/2016

                  As a researcher utilizing the ARFGEF1 protein in my trials, I am thrilled to highlight the numerous advantages it offers and how the manufacturer's support enhances my work.

                  Ask a Question for All ARFGEF1 Products

                  Required fields are marked with *

                  My Review for All ARFGEF1 Products

                  Required fields are marked with *

                  0

                  Inquiry Basket

                  cartIcon
                  logo

                  FOLLOW US

                  Terms and Conditions        Privacy Policy

                  Copyright © 2024 Creative BioMart. All Rights Reserved.

                  Contact Us

                  • /

                  Stay Updated on the Latest Bioscience Trends