Recombinant Rhesus monkey ARFGEF1 Protein, His-tagged
Cat.No. : | ARFGEF1-383R |
Product Overview : | Recombinant Rhesus monkey ARFGEF1 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Rhesus monkey |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | ARFGEF1 |
Synonyms : | ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); |
Gene ID : | 704359 |
mRNA Refseq : | NM_001261046 |
Protein Refseq : | NP_001247975 |
MIM : | |
UniProt ID : | F7BID8 |
Products Types
◆ Recombinant Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (24)
Ask a questionYes, ARFGEF1 expression levels can vary among different tissues and cell types. Its expression is often higher in tissues with active membrane trafficking and secretory processes, such as the brain, liver, and pancreas.
Yes, ARFGEF1 has been implicated in other cellular processes, such as cell polarization, cell migration, and cytokinesis, suggesting its involvement in various aspects of cellular dynamics beyond vesicle trafficking.
Yes, animal models such as mice with ARFGEF1 gene knockout or mutant mice with ARFGEF1 mutations have been generated to study its function and understand its role in various physiological and pathological processes.
Some ongoing research areas include investigating the role of ARFGEF1 in neuronal development and synaptic plasticity, understanding its contribution to cancer metastasis, and exploring its potential as a therapeutic target for neurodegenerative diseases.
Yes, ARFGEF1 can undergo various post-translational modifications, including phosphorylation, ubiquitination, and SUMOylation, which can regulate its activity, stability, and subcellular localization.
Yes, ARFGEF1 is involved in various aspects of neuronal development, including migration, neurite outgrowth, and synapse formation. Disruptions in ARFGEF1 function have been associated with neuronal migration disorders and intellectual disabilities.
ARFGEF1 dysregulation has been associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Its abnormal activity or expression levels can disrupt cellular processes and contribute to disease pathogenesis.
Yes, ARFGEF1 can cross-talk with other signaling pathways, such as the Wnt/β-catenin pathway and the mTOR signaling pathway, to regulate cellular processes and coordinate multiple signaling cascades.
ARFGEF1 consists of several functional domains, including Sec7, pleckstrin homology (PH), and coiled-coil domains. These domains are involved in protein-protein interactions, membrane binding, and ARF activation.
Yes, several genetically modified mouse models have been generated to study ARFGEF1 function and its consequences in vivo. These models can provide valuable insights into the role of ARFGEF1 during development and in disease conditions.
Yes, alternative splicing of ARFGEF1 can generate different isoforms, some of which may have distinct functions or subcellular localizations compared to the canonical isoform.
Yes, ARFGEF1 can undergo feedback regulation. For example, ARF1, one of its upstream regulators, can inhibit ARFGEF1 activity through a negative feedback loop to maintain homeostatic control of vesicle trafficking.
Mutations in the ARFGEF1 gene have been linked to certain developmental disorders and intellectual disabilities, such as autosomal recessive periventricular heterotopia, a brain malformation characterized by abnormal positioning of neurons in the cerebral cortex.
Modulating ARFGEF1 activity or its interaction with specific binding partners could have therapeutic potential. However, the development of selective inhibitors or activators targeting ARFGEF1 still requires further exploration.
Yes, the activity of ARFGEF1 can be modulated by small molecules such as brefeldin A (BFA), which inhibits its guanine nucleotide exchange activity, and some other compounds that regulate protein-protein interactions or affect ARFGEF1 localization.
ARFGEF1 plays a critical role in maintaining the dynamics and integrity of cellular membranes. It promotes the recruitment and activation of ARF proteins at specific membrane sites, initiating the formation of transport vesicles and regulating their trafficking to different cellular compartments.
Yes, the expression of ARFGEF1 can be influenced by various environmental cues such as growth factors, hormones, or cellular stressors. These factors can induce changes in ARFGEF1 expression levels to modulate cellular processes.
Yes, genetic variations and mutations in ARFGEF1 have been identified in individuals with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disabilities, suggesting a potential role for ARFGEF1 in these conditions.
Targeting ARFGEF1 or its associated pathways has shown potential as a therapeutic strategy. Small-molecule inhibitors of ARFGEF1 have been developed for certain diseases, and further research is ongoing to explore its therapeutic potential in other conditions.
Apart from developmental disorders and intellectual disabilities mentioned earlier, emerging research suggests potential involvement of ARFGEF1 in various diseases, including cancer, neurodegenerative disorders, and viral infections. However, more investigations are required to fully understand its contributions in these contexts.
As of now, there are no specific drugs or therapies targeting ARFGEF1 available for clinical use. However, ongoing research may identify potential therapeutic strategies based on targeting ARFGEF1 or its downstream pathways.
ARFGEF1 activates small GTPases of the ARF family, which in turn regulate various downstream effectors involved in vesicle trafficking, such as coat protein complexes and motor proteins.
Yes, ARFGEF1 has also been implicated in processes such as membrane tubulation, lipid metabolism, and organelle positioning, indicating its involvement in various aspects of membrane dynamics.
Yes, ARFGEF1 interacts with various proteins, including clathrin, AP-1, ARF proteins, and several effector molecules involved in vesicular trafficking and membrane remodeling.
Customer Reviews (8)
Write a reviewIts versatility and reliability make it a great asset in the pursuit of scientific discoveries.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
With the ARFGEF1 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.
the ARFGEF1 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.
The ARFGEF1 protein has proven to be an invaluable tool in my experimental trials.
They have not only provided insightful guidance on experimental design but also helped troubleshoot any issues I encountered during the trials.
The technical team's expertise and promptness in addressing any queries or concerns have been extraordinary.
As a researcher utilizing the ARFGEF1 protein in my trials, I am thrilled to highlight the numerous advantages it offers and how the manufacturer's support enhances my work.
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