Recombinant Rhesus monkey EXT1 Protein, His-tagged

• Cat.No.: EXT1-1524R
• Product Overview: Recombinant Rhesus monkey EXT1 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Rhesus monkey
• Tag: His
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: EXT1 exostosin 1 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: EXT1
• Synonyms: EXT1; exostosin 1; Exostosin-1; exostoses (multiple) 1
• Gene ID: 701488
• mRNA Refseq: NM_001258133
• Protein Refseq: NP_001245062
• UniProt ID: F7F8Y3

Reviews

05/04/2020

Product delivered on time.

03/08/2020

Highly recommend this product.

04/06/2019

Very effective, good quality.

Q&As

Are there any known interacting proteins that influence EXT1 function?

EXT1 forms a complex with EXT2, another glycosyltransferase, for its stability and proper function.

What potential therapeutic strategies might target EXT1 or its pathways?

Therapeutic strategies might involve targeted therapies to correct heparan sulfate chain synthesis or modulate affected signaling pathways.

Which tissues or cell types show predominant expression of EXT1?

EXT1 is ubiquitously expressed but shows higher expression in certain tissues such as cartilage.

How does the mutation of EXT1 impact heparan sulfate biosynthesis?

Mutations in EXT1 result in shortened heparan sulfate chains, affecting their function and interaction with signaling molecules.

How does the dysregulation of EXT1 impact cellular signaling pathways?

Dysregulation of EXT1 affects pathways such as Hedgehog, Wnt, and FGF signaling, leading to abnormal growth and development.

What is the primary role of the EXT1 enzyme in cellular processes?

EXT1 is involved in the elongation of heparan sulfate chains, a critical component for cell signaling, adhesion, and growth.

What genetic conditions are associated with mutations in EXT1?

Mutations in EXT1 are associated with hereditary multiple exostoses (HME), a condition characterized by the formation of bony outgrowths.