Recombinant Staphylococcus aureus (strain: TPS162) ARSC protein, His-tagged

• Cat.No.: ARSC-1835S
• Product Overview: Recombinant Staphylococcus aureus (strain: TPS162) ARSC full length or partial length protein was expressed.

Specification

• Source: E. coli or Yeast
• Species: Staphylococcus
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 80% by SDS-PAGE
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage buffer: PBS buffer

Gene Information

• Gene Name: arsC arsenate reductase [ Staphylococcus aureus ]
• Official Symbol: ARSC
• Synonyms: ARSC; arsenate reductase
• Gene ID: 6155824
• UniProt ID: P0A006

Reviews

02/01/2022

The unmatched performance of the ARSC protein in both ELISA assays and protein electron microscopy structure analysis showcases its versatility and reliability in various experimental settings.

12/16/2020

With its exceptional specificity and sensitivity, it enables precise and reliable detection of target molecules, making it a valuable tool in the field of diagnostic and research applications.

01/13/2016

Scientists can confidently rely on the ARSC protein's exceptional attributes to generate accurate and biologically relevant data for their research.

Q&As

How does ARSC contribute to the degradation of sulfatides?

ARSC acts as an arylsulfatase, catalyzing the hydrolysis of sulfate groups from sulfatides. This cleavage of sulfate groups allows for further degradation of sulfatides by other enzymes.

How can ARSC deficiency be diagnosed?

ARSC deficiency can be diagnosed through genetic testing to identify mutations in the ARSC gene. Additionally, biochemical tests can be performed to assess the activity levels of the ARSC enzyme in various tissues or cells.

Are there any treatments available for disorders caused by ARSC deficiency?

Currently, there are no specific treatment options available for disorders caused by ARSC deficiency. However, supportive care and symptom management can be provided to individuals with these conditions.

Can mutations in the ARSC gene cause any specific diseases?

Yes, mutations in the ARSC gene can result in metachromatic leukodystrophy-like disorder (MLDLD). MLDLD is a rare genetic disorder characterized by the accumulation of sulfatides due to ARSC deficiency.

Is there ongoing research on the ARSC enzyme and related disorders?

Yes, researchers continue to study the function and role of the ARSC enzyme in lysosomal storage disorders. They are exploring potential therapeutic strategies, such as enzyme replacement therapy and gene therapy, to address these disorders in the future.

What happens if there is a deficiency of the ARSC enzyme?

A deficiency of the ARSC enzyme leads to the accumulation of sulfatides within lysosomes. This buildup can result in various lysosomal storage disorders, such as metachromatic leukodystrophy.

How is the ARSC enzyme targeted to lysosomes?

The ARSC enzyme contains a specific targeting signal, known as a mannose-6-phosphate (M6P) tag. This M6P tag helps the enzyme bind to M6P receptors in the Golgi apparatus, leading to its packaging into vesicles that ultimately fuse with lysosomes.

What other proteins or enzymes interact with ARSC in its function?

ARSC may interact with other lysosomal enzymes or transport proteins involved in the degradation and transport of sulfated carbohydrates. Some examples include arylsulfatase A (ARSA), glucosamine-6-sulfatase (GNS), and the mannose-6-phosphate receptor.

How is the ARSC protein synthesized within the cell?

The ARSC protein is synthesized in the endoplasmic reticulum (ER) as a precursor protein. It then undergoes post-translational modifications, including proper folding and glycosylation, before being transported to the Golgi apparatus for further processing.