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Recombinant Zebrafish IL22 Protein, His-tagged

Cat.No. : IL22-60Z
Product Overview : Recombinant Zebrafish IL22 Protein, fused to His-tag, was expressed in E. coli.
Availability February 10, 2025
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Description : Acts upstream of or within defense response to Gram-negative bacterium; immune response; and regulation of inflammatory response. Is expressed in several structures, including caudal fin; gill; heart; liver; and pleuroperitoneal region. Orthologous to human IL22 (interleukin 22).
Source : E. coli
Species : Zebrafish
Tag : His
Form : Supplied as a 0.2 μm filtered solution in PBS, 1 mM DTT (pH8.0).
Molecular Mass : ~25 kDa
AA Sequence : MHHHHHHMGDYAKGEKTTTVTYRHD IKAPEPQDALQVSTSRNNGVHKRTD TRIHSSTCDMKCFTLIALLCSCFLS GCARPTPLDSSATWNDLAAMTDTAR NEDDHETRLLPYFSHDMLQEEGSCC INARILKYYVNHVLESDEHTDMKYP MIRNVREGLHRVEQELQNHCKHDYS SHPLVKQFKRNYHASAIMDLAAARN KAIGETNTLYHYLFESCTPK
Purity : >90%
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.13 mg/ml
Gene Name : il22 interleukin 22 [ Danio rerio (zebrafish) ]
Official Symbol : IL22
Synonyms : TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
Gene ID : 553964
mRNA Refseq : NM_001020792
Protein Refseq : NP_001018628
UniProt ID : Q5TLE4

Not For Human Consumption!

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Customer Reviews (3)

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04/07/2021

    High specificity.

    03/29/2021

      Good for Th17 differentiation.

      07/07/2016

        Effective in gut repair assays.

        Q&As (10)

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        What is IL22's role in gut epithelial repair? 02/05/2022

        IL22 enhances gut epithelial repair mechanisms.

        What are the downstream targets of IL22 signaling? 12/27/2021

        IL22 activates STAT3 to modulate downstream targets.

        How does IL22 interact with other cytokines in inflammation? 10/06/2021

        IL22 interacts synergistically with IL-17 during inflammation.

        Is IL22 involved in the pathogenesis of autoimmune diseases? 06/25/2021

        IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

        Does IL22 have a role in metabolic syndrome? 02/23/2021

        IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

        How is IL22 expression regulated in psoriasis? 09/05/2018

        IL22 expression is upregulated in psoriasis.

        Does IL22 expression change during viral infections? 07/26/2018

        IL22 expression is upregulated during viral infections like Hepatitis C.

        Does IL22 contribute to anti-tumor immunity? 03/14/2018

        IL22 contributes to anti-tumor immunity by activating NK cells.

        How does IL22 modulate T-cell differentiation? 10/30/2017

        IL22 promotes Th22 cell differentiation.

        What impact do IL22 polymorphisms have on its function? 09/25/2017

        IL22 polymorphisms affect its binding affinity and signaling.

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