|Official Full Name||Chemokine (C-C motif) ligand 19|
|Background||Studies have shown that MIP-3B may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. In addition, this protein may play an important role in trafficking of T- cells in thymus, and T-cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. MIP-3B is expressed at high levels in the lymph nodes, thymus and appendix, intermediate levels in colon and trachea, and low levels in spleen, small intestine, lung, kidney and stomach. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7.|
|Synonyms||CCL19; RP11-195F19.11-003; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine 19; CC chemokine ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CCL19 involved in several pathways and played different roles in them. We selected most pathways CCL19 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||TNFRSF1B; CXCL8B.3; LTA; BMPR2; TNFRSF17; CRLF2; IFNG; CCL18; IFNG1-2; CXCR4A|
|Chemokine signaling pathway||PF4V1; MAPK3; ADRBK2; CXCR6; HRAS; PIK3CB; CXCL3; ARRB1; RAP1B; AMCF-II|
|NF-kappa B signaling pathway||ATM; PLCG1; TRAF1; TRADD; LCK; PRKCB; TLR4; XIAP; PLAU; PLCG2|
CCL19 has several biochemical functions, for example, CCR chemokine receptor binding, CCR10 chemokine receptor binding, CCR7 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL19 itself. We selected most functions CCL19 had, and list some proteins which have the same functions with CCL19. You can find most of the proteins on our site.
|CCR chemokine receptor binding||CCL38A.5; CCL11; CCL24; CCL25B; CCL13; CCL1; CCRL2; CCL14; CCL20B; CCL8|
|CCR10 chemokine receptor binding||CCL19; CCL25; CXCL13|
|CCR7 chemokine receptor binding||CCL19; CCL21|
|chemokine activity||CXCL9; CCL21; CXCL32B.1; CXCL10; CXCL16; CCL19; CCL25; CXL34B.11; CCL20; CCL27|
|chemokine receptor binding||CXCL12; Ccl21a; CCRL2; S100A14; Ccl21c; CCL25; CCL19; CCL5; CCL21B; XCL1|
CCL19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL19.