CCL19
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Official Full Name
Chemokine (C-C motif) ligand 19
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Overview
Studies have shown that MIP-3B may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. In addition, this protein may play an important role in trafficking of T- cells in thymus, and T-cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. MIP-3B is expressed at high levels in the lymph nodes, thymus and appendix, intermediate levels in colon and trachea, and low levels in spleen, small intestine, lung, kidney and stomach. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7. -
Synonyms
CCL19; RP11-195F19.11-003; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine 19; CC chemokine ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Cynomolgus Monkey
- Dog
- Horse
- Human
- Monkey
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- Swine
- CHO
- E.coli
- HEK293
- Human Cells
- In Vitro Cell Free System
- Insect Cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Biotin
- Fc
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- CCL19 Related Articles
- CCL19 Related Gene Family
- CCL19 Related Research Area
CCL19 involved in several pathways and played different roles in them. We selected most pathways CCL19 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | CXCL9;TNFRSF13C;IL11RA;CCL2;GM2506;PDGFC;CCR3;CSF2;Ifna11 |
Chemokine signaling pathway | PRKACA;PLCB3;PRKCZ;CXCR4;CCR1;CCL22;ARRB1;CCL3L1;NRAS |
NF-kappa B signaling pathway | TNFRSF11A;PTGS2;RIPK1;BIRC2;LCK;TRAF5;TNFSF14;TNFRSF1A;LTA |
CCL19 has several biochemical functions, for example, CCR chemokine receptor binding, CCR10 chemokine receptor binding, CCR7 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL19 itself. We selected most functions CCL19 had, and list some proteins which have the same functions with CCL19. You can find most of the proteins on our site.
Function | Related Protein |
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CCR chemokine receptor binding | CCL20;CCRL2;CCL19A.1;CCL19A.2;CCL35.1;CCL38A.4;CCL38A.5;CCL19B;CCL19 |
CCR10 chemokine receptor binding | CCL25;CXCL13;CCL19 |
CCR7 chemokine receptor binding | CCL21;CCL19 |
chemokine activity | CCL34A.4;CCL25B;CCL20;CCL16;CXCL11;CCL24;CXCL14;CCL3L1;CXCL12B |
chemokine receptor binding | XCL1;Ccl21c;CCL25;CCL21B;Ccl21a;S100A14;CCRL2;CCL21;CCL19 |
CCL19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL19.
- Q&As
- Reviews
Q&As (6)
Ask a questionThere are still some limitations in the current research on CCL19, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since CCL19 is a multifunctional protein, regulating it may also have some side effects.
It has a complex relationship with other chemokines or proteins. For example, it binds to the CCR7 receptor, which directs the migration of immune cells. In addition, CCL19 interacts with other chemokines and cytokines to jointly regulate immune responses.
Therapeutic strategies for CCL19 include inhibition of its expression, modulation of its activity, or use of gene therapy. For example, some studies have shown that the use of small molecule inhibitors or antibodies against CCL19 can inhibit its activity and thus treat some CCL19-related diseases. In addition, related diseases can also be treated by regulating the expression level of CCL19.
In order to better understand the role of CCL19 in disease, further in-depth study of its specific mechanism of action and function is needed. In addition, it is also necessary to study the changes in its expression level and activity in different diseases, as well as its relationship with the occurrence and development of diseases. At the same time, it is also necessary to explore the clinical application prospects and effects of the therapeutic strategies that regulate them. This will contribute to the development of more effective treatments to improve outcomes and quality of life for patients with CCL19-related diseases.
CCL19 is mainly involved in the recruitment and activation of immune cells. It is able to exert immune defense by binding to receptors on the cell surface to direct immune cells to migrate to the site of inflammation or infection. In addition, CCL19 is also able to regulate the activation and differentiation of immune cells, affecting the type and intensity of immune responses.
Recent studies have found that CCL19 is also involved in the production and maintenance of lymphatic vessels. These processes have an important impact on the migration of immune cells and the regulation of immune responses, and also provide new ideas for the treatment of some diseases related to CCL19.
Customer Reviews (3)
Write a reviewThe quality of the production is stable, and the batch-to-batch and intra-batch repeatability is good.
CCL19 has a complete range of specifications and is suitable for experiments of different scales.
The preparation is simple and we can do it ourselves.
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