ccl19
Share
  • Official Full Name
  • Chemokine (C-C motif) ligand 19
  • Background
  • Studies have shown that MIP-3B may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. In addition, this protein may play an important role in trafficking of T- cells in thymus, and T-cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. MIP-3B is expressed at high levels in the lymph nodes, thymus and appendix, intermediate levels in colon and trachea, and low levels in spleen, small intestine, lung, kidney and stomach. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7.
  • Synonyms
  • CCL19; RP11-195F19.11-003; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine 19; CC chemokine ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
Cat.#:CCL19-792MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SFRP1 Protein (Met1-Ser108), His-tagged
+Inquiry
Cat.#:CCL19-0618HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL19 Protein, GST-Tagged
+Inquiry
Cat.#:CCL19-2891HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL19 Protein
+Inquiry
Cat.#:Ccl19-0620MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl19 Protein
+Inquiry
Cat.#:CCL19-2893MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CCL19 Protein
+Inquiry
Cat.#:Ccl19-4339MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ccl19 Protein
+Inquiry
Cat.#:CCL19-4365CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine CCL19 Protein
+Inquiry
Cat.#:CCL19-4360RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CCL19 Protein
+Inquiry
Cat.#:CCL19-4359STag:
Source (Host):YeastSpecies:Swine
Product nameRecombinant Swine CCL19 Protein
+Inquiry
Cat.#:CCL19-4399MTag:
Source (Host):YeastSpecies:Monkey
Product nameRecombinant Monkey CCL19 Protein
+Inquiry
Cat.#:CCL19-154HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 19, T7-tagged
+Inquiry
Cat.#:CCL19-298HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 19
+Inquiry
Cat.#:CCL19-110HTag:
Source (Host):Species:Human
Product nameHuman CCL19
+Inquiry
Cat.#:CCL19-161HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 19, MIgG2a Fc-tagged
+Inquiry
Cat.#:CCL19-162HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 19, HIgG1 Fc-tagged, mutant
+Inquiry
Cat.#:CCL19-163HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 19, HIgG1 Fc-tagged
+Inquiry
Cat.#:CCL19-27646THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL19, T7-tagged
+Inquiry
Cat.#:CCL19-583HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CCL19
+Inquiry
Cat.#:CCL19-721HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL19 protein, His-tagged
+Inquiry
Cat.#:CCL19-2962MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCL19 Protein
+Inquiry
Cat.#:Ccl19-623MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl19
+Inquiry
Cat.#:Ccl19-722MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl19 protein, His-tagged
+Inquiry
Cat.#:Ccl19-682RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl19
+Inquiry
Cat.#:Ccl19-723RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl19 protein, His-tagged
+Inquiry
Cat.#:CCL19-371CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CCL19 Protein, His-tagged
+Inquiry
Cat.#:CCL19-720DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CCL19 protein, His & GST-tagged
+Inquiry
Cat.#:CCL19-5640CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCL19
+Inquiry
Cat.#:CCL19-7729HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCL19 293 Cell Lysate
+Inquiry

Involved Pathway

CCL19 involved in several pathways and played different roles in them. We selected most pathways CCL19 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CSF3R; EDAR; LIFRA; IFNL3; IL1RAP; TNFRSF10C; CCR1; IL1A; CCL17; PDGFAA
Chemokine signaling pathway
PRKCD; PLCB1; XCL2; LOC100033925; CCL28; STAT2; CRKL; Ccl21a; PIK3R3; CXCL9
NF-kappa B signaling pathway
BIRC3; CCL4L2; ZAP70; RIPK1; CFLAR; CARD11; TLR4; LTBR; TNFSF13B; BCL10

Protein Function

CCL19 has several biochemical functions, for example, CCR chemokine receptor binding, CCR10 chemokine receptor binding, CCR7 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL19 itself. We selected most functions CCL19 had, and list some proteins which have the same functions with CCL19. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL16; CCL34B.4; CCL34B.1; CCL22; CCL17; CCL26; CCL19A.1; CCL19A.2; CCL34A.4; CXCL32B.1
Function CCR10 chemokine receptor binding
Related Protein CXCL13; CCL25; CCL19
Function CCR7 chemokine receptor binding
Related Protein CCL21; CCL19
Function chemokine activity
Related Protein CCL18; CXCL6; CXCL16; CCL15; CCL8; CXCL14; CXCL20; CCL38A.4; CXL34B.11; CCL4
Function chemokine receptor binding
Related Protein CCL21B; CCL5; CCRL2; CXCL12; CCL19; S100A14; Ccl21c; CCL25; Ccl21a; XCL1

CCL19 Related Articles

Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
Carubbi, F; Alunno, A; et al. Is minor salivary gland biopsy more than a diagnostic tool in primary Sjogren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study. SEMINARS IN ARTHRITIS AND RHEUMATISM 44:314-324(2014).

CCL19 Related Gene Family

Chemokines Cytokines