ccl20
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  • Official Full Name
  • chemokine (C-C motif) ligand 20
  • Background
  • Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.
  • Synonyms
  • CCL20; chemokine (C-C motif) ligand 20; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; exodus-1; MIP-3-alpha; CC chemokine LARC; OTTHUMP00000164245; OTTHUMP00000204113; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; MIP-3[a]; OTTMUSP00000017965; OTTMUSP00000017966
Cat.#:CCL20-1082BTag:His-SUMO
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine CCL20 Protein (27-96 aa), His-SUMO-tagged
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Cat.#:CCL20-793MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CCL20 Protein (Ala28-Met97)
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Cat.#:CCL20-0624HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL20 Protein, GST-Tagged
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Cat.#:CCL20-22HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL20 Protein
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Cat.#:CCL20-515HTag:HIgG1 Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL20 Protein, HIgG1 Fc-tagged, mutant
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Cat.#:CCL20-516HTag:MIgG2a Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL20 Protein, MIgG2a Fc-tagged
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Cat.#:CCL20-517HTag:HIgG1 Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL20 Protein, HIgG1 Fc-tagged
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Cat.#:Ccl20-2888RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl20 Protein
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Cat.#:CCL20-4364RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CCL20 Protein
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Cat.#:Ccl20-409RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Chemokine (C-C motif) Ligand 20
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Cat.#:CCL20-161HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL20, His tagged
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Cat.#:CCL20-296HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL20
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Cat.#:CCL20-717HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL20 protein, His & GST-tagged
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Cat.#:Ccl20-833MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ccl20 Protein, His-tagged
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Cat.#:CCL20-1212RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCL20 Protein
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Cat.#:Ccl20-719RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl20 protein, His & GST-tagged
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Cat.#:CCL20-684RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCL20 Protein, His-tagged
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Cat.#:CCL20-6008CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCL20
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Cat.#:CCL20-15MTag:GST
Source (Host):E. coliSpecies:Macaca mulatta
Product nameRecombinant Macaca mulatta CCL20 protein, GST-tagged
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Cat.#:CCL20-11HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 20
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Cat.#:CCL20-50MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 20
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Cat.#:CCL20-136CTag:N/A
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken Chemokine (C-C motif) Ligand 20
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Cat.#:CCL20-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL20, His-tagged
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Cat.#:CCL20-447MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CCL20 cell lysate
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Involved Pathway

CCL20 involved in several pathways and played different roles in them. We selected most pathways CCL20 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PPBP; IL10RB; TNFRSF13C; EPOR; IL7R; CXCL10; TGFB3; CXCR7; VEGFAB; IL1R1
Chemokine signaling pathway
SOS1; AKT2; CCR7; CCL23; CCL16; WAS; CX3CL1; Adcy4; GM13304; PIK3R2
TNF signaling pathway
IL1B; RPS6KA4; TRAF5; MAPK10; MMP9; PIK3CA; PIK3R1; NFKBIA; IKBKB; ICAM1
Rheumatoid arthritis
ATP6V1B1; Il23a; Il12b; ATP6V1D; CCL3L1; ATP6V1C2; ATP6V1C1; FOS; IL17A; CCL5; CTLA4

Protein Function

CCL20 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL20 itself. We selected most functions CCL20 had, and list some proteins which have the same functions with CCL20. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL34A.4; CCL38A.4; CCL11; CCL18; CCL16; CCL19A.2; CCRL2; XCL1; CCL20A.3; CCL35.1
Function chemokine activity
Related Protein CKLF; CCL20B; CX3CL1; CCL24; CXCL16; CXCL19; CCL18; CXCL20; CCL7; CCL22
Function protein binding
Related Protein PRL2C2; ITGB1BP3; SNRPD3; SRSF5; NLGN3; CRELD2; PHF8; HIST1H3H; PSME3; APPL1

Interacting Protein

CCL20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL20 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL20.
RALBP1; TRAF6; TGFB3

CCL20 Related Articles

Qin, T; Yin, YY; et al. Whole inactivated avian Influenza H9N2 viruses induce nasal submucosal dendritic cells to sample luminal viruses via transepithelial dendrites and trigger subsequent DC maturation. VACCINE 33:1382-1392(2015).
Wu, HH; Hwang-Verslues, WW; et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. JOURNAL OF EXPERIMENTAL MEDICINE 212:333-349(2015).

CCL20 Related Gene Family

Chemokines Cytokines