CCL20 Protein, chemokine (C-C motif) ligand 20

CCL20

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CCL20

Official Full Name chemokine (C-C motif) ligand 20
Background Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.
Synonyms CCL20; chemokine (C-C motif) ligand 20; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; exodus-1; MIP-3-alpha; CC chemokine LARC; OTTHUMP00000164245; OTTHUMP00000204113; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; MIP-3[a]; OTTMUSP00000017965; OTTMUSP00000017966
    • Species :
    • Bovine
    • Chicken
    • Human
    • Macaca mulatta
    • Mouse
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • HIgG1 Fc
    • His
    • SUMO
    • MIgG2a Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine CCL20-1082B Recombinant Bovine CCL20 Protein (27-96 aa), His-SUMO-tagged E.coli His/SUMO
    Mouse CCL20-793M Recombinant Mouse CCL20 Protein (Ala28-Met97) E.coli N/A
    Human CCL20-0624H Recombinant Human CCL20 Protein, GST-Tagged Wheat Germ GST
    Human CCL20-11H Recombinant Human CCL20 protein E.coli N/A
    Human CCL20-161H Recombinant Human CCL20, His tagged E.coli His
    Human CCL20-166H Recombinant Human CCL20, His-tagged E.coli His
    Human CCL20-22H Recombinant Human CCL20 Protein CHO N/A
    Human CCL20-296H Recombinant Human CCL20 E.coli N/A
    Human CCL20-515H Recombinant Human CCL20 Protein, HIgG1 Fc-tagged, mutant CHO HIgG1 Fc
    Human CCL20-516H Recombinant Human CCL20 Protein, MIgG2a Fc-tagged CHO MIgG2a Fc
    Human CCL20-517H Recombinant Human CCL20 Protein, HIgG1 Fc-tagged CHO HIgG1 Fc
    Human CCL20-717H Recombinant Human CCL20 protein, His & GST-tagged E.coli His/GST
    Mouse CCL20-447MCL Recombinant Mouse CCL20 cell lysate Insect Cell N/A
    Mouse CCL20-50M Recombinant Mouse CCL20 protein E.coli N/A
    Mouse Ccl20-833M Recombinant Mouse Ccl20 Protein, His-tagged Insect Cell His
    Rat CCL20-1212R Recombinant Rat CCL20 Protein Mammalian Cell His
    Rat Ccl20-2888R Recombinant Rat Ccl20 Protein E.coli N/A
    Rat Ccl20-409R Recombinant Rat Chemokine (C-C motif) Ligand 20 E.coli N/A
    Rat Ccl20-719R Recombinant Rat Ccl20 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque CCL20-684R Recombinant Rhesus monkey CCL20 Protein, His-tagged Mammalian Cell His
    Chicken CCL20-136C Recombinant Chicken Chemokine (C-C motif) Ligand 20 Yeast N/A
    Rabbit CCL20-4364R Recombinant Rabbit CCL20 Protein Yeast N/A
    Chicken CCL20-6008C Recombinant Chicken CCL20 Mammalian Cell His
    Macaca mulatta CCL20-15M Recombinant Macaca mulatta CCL20 protein, GST-tagged E.coli GST

    CCL20 involved in several pathways and played different roles in them. We selected most pathways CCL20 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction Ccl12; BMPR2A; CXCL1; IFNB; IFNE; IL12B; CXCR7; TNFRSF11A; PF4V1; FLT4
    Chemokine signaling pathway GNAI1; RAF1; WASL; CXCR2; PIK3CA; STAT1; GRK4; CCL4L2; PIK3R5; CCR6
    TNF signaling pathway BIRC3; CXCL3; TRAF1; PIK3CA; PIK3CD; PIK3CG; MAGI2; CCL2; BCL3; CREB3L3
    Rheumatoid arthritis HLA-DOA; ITGAL; GM-CSF; TLR4; TNF; ATP6V0A2; H2-AA; ATP6V1C2; H2-AB1; ICAM1

    CCL20 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL20 itself. We selected most functions CCL20 had, and list some proteins which have the same functions with CCL20. You can find most of the proteins on our site.

    Function Related Protein
    CCR chemokine receptor binding CXCL32B.1; CCL33.3; CCL16; CCRL2; CCL14; CCL24; CCL19; CCL13; CCL19A.1; CCL34A.4
    chemokine activity CKLF; CCL3L1; CXCL11.8; Ccl12; CXCL8B.3; CCL19; CCL38.1; Ccl21a; CCL34B.1; CCL25B
    protein binding CHMP4C; THAP10; SIGLEC8; HTR1E; NPHP3; MARK3; MORF4L1; DDX6; MST1R; GNB3

    CCL20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL20 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL20.

    RALBP1; TRAF6; TGFB3

    Qin, T; Yin, YY; et al. Whole inactivated avian Influenza H9N2 viruses induce nasal submucosal dendritic cells to sample luminal viruses via transepithelial dendrites and trigger subsequent DC maturation. VACCINE 33:1382-1392(2015).
    Wu, HH; Hwang-Verslues, WW; et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. JOURNAL OF EXPERIMENTAL MEDICINE 212:333-349(2015).

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