DKK1
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Official Full Name
dickkopf WNT signaling pathway inhibitor 1 -
Overview
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008] -
Synonyms
DKK1;dickkopf WNT signaling pathway inhibitor 1;SK;DKK-1;dickkopf-related protein 1;hDkk-1;dickkopf-1 like;dickkopf 1 homolog;dickkopf-like protein 1;dickkopf related protein-1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Cynomolgus/Rhesus macaque
- Rat
- E.coli
- Human Cells
- HEK293
- Sf21 Cells
- Insect Cells
- CHO
- Mammalian Cells
- C-His
- C-hFc-Avi
- Hi-5 Insect Cells
- Rabbit
- In Vitro Cell Free System
- GST
- Fc
- His
- Avi
- Non
- Flag
- SUMO
- MBP
Involved Pathway
DKK1 involved in several pathways and played different roles in them. We selected most pathways DKK1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | TLE3A,SFRP2,WNT16,MAPK8,DVL3A,TCF7L2,WNT8A,SMAD4,PRKACB,SMAD3 |
Protein Function
DKK1 has several biochemical functions, for example, co-receptor binding,growth factor activity,low-density lipoprotein particle receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DKK1 itself. We selected most functions DKK1 had, and list some proteins which have the same functions with DKK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| low-density lipoprotein particle receptor binding | APOEA,DNAJA1,LRP2,PCSK9,APOEB,MESDC2,ARRB2,AP2M1,LDLRAP1,APOE |
| signal transducer activity | HCAR1-1,GNAO1B,OLFR508,CELSR3,OMP,ASZ1,TAAR10C,CANT1,SHISA5,TAAR8B |
| growth factor activity | PRL2C2,FGF1A,THBS4B,FGF5,AMH,AMELX,TFF1,KITLG,BMP2,Kitl |
| co-receptor binding | HFE,NEO1,TFR2,BMP2,BMP4 |
| receptor antagonist activity | AGTR2,ESR2,LRPAP1,ADH7,IL18BP |
| protein binding | STK38L,ASH2L,PRMT2,ORAI2,AEBP2,KIF7,MEF2A,ACACB,SEPT7,NMU |
Interacting Protein
DKK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKK1.
MDFI;386677;LRP6;CORO1A;CTNNB1;SMAD9;DPP4
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References
- Jin, HT; Wang, BL; et al. Anti-DKK1 antibody promotes bone fracture healing through activation of beta-catenin signaling. BONE 71:63-75(2015).
- Gerbaix, M; Vico, L; et al. Periostin expression contributes to cortical bone loss during unloading. BONE 71:94-100(2015).
