Recombinant Human DKK1 protein, His-Avi-tagged

• Cat.No.: DKK1-907H
• Product Overview: Human DKK1 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Thr32-His266.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: Thr32-His266
• Description: Dickkopf related protein 1(Dkk-1) is the founding member of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy. Dkk proteins are secreted proteins that contain two conserved cysteine-rich domains separated by a linker region. Dkk antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 28.5 Kda.
• Endotoxin: Less than 1EU per ug by the LAL method.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: DKK1
• Official Symbol: DKK1
• Synonyms: dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-related protein 1; Dkk1; Dkk-1; hDkk-1; SKdickkopf-1 like
• Gene ID: 22943
• mRNA Refseq: NM_012242.4
• Protein Refseq: NP_036374.1
• MIM: 605189
• UniProt ID: O94907