GDF15

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GDF15

Official Full Name growth differentiation factor 15
Background Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
Synonyms GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GDF15-284H Recombinant Human GDF15 protein, His-tagged E.coli His
    Human GDF15-285H Recombinant Human GDF15 protein, His-tagged E.coli His
    Mouse Gdf15-7379M Recombinant Mouse Gdf15 Protein, His-tagged E.coli His
    Human GDF15-204H Recombinant Human GDF15, Fc tagged Human Cell Fc
    Human GDF15-20H Recombinant Human GDF15 protein, His-tagged Yeast His
    Human GDF15-243H Recombinant Human Growth Differentiation Factor 15 N/A
    Human GDF15-246H Recombinant Human GDF15 protein E.coli N/A
    Human GDF15-268H Recombinant Human GDF15 E.coli N/A
    Human GDF15-2705HCL Recombinant Human GDF15 cell lysate Human Cell N/A
    Human GDF15-27680TH Native Human GDF15 Protein N/A
    Human GDF15-28170TH Recombinant Human GDF15, His-tagged E.coli His
    Human GDF15-337H Recombinant Human Growth Differentiation Factor 15 CHO N/A
    Human GDF15-362H Recombinant Human Growth Differentiation Factor 15 E.coli N/A
    Human GDF15-4821H Recombinant Human GDF15 Protein CHO N/A
    Human GDF15-4822H Recombinant Human GDF15 Protein, GST-tagged Wheat Germ GST
    Human GDF15-626H Recombinant Human Growth Differentiation Factor 15, His-tagged Human His
    Mouse Gdf15-26M Recombinant Mouse Gdf15 protein, His-tagged E.coli His
    Mouse Gdf15-392M Recombinant Mouse Gdf15 protein, His-tagged E.coli His
    Mouse Gdf15-393M Recombinant Mouse Gdf15 protein E.coli N/A
    Mouse GDF15-6285M Recombinant Mouse Gdf15 protein, His-tagged HEK293 His
    Rat GDF15-2502R Recombinant Rat GDF15 Protein Mammalian Cell His
    Rat Gdf15-26R Recombinant Rat Gdf15 Protein, His-tagged E.coli His

    GDF15 involved in several pathways and played different roles in them. We selected most pathways GDF15 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Direct p53 effectors ARID3A; DUSP5; S100A2; EPHA2; RNF144B; ZNF385A; CD82; DDX5; PLK3; BCL2L14

    GDF15 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF15 itself. We selected most functions GDF15 had, and list some proteins which have the same functions with GDF15. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity GDF10B; EDN1; IFNT2; IFNA2; TNFRSF11B; NDR1; IFNPHI2; IL21; SP100; TGFB3
    growth factor activity DKK1; BMP4; CDNF; NUDT6; BMP5; FGF20A; MACC1; NRTN; REG1A; NRG1
    transforming growth factor beta receptor binding MSTNB; BMP10; SMAD2; GDF1; GDF9; GDF5; GDF10B; INHBE; NODAL; GDF7

    GDF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF15.

    MDFI; MAPK14; Trip11; ssrna_a; STAT5A; Smn1; Cdc37; MRPL50; NUPL1; SETD4; SAE1

    von der Heyde, S; Wagner, S; et al. mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLOS ONE 10:-(2015).
    Hinoi, E; et al. Regulation of Osteoclastogenesis by Osteocytes through Growth Differentiation Factor-15. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 134:1259-1263(2014).

    TGF

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