|Official Full Name||growth differentiation factor 15|
|Background||Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]|
|Synonyms||GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
GDF15 involved in several pathways and played different roles in them. We selected most pathways GDF15 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Direct p53 effectors||ARID3A; DUSP5; S100A2; EPHA2; RNF144B; ZNF385A; CD82; DDX5; PLK3; BCL2L14|
GDF15 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF15 itself. We selected most functions GDF15 had, and list some proteins which have the same functions with GDF15. You can find most of the proteins on our site.
|cytokine activity||GDF10B; EDN1; IFNT2; IFNA2; TNFRSF11B; NDR1; IFNPHI2; IL21; SP100; TGFB3|
|growth factor activity||DKK1; BMP4; CDNF; NUDT6; BMP5; FGF20A; MACC1; NRTN; REG1A; NRG1|
|transforming growth factor beta receptor binding||MSTNB; BMP10; SMAD2; GDF1; GDF9; GDF5; GDF10B; INHBE; NODAL; GDF7|
GDF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF15.
MDFI; MAPK14; Trip11; ssrna_a; STAT5A; Smn1; Cdc37; MRPL50; NUPL1; SETD4; SAE1