gdf15
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  • Official Full Name
  • growth differentiation factor 15
  • Background
  • Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
  • Synonyms
  • GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
Cat.#:GDF15-284HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human GDF15 protein, His-tagged
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Cat.#:GDF15-285HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human GDF15 protein, His-tagged
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Cat.#:GDF15-4821HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GDF15 Protein
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Cat.#:GDF15-4822HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GDF15 Protein, GST-tagged
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Cat.#:GDF15-243HTag:N/A
Source (Host):Cell cultureSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 15
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Cat.#:GDF15-204HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDF15, Fc tagged
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Cat.#:GDF15-20HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GDF15 protein, His-tagged
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Cat.#:GDF15-246HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF15 protein
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Cat.#:GDF15-268HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF15
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Cat.#:GDF15-28170THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF15, His-tagged
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Cat.#:GDF15-337HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 15
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Cat.#:GDF15-362HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 15
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Cat.#:Gdf15-26MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf15 protein, His-tagged
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Cat.#:Gdf15-392MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf15 protein, His-tagged
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Cat.#:Gdf15-393MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf15 protein
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Cat.#:GDF15-6285MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gdf15 protein, His-tagged
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Cat.#:GDF15-2502RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GDF15 Protein
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Cat.#:Gdf15-26RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gdf15 Protein, His-tagged
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Cat.#:GDF15-626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 15, His-tagged
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Cat.#:GDF15-27680THTag:N/A
Source (Host):Cell CultureSpecies:Human
Product nameNative Human GDF15 Protein
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Cat.#:GDF15-2705HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDF15 cell lysate
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Involved Pathway

GDF15 involved in several pathways and played different roles in them. We selected most pathways GDF15 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Direct p53 effectors
BNIP3L; PLK3; CEBPZ; DDX5; CTSD; PRDM1; GDF15; TRIAP1; DUSP5; GADD45A

Protein Function

GDF15 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF15 itself. We selected most functions GDF15 had, and list some proteins which have the same functions with GDF15. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IFNB; LEFTY1; IFNA8; IFNA16; Kitl; INHBAB; IL29; IFNT2; CMTM6; IFNPHI1
Function growth factor activity
Related Protein FIGF; IL34; PROK1; CDNF; IL8L2; MSTNB; NDR2; LEP; TGFB2; INHBAA
Function transforming growth factor beta receptor binding
Related Protein GDF9; SPAW; BMP3; INHBAB; BMP15; GDF5; GDF2; BMP7; NDR2; GDF10B

Interacting Protein

GDF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF15.
MDFI; MAPK14; Trip11; ssrna_a; STAT5A; Smn1; Cdc37; MRPL50; NUPL1; SETD4; SAE1

GDF15 Related Articles

von der Heyde, S; Wagner, S; et al. mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLOS ONE 10:-(2015).
Hinoi, E; et al. Regulation of Osteoclastogenesis by Osteocytes through Growth Differentiation Factor-15. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 134:1259-1263(2014).

GDF15 Related Gene Family

TGF