GH1 Protein, growth hormone 1


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Official Full Name growth hormone 1
Background The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Synonyms gH; GH-N; GH1; GHN; Growth hormone 1; Growth hormone; Growth hormone, normal; Growth hormone, pituitary; HG1; hGH-N; IGHD1B; Pituitary growth hormone; RNGHGP; SOMA_HUMAN; Somatotropin
    • Species :
    • Bovine
    • Chicken
    • Dog
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293EBNA1
    • HEK293F
    • Human
    • Human Cell
    • Human Pituitary Gland
    • Mammalian Cell
    • Nicotiana Benthamiana
    • Wheat Germ
    • Zebrafish
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • T7
    • Met
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GH1-007H Recombinant Human GH1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human GH1-2010H Recombinant Human GH1 Protein, His-tagged E.coli His
    Human GH1-002N Recombinant Human Growth Hormone 1 (Active) , His-tagged Nicotiana Benthamiana His
    Human GH1-132H Recombinant Human GH1 Active Nicotiana Benthamiana N/A
    Human GH1-1553H Recombinant human GH1, Active Nicotiana Benthamiana N/A
    Human GH1-240H Recombinant Human GH1 (27-217aa) Human N/A
    Human GH1-241H Recombinant Human GH1 (1-217aa) Human N/A
    Human GH1-263H Recombinant Human GH1, StrepII-tagged Human Cell Strep II
    Human GH1-28093TH Recombinant Human GH1 protein E.coli N/A
    Human GH1-382H Recombinant Human Growth Hormone 1, His-tagged His
    Human GH1-457H Recombinant Human GH1 protein, His-tagged HEK293F His
    Human GH1-462H Recombinant Human GH1, Met-tagged E.coli Met
    Human GH1-4882H Recombinant Human GH1 Protein, His-tagged HEK293EBNA1 His
    Human GH1-4883H Recombinant Human GH1 Protein, GST-tagged Wheat Germ GST
    Human GH1-5354H Native Human Growth Hormone 1 Human Pituitary Gland N/A
    Human GH1-5944HCL Recombinant Human GH1 293 Cell Lysate HEK293 N/A
    Human GH1-63H Human Growth Hormone Reference standard N/A
    Human GH1-641H Recombinant Human Growth Hormone 1 Human N/A
    Human GH1-76H Recombinant Human Growth Hormone E.coli N/A
    Human GH1-770H Recombinant Human GH1 Protein E.coli N/A
    Human GH1-77H Recombinant Human 20 kDa Growth Hormone E.coli N/A
    Human GH1-782H Recombinant Human GH1 protein, His-tagged E.coli His
    Human GH1-80H Recombinant Human Growth Hormone 1 HEK293 N/A
    Human GH1-8147H Native Growth Hormone (GH) Human Pituitary Gland N/A
    Human GH1-9161H Recombinant Human GH1, His-tagged E.coli His
    Human GH-P016H Recombinant Human GH1 therapeutic protein E.coli N/A
    Rat Gh1-163R Recombinant Rat Growth Hormone E.coli N/A
    Rat Gh1-372R Recombinant Rat Growth Hormone 1 E.coli N/A
    Rat Gh1-784R Recombinant Rat Gh1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque GH1-1842R Recombinant Rhesus monkey GH1 Protein, His-tagged Mammalian Cell His
    Dog GH1-781D Recombinant Dog GH1 protein, His & T7-tagged E.coli His/T7
    Bovine GH1-183B Recombinant Bovine Growth Hormone E.coli N/A
    Chicken GH1-144C Recombinant Chicken Growth Hormone Mutant G119R E.coli N/A
    Chicken GH1-30C Recombinant Chicken Growth Hormone 1 E.coli N/A
    Zebrafish GH1-2692Z Recombinant Zebrafish GH1 Mammalian Cell His
    Zebrafish gh1-644Z Recombinant Zebrafish Growth Hormone 1 Zebrafish N/A

    GH1 involved in several pathways and played different roles in them. We selected most pathways GH1 participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction NGFR; IL13RA1; IL1B; CRLF2; CXCL2; CCL23; Flt3l; IFNGR2; TGFBR1B; IL18
    Neuroactive ligand-receptor interaction HTR1F; PTGER1C; HTR1E; GABRP; S1PR5A; TAAR10B; TAAR6; ADRB2A; CRHR2; P2RY10
    PIK-Akt signaling pathway LAMB1; FGF14; CREB3L2; GNG13; GNG5; GNGT1; PDGFC; YWHAZ; ITGA9; IL4
    Jak-STAT signaling pathway IL20RA; CSF3R; Il4ra; AOX4; STAT5B; PRLRA; IL21R.1; HRASA; CRFB4; JAK2B

    GH1 has several biochemical functions, for example, growth factor activity, growth hormone receptor binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GH1 itself. We selected most functions GH1 had, and list some proteins which have the same functions with GH1. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity BMP4; FGF1; GDF7; BTC; MANF; IL8L2; Artn; FGF18A; IL11; PDGFAA
    growth hormone receptor binding SOCS2; GH1; JAK1; JAK2; Gh; TYK2
    hormone activity CRHR2; INS1; GNRH1; SMTLB; FNDC5B; PTHLH; PTH1B; PRL2; EDN3; ADCYAP1A
    metal ion binding ATP2B1; CYGB2; ZNF613; GCM2; ZFP35; ZFP110; SP5L; BCMO1; TRIM35-21; ATF7
    prolactin receptor binding HSD17B7; PRL4A1; GH1; PRL
    protein binding FKBP4; DEPDC6; WBP2NL; TSKS; CCL28; RPS27A; NOC4L; ESRP1; CALB1; AGPAT5

    GH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GH1.


    Low, JGH; Lee, LS; et al. Safety and immunogenicity of a virus-like, particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers. VACCINE 32:5041-5048(2014).
    Kedzial, A; Tarka, A; et al. Placental growth hormone (PGH), pituitary growth hormone (GH1), insulin-like growth factor (IGF-I) and ghrelin in pregnant women's blood serum. GINEKOLOGIA POLSKA 84:620-623(2013).

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