gh1
Share
  • Official Full Name
  • growth hormone 1
  • Background
  • The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
  • Synonyms
  • gH; GH-N; GH1; GHN; Growth hormone 1; Growth hormone; Growth hormone, normal; Growth hormone, pituitary; HG1; hGH-N; IGHD1B; Pituitary growth hormone; RNGHGP; SOMA_HUMAN; Somatotropin
Cat.#:GH1-2010HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1 Protein, His-tagged
+Inquiry
Cat.#:GH1-4882HTag:His
Source (Host):HEK293EBNA1Species:Human
Product nameRecombinant Human GH1 Protein, His-tagged
+Inquiry
Cat.#:GH1-4883HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GH1 Protein, GST-tagged
+Inquiry
Cat.#:GH1-9161HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1, His-tagged
+Inquiry
Cat.#:GH1-76HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Hormone
+Inquiry
Cat.#:GH1-77HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human 20 kDa Growth Hormone
+Inquiry
Cat.#:GH1-80HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Growth Hormone 1
+Inquiry
Cat.#:Gh1-163RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Growth Hormone
+Inquiry
Cat.#:GH1-30CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Growth Hormone 1
+Inquiry
Cat.#:GH1-240HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1 (27-217aa)
+Inquiry
Cat.#:GH1-241HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1 (1-217aa)
+Inquiry
Cat.#:Gh1-372RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Growth Hormone 1
+Inquiry
Cat.#:GH1-132HTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human GH1 Active
+Inquiry
Cat.#:GH1-1553HTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human GH1, Active
+Inquiry
Cat.#:GH1-263HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human GH1, StrepII-tagged
+Inquiry
Cat.#:GH1-28093THTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human GH1 protein
+Inquiry
Cat.#:GH1-457HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GH1 protein, His-tagged
+Inquiry
Cat.#:GH1-462HTag:Met
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1, Met-tagged
+Inquiry
Cat.#:GH1-770HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1 Protein
+Inquiry
Cat.#:GH1-782HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1 protein, His-tagged
+Inquiry
Cat.#:Gh1-784RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gh1 protein, His & T7-tagged
+Inquiry
Cat.#:GH1-1842RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GH1 Protein, His-tagged
+Inquiry
Cat.#:GH1-781DTag:His|T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog GH1 protein, His & T7-tagged
+Inquiry
Cat.#:GH1-2692ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GH1
+Inquiry
Cat.#:GH1-183BTag:N/A
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Growth Hormone
+Inquiry
Cat.#:GH1-641HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Hormone 1
+Inquiry
Cat.#:GH1-144CTag:N/A
Source (Host):Species:Chicken
Product nameRecombinant Chicken Growth Hormone Mutant G119R
+Inquiry
Cat.#:gh1-644ZTag:N/A
Source (Host):E. coliSpecies:Zebrafish
Product nameRecombinant Zebrafish Growth Hormone 1
+Inquiry
Cat.#:GH1-002NTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Growth Hormone 1 (Active) , His-tagged
+Inquiry
Cat.#:GH1-382HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Growth Hormone 1, His-tagged
+Inquiry
Cat.#:GH1-5354HTag:N/A
Source (Host):Human pituitary glandsSpecies:Human
Product nameNative Human Growth Hormone 1
+Inquiry
Cat.#:GH1-8147HTag:N/A
Source (Host):Human pituitary glandsSpecies:Human
Product nameNative Growth Hormone (GH)
+Inquiry
Cat.#:GH1-5944HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GH1 293 Cell Lysate
+Inquiry
Cat.#:GH1-63HTag:N/A
Source (Host):Species:Human
Product nameHuman Growth Hormone Reference standard
+Inquiry
Cat.#:GH-P016HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GH1 therapeutic protein
+Inquiry

Involved Pathway

GH1 involved in several pathways and played different roles in them. We selected most pathways GH1 participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
Ccl9; CRFB2; CCL19; CCR8L; CSH; LEPR; CLCF1; IL11; CXCR6; GM13304
Neuroactive ligand-receptor interaction
CHRNB2; GH1; DRD1A; LPAR2; APLNR; CHRNA4; HTR1A; GRIA3; P2RX3A; PTGER1A
PIK-Akt signaling pathway
COL27A1; CREB3L2; ITGB6; IL3RA; Il4ra; TEK; PPP2R3A; PDGFA; GNB4; GNG5
Jak-STAT signaling pathway
PRLRA; IL7; PIAS4A; FHL1B; PIM1; GFAP; CSF3; IFNA10; EP300; PRP2

Protein Function

GH1 has several biochemical functions, for example, growth factor activity, growth hormone receptor binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GH1 itself. We selected most functions GH1 had, and list some proteins which have the same functions with GH1. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein FGF6; NRG4; BTC; GDF3; INHA; MSTNB; NTF3; INHBAB; FGF16; GDF5
Function growth hormone receptor binding
Related Protein JAK2; SOCS2; TYK2; GH1; Gh; JAK1
Function hormone activity
Related Protein UTS2; Gh; STC2A; LEPB; PRL2; INS1; C1QTNF9; PRL2C2; SST2; CSHL1
Function metal ion binding
Related Protein RSAD2; TRPM6; AGFG1B; DTD1; ARSG; ZDHHC16B; TIMM8B; RNF17; ZFP30; RACGAP1
Function prolactin receptor binding
Related Protein PRL; HSD17B7; GH1; PRL4A1
Function protein binding
Related Protein HCST; MSRB3; DSC2; THBD; NEDD8; CEP57L1; KRTAP4-2; UCP2; LRRC7; YARS2

Interacting Protein

GH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GH1.
GHR; PRLR; 5730104; PSMD12; PSMD3; DNAJB6; CSDE1; DNAJC8; GOT2; NPM1; ANXA2; APRT; HNRNPC; RHOC; LTA4H

GH1 Related Articles

Low, JGH; Lee, LS; et al. Safety and immunogenicity of a virus-like, particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers. VACCINE 32:5041-5048(2014).
Kedzial, A; Tarka, A; et al. Placental growth hormone (PGH), pituitary growth hormone (GH1), insulin-like growth factor (IGF-I) and ghrelin in pregnant women's blood serum. GINEKOLOGIA POLSKA 84:620-623(2013).