gpc3
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  • Official Full Name
  • glypican 3
  • Background
  • Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Recently, GPC3 was identified to be useful tumor marker for the diagnosis of HCC, hepatoblastoma, melanoma, testicular germ cell tum
  • Synonyms
  • GPC3; glypican 3; SDYS; glypican-3; DGSX; glypican proteoglycan 3; OCI 5; SGB; SGBS; SGBS1; secreted glypican-3; intestinal protein OCI-5; heparan sulphate proteoglycan; MXR7; OCI-5; GTR2-2
Cat.#:GPC3-2551HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 protein, His-tagged
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Cat.#:Gpc3-120MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gpc3 protein, Fc-tagged, APC labeled
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Cat.#:Gpc3-120MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gpc3 protein, Fc-tagged, R-PE labeled
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Cat.#:GPC3-2246HATag:His
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human GPC3 protein, His-tagged, APC labeled
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Cat.#:GPC3-2246HPTag:His
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human GPC3 protein, His-tagged, R-PE labeled
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Cat.#:GPC3-2247HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 Protein, His-Avi-tagged, Biotinylated
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Cat.#:GPC3-337HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 Protein (Gln 25 - His 559), Fc-tagged, low endotoxin
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Cat.#:GPC3-338HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 Protein (Gln 25 - His 559), Fc-tagged, FITC-Labeled
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Cat.#:GPC3-50CATag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus GPC3 protein, Fc-tagged, APC labeled
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Cat.#:GPC3-50CPTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus GPC3 protein, Fc-tagged, R-PE labeled
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Cat.#:GPC3-620HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 protein, Fc-tagged, APC labeled
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Cat.#:GPC3-620HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 protein, Fc-tagged, R-PE labeled
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Cat.#:GPC3-5147HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GPC3 Protein, GST-tagged
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Cat.#:GPC3-2246HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3, His tagged
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Cat.#:GPC3-27455THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GPC3
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Cat.#:GPC3-50HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GPC3
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Cat.#:GPC3-5683HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPC3 protein, His & GST-tagged
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Cat.#:GPC3-619HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human GPC3, Fc-tagged, Biotinylated
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Cat.#:GPC3-620HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human GPC3, Fc-tagged
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Cat.#:Gpc3-1118MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gpc3 protein, His-tagged
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Cat.#:Gpc3-120MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gpc3 Protein, Fc-tagged
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Cat.#:Gpc3-506MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Gpc3, His-tagged
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Cat.#:Gpc3-5627MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Gpc3, His-tagged
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Cat.#:Gpc3-5684MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gpc3 protein, His & T7-tagged
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Cat.#:GPC3-2633RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gpc3 protein, His-tagged
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Cat.#:GPC3-1117CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus GPC3 protein, His-tagged
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Cat.#:GPC3-50CTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus GPC3 Protein, Fc-tagged
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Cat.#:GPC3-2538HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPC3 cell lysate
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Cat.#:GPC3-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse GPC3 cell lysate
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Involved Pathway

GPC3 involved in several pathways and played different roles in them. We selected most pathways GPC3 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteoglycans in cancer
MRAS; IGF1; PPP1CB; FLNA; PIK3CA; PRKACB; PIK3CG; MAP2K1; PRKCG; ANK1

Protein Function

GPC3 has several biochemical functions, for example, heparan sulfate proteoglycan binding, peptidyl-dipeptidase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPC3 itself. We selected most functions GPC3 had, and list some proteins which have the same functions with GPC3. You can find most of the proteins on our site.
Function
Related Protein
Function heparan sulfate proteoglycan binding
Related Protein Itgam&Itgb2; FST; AGRN; ITGAM; HPSE2; SEMA5A; AZU1; GPC3; GPC1B; COMP
Function peptidyl-dipeptidase inhibitor activity
Related Protein GPC3
Function protein binding
Related Protein SCMH1; SPRR3; BTG2; ENOX1; PMM1; ZBTB2; RFFL; SNF8; BATF3; LRCH3

Interacting Protein

GPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPC3.
APPL1

GPC3 Related Articles

Zaghloul, RA; El-Shishtawy, MM; et al. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. EUROPEAN JOURNAL OF PHARMACOLOGY 746:353-362(2015).
Tretiakova, M; Zynger, DL; et al. Glypican 3 overexpression in primary and metastatic Wilms tumors. VIRCHOWS ARCHIV 466:67-76(2015).