hgf
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  • Official Full Name
  • hepatocyte growth factor (hepapoietin A; scatter factor)
  • Background
  • Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.
  • Synonyms
  • SF; HGFB; HPTA; F-TCF; DFNB39;Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor beta chain; Hepatocyte growth factor precursor; Hepatopoeitin-A; Hepatopoietin A; Hgf; Lung fibroblast derived mitogen; OTTHUMP00000161349; OTTHUMP00000206710; OTTHUMP00000206711; OTTHUMP00000206712; OTTHUMP00000206713; OTTHUMP00000206730; Scatter factor; Rilotumumab; 872514-65-3; Flanvotumab; 1188277-05-5
Cat.#:HGF-13HTag:N/A
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human HGF Propeptide Protein
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Cat.#:HGF-254HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HGF Protein, MYC/DDK-tagged
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Cat.#:HGF-4726HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGF Protein
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Cat.#:HGF-4728HTag:N/A
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human HGF Protein
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Cat.#:HGF-4729HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HGF Protein, GST-tagged
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Cat.#:Hgf-257MTag:N/A
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Hgf Protein
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Cat.#:Hgf-4731MTag:N/A
Source (Host):Insect CellSpecies:Mouse
Product nameRecombinant Mouse Hgf Protein
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Cat.#:Hgf-1237RTag:GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hgf Protein, GST-tagged
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Cat.#:HGF-592HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)
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Cat.#:HGF-341HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human HGF
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Cat.#:HGF-195HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human HGF protein
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Cat.#:HGF-225HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGF
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Cat.#:HGF-27731THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGF, His-tagged
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Cat.#:HGF-290HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HGF
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Cat.#:HGF-364HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HGF, His tagged
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Cat.#:HGF-501HTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human HGF
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Cat.#:HGF-593HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HGF, His-tagged
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Cat.#:HGF-6HTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human HGF
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Cat.#:HGF-792HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGF protein, His & T7-tagged
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Cat.#:HGF-793HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGF protein, His & GST-tagged
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Cat.#:HGF-8535HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HGF
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Cat.#:HGF-872HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HGF, None tagged
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Cat.#:Hgf-599MTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Hgf
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Cat.#:Hgf-794MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hgf protein, His-tagged
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Cat.#:Hgf-8664MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Hgf, His tagged
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Cat.#:Hgf-8665MTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Hgf, None tagged
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Cat.#:HGF-2836RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HGF Protein
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Cat.#:Hgf-795RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hgf protein, His-tagged
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Cat.#:Hgf-8806RTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Hgf, None tagged
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Cat.#:HGF-152CTag:Fc|His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus HGF, None tagged
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Cat.#:HGF-1045CTag:N/A
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine HGF Protein
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Cat.#:HGF-791DTag:His|T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog HGF protein, His & T7-tagged
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Cat.#:HGF-2239CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HGF
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Cat.#:HGF-796RTag:His|T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit HGF protein, His & T7-tagged
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Cat.#:HGF-123HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Hepatocyte Growth Factor (Hepapoietin A; Scatter factor)
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Cat.#:HGF-226HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGF, 495-728aa, His-tagged
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Cat.#:HGF-543HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Hepatocyte Growth Factor
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Cat.#:HGF-627HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Hepatocyte Growth Factor
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Cat.#:Hgf-728MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Hepatocyte Growth Factor, His-tagged
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Cat.#:Hgf-734MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Hepatocyte Growth Factor
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Cat.#:HGF-29231THTag:N/A
Source (Host):Species:Human
Product nameNative Human HGF
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Cat.#:HGF-38PTag:N/A
Source (Host):Species:Pig
Product nameNative Porcine HGF
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Cat.#:HGF-001HCLTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HGF cell lysate
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Cat.#:HGF-1210MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse HGF cell lysate
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Cat.#:HGF-1233RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat HGF cell lysate
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Cat.#:HGF-1077CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus HGF cell lysate
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Cat.#:HGF-143HGTag:N/A
Source (Host):NS0Species:Human
Product nameGMP Recombinant Human HGF Protein
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Cat.#:HGF-157HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameHuman Hepatocyte Growth Factor(precursor, rDNA derived) Reference standard
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Cat.#:HGF-158HTag:N/A
Source (Host):CHOSpecies:Human
Product nameHuman Hepatocyte Growth Factor(rDNA derived) Reference standard
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Involved Pathway

HGF involved in several pathways and played different roles in them. We selected most pathways HGF participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
GNG4; FGF20; RASGRP3; GNB4; MAPK9; PLCG1; PLA2G2E; NGF; PIK3R5; PLA2G6
Rap signaling pathway
FIGF; LAT; ITGB2; PLCG1; MAPK11; INSR; FGF1; PIK3CB; F2R; PRKCZ
Cytokine-cytokine receptor interaction
IL5RA; CSF3; CXCR3.2; FAS; LTB; IL3; BMPR1B; PDGFC; CCR9; IFNA8
PIK-Akt signaling pathway
FLT4; FGFR2; SGK1; IGF1; PDGFC; PPP2R1B; FOXO3; MCL1; NR4A1; GH2
Focal adhesion
ITGA2B; CDC42L2; ACTB; RAC1; MYL2B; COL1A1; KDRL; PAK4; VAV1; VASP
Malaria
LRP1; GYPA; IFNG; CCL2; HBA1; COMP; HBB-B1; KLRB1; KLRK1; CD36
Pathways in cancer
RXRG; IGF1R; FIGF; PTCH2; RALBP1; BIRC7; PRKACG; PTK2; RB1; PLCB3
Proteoglycans in cancer
PPP1R12A; PIK3CB; ITGB1; TFAP4; KRAS; ELK1; SDC4; WNT4; ANK2; PXN
Renal cell carcinoma
PDGFB; EPAS1; MET; RAP1B; RAF1; PIK3R1; AKT2; PTPN11; ARNT2; GRB2
Melanoma
HRAS; PIK3R2; AKT2; FGF14; FGF1; CDH1; FGF18; TRP53; RAF1; PIK3R1

Protein Function

HGF has several biochemical functions, for example, chemoattractant activity, growth factor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGF itself. We selected most functions HGF had, and list some proteins which have the same functions with HGF. You can find most of the proteins on our site.
Function
Related Protein
Function chemoattractant activity
Related Protein FGF2; HGF; NTF3; HMGB2; CCL15; SCG2; SAA2; SAA3; CCL5; CXCL12B
Function growth factor activity
Related Protein MSTNA; GDF6B; GRN; VEGFA; BMP7B; KITLG; FGF24; Artn; IGF2B; OSM
Function identical protein binding
Related Protein AKT1; JMJD6; SH3BP4; IL12B; EPS15; SAFB2; ZNF212; PLN; NUDT16; SMN2
Function protein binding
Related Protein IRF6; SRSF10; MYLK2; NFKB2; ATG5; MYH7B; COPS7B; CALB1; GPR85; AGO2
Function protein heterodimerization activity
Related Protein PPP3CB; H2AFVA; PDSS2; HER5; CHRNA5; SCGB2A1; PRMT8; HNF1B; HIST1H2BP; MICU1
Function serine-type endopeptidase activity
Related Protein KLK8; TPP2; TPSB2; PLG; CTSC; GZME; PARLA; TMPRSS4A; ELANE; GZMF
Function NOT serine-type endopeptidase activity
Related Protein RHBDF2; RHBDF1; HGF

Interacting Protein

HGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HGF.
MET; MEOX2; Met; ADAMTSL4; SRPX2; Hgf; FN1; CD44

HGF Related Articles

Pena-Silva, RA; Chalouhi, N; et al. Novel Role for Endogenous Hepatocyte Growth Factor in the Pathogenesis of Intracranial Aneurysms. HYPERTENSION 65:587-593(2015).
Wang, YQ; Fukuda, T; et al. Loss of alpha 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling. SCIENTIFIC REPORTS 5:-(2015).