ifna2
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  • Official Full Name
  • IFNA2 interferon, alpha 2
  • Background
  • Interferon alpha (IFN alpha) is a glycosylated protein which is produced by many cell types such as monocytes, macrophages, ?broblasts in response to virus infection, nucleic acid induction, glucocorticoid hormones. Some of the other biological effects, including antitumor and immunomodulatory activities IFN-alpha ’s most important function is the antiviral activity. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides. Some other biological processes involving IFN alpha are:induction of apoptosis, signal transduction, in?ammatory response. IFN alpha activates cytotoxic T-cells. IFN alpha binds to its receptors, which upon dimerisation, activate the JAK-STAT pathway.
  • Synonyms
  • IFNA2; interferon, alpha 2; interferon alpha-2; alpha 2a interferon; IFN alphaA; IFNA; interferon alpha 2b; interferon alpha A; leIF A; IFN-alpha-2; alpha-2a interferon; INFA2; IFNA2B; IFN-alphaA; MGC125764; MGC125765
Cat.#:IFNA2-1188HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNA2 Protein, MYC/DDK-tagged
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Cat.#:IFNA2-1555HTag:His
Source (Host):Nicotiana Sp.PlantSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His-tagged
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Cat.#:IFNA2-05HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pegylated Interferon Alpha-2b
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Cat.#:IFNA2-91HTag:N/A
Source (Host):PseudomonasputidaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2
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Cat.#:IFNA2-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pegylated Interferon Alpha-2a
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Cat.#:IFNA2-1554HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human IFNA2, Active, His-tagged
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Cat.#:IFNA2-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His-tagged
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Cat.#:IFNA2-16HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2 protein
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Cat.#:IFNA2-170HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His/GST-tagged
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Cat.#:IFNA2-17HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, His-tagged
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Cat.#:IFNA2-189HTag:HSA
Source (Host):Pichia PastorisSpecies:Human
Product nameRecombinant Human IFNA2 Protein, HSA-tagged
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Cat.#:IFNA2-222HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNA2, StrepII-tagged
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Cat.#:IFNA2-24HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-29497THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-29498THTag:
Source (Host):Species:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-532HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-59HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2
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Cat.#:IFNA2-8514HTag:N-Human Albumin
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2, N-Human Albumin-tagged
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Cat.#:Ifna2-15MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifna2
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Cat.#:Ifna2-875MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ifna2 Protein
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Cat.#:Ifna2-88MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interferon Alpha 2
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Cat.#:Ifna2-89MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifna2, Fc tagged
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Cat.#:Ifna2-171RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ifna2 Protein, His-tagged
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Cat.#:IFNA2-72CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2, His tagged
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Cat.#:IFNA2-8830CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2, Fc tagged
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Cat.#:IFNA2-1192RTag:
Source (Host):YeastSpecies:Rhesus Macaque
Product nameRecombinant Rhesus IFNA2 Protein
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Cat.#:IFNA2-2204RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IFNA2 Protein, His-tagged
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Cat.#:IFNA2-548FTag:
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline IFNA2
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Cat.#:IFNA2-601PTag:
Source (Host):mammalian cellsSpecies:Porcine
Product nameRecombinant Porcine IFNA2
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Cat.#:IFNA2-139HTag:HQ
Source (Host):endosperm tissueSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, HQ-tagged
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Cat.#:IFNA2-117MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Interferon, Alpha 2
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Cat.#:IFNA2-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon-alpha 2a
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Cat.#:IFNA2-03HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon-alpha 2b
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Cat.#:INFA2-04HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human HSA-Interferon Alpha-2b
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Cat.#:IFNA2-009NTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, His-tagged
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Cat.#:IFNA2-1634MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IFNA2 cell lysate
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Cat.#:IFNA2-954CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2 cell lysate
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Cat.#:IFNA2-P008HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 therapeutic protein
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Involved Pathway

IFNA2 involved in several pathways and played different roles in them. We selected most pathways IFNA2 participated on our site, such as Cytokine-cytokine receptor interaction, Regulation of autophagy, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNA6; TNFSF13B; TGFBR1B; GH1; CCL6; CCL27; VEGFAB; TNFSF15; KIT; CXCR4
Regulation of autophagy
ATG14; ATG12; IFNA5; ULK1; IFNA12; GABARAPL2; PRKAA2; INS2; ULK2; ATG4B
PIK-Akt signaling pathway
Reln; ITGA4; IL2RA; PPP2R5E; MLST8; IL7; CREB3L3; ITGA7; PPP2CA; MET
Toll-like receptor signaling pathway
PIK3R1; MAP2K4; TLR5; TNF; IFNB1; IFNA12; LY96; TLR4BA; PIK3R5; STAT1
RIG-I-like receptor signaling pathway
RELA; RIPK1; MAPK12A; IFNA16; IL12A; NFKB1; NT5C3; IFNA14; MAPK12; IFNA7
Cytosolic DNA-sensing pathway
IFNPHI3; IFNA14; OSTN; IRF7; POLR3E; MB21D1; IFNA3; IL18; PYCARD; CCL4
Jak-STAT signaling pathway
IFNA6; HRAS; LEPB; IL29; GHRA; AKT2L; STAT4; PIAS4A; IL13RA2; HRASB
Natural killer cell mediated cytotoxicity
HCST; PLCG1; PTPN11; IFNGR1; NRAS; SH2D1A; TNF; TNFRSF10D; PPP3CA; NCR3
Tuberculosis
HLA-DMA; Cd209g; IRAK1; CLEC4M; PLK3; CALML5; RAB7A; LAMP2; Il23a; TLR2
Hepatitis C
TRAF3; IFIT1; CLDN2; MAPK11; CLDN11; ARAF; PIK3R5; IFNA21; KRAS; IFNA14
Hepatitis B
PIK3R3; CASP8; MAVS; IFNA12; GRB2; CYCS; CREB3L1; FOS; PIK3R2; STAT6
Measles
IFNA14; MX1; IRAK1; IL6; TNFRSF10A; HSPA8; IFNGR1; CCND1; EIF2AK1; CD3D
Influenza A
FASLG; IL-8; CXCL8; IL33; BLB1; PML; TNFRSF10C; HLA-DMA; AGFG1; TLR7
Herpes simplex infection
TAB2; NFKBIAA; ARNTL1A; MAPK8; MHC1UEA; RELA; C3A.1; PVRL2; FADD; TNFB
Autoi
HLA-DOB; HLA-DQA1; HLA-DPB1; IL4; IL5; TSHB; FASLG; HLA-E; IFNA8; H2-AB1
ne thyroid disease
HLA-DQB1; IFNA10; IFNA14; CD86; IFNA21; IFNA12; HLA-DRB1; HLA-DMA; H2-AB1; IL4

Protein Function

IFNA2 has several biochemical functions, for example, cytokine activity, protein binding, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA2 itself. We selected most functions IFNA2 had, and list some proteins which have the same functions with IFNA2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein HMGB1; TNFSF8; MSTN; GDF6; IFNA3; IL6; IL12BA; CCL4; TGFB2; CMTM1
Function protein binding
Related Protein MFF; KCTD14; OTUB2; ZP3; SMO; CD14; CSNK1D; ZNF643; SS18; PHB2
Function type I interferon receptor binding
Related Protein Ifna15; GM13279; IFNA14; IFNB1; IFNPHI3; IFNA13; IFNA7; IFNA16; IFNA4; IFNA3

Interacting Protein

IFNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNA2.
IFNAR2

IFNA2 Related Gene Family

Cytokines