ifna2
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  • Official Full Name
  • IFNA2 interferon, alpha 2
  • Background
  • Interferon alpha (IFN alpha) is a glycosylated protein which is produced by many cell types such as monocytes, macrophages, ?broblasts in response to virus infection, nucleic acid induction, glucocorticoid hormones. Some of the other biological effects, including antitumor and immunomodulatory activities IFN-alpha ’s most important function is the antiviral activity. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides. Some other biological processes involving IFN alpha are:induction of apoptosis, signal transduction, in?ammatory response. IFN alpha activates cytotoxic T-cells. IFN alpha binds to its receptors, which upon dimerisation, activate the JAK-STAT pathway.
  • Synonyms
  • IFNA2; interferon, alpha 2; interferon alpha-2; alpha 2a interferon; IFN alphaA; IFNA; interferon alpha 2b; interferon alpha A; leIF A; IFN-alpha-2; alpha-2a interferon; INFA2; IFNA2B; IFN-alphaA; MGC125764; MGC125765
Cat.#:IFNA2-1188HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNA2 Protein, MYC/DDK-tagged
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Cat.#:IFNA2-1555HTag:His
Source (Host):Nicotiana Sp.PlantSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His-tagged
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Cat.#:IFNA2-05HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pegylated Interferon Alpha-2b
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Cat.#:IFNA2-91HTag:N/A
Source (Host):PseudomonasputidaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2
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Cat.#:IFNA2-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pegylated Interferon Alpha-2a
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Cat.#:IFNA2-1554HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human IFNA2, Active, His-tagged
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Cat.#:IFNA2-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His-tagged
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Cat.#:IFNA2-16HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2 protein
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Cat.#:IFNA2-170HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His/GST-tagged
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Cat.#:IFNA2-17HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, His-tagged
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Cat.#:IFNA2-189HTag:HSA
Source (Host):Pichia PastorisSpecies:Human
Product nameRecombinant Human IFNA2 Protein, HSA-tagged
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Cat.#:IFNA2-222HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNA2, StrepII-tagged
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Cat.#:IFNA2-24HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-29497THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-29498THTag:
Source (Host):Species:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-532HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-59HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2
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Cat.#:IFNA2-8514HTag:N-Human Albumin
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2, N-Human Albumin-tagged
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Cat.#:Ifna2-15MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifna2
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Cat.#:Ifna2-875MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ifna2 Protein
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Cat.#:Ifna2-88MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interferon Alpha 2
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Cat.#:Ifna2-89MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifna2, Fc tagged
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Cat.#:Ifna2-171RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ifna2 Protein, His-tagged
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Cat.#:IFNA2-72CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2, His tagged
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Cat.#:IFNA2-8830CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2, Fc tagged
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Cat.#:IFNA2-1192RTag:
Source (Host):YeastSpecies:Rhesus Macaque
Product nameRecombinant Rhesus IFNA2 Protein
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Cat.#:IFNA2-2204RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IFNA2 Protein, His-tagged
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Cat.#:IFNA2-548FTag:
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline IFNA2
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Cat.#:IFNA2-601PTag:
Source (Host):mammalian cellsSpecies:Porcine
Product nameRecombinant Porcine IFNA2
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Cat.#:IFNA2-139HTag:HQ
Source (Host):endosperm tissueSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, HQ-tagged
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Cat.#:IFNA2-117MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Interferon, Alpha 2
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Cat.#:IFNA2-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon-alpha 2a
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Cat.#:IFNA2-03HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon-alpha 2b
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Cat.#:INFA2-04HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human HSA-Interferon Alpha-2b
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Cat.#:IFNA2-009NTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, His-tagged
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Cat.#:IFNA2-1634MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IFNA2 cell lysate
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Cat.#:IFNA2-954CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2 cell lysate
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Cat.#:IFNA2-P008HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 therapeutic protein
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Involved Pathway

IFNA2 involved in several pathways and played different roles in them. We selected most pathways IFNA2 participated on our site, such as Cytokine-cytokine receptor interaction, Regulation of autophagy, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR4; LTB; IFNW1; Il4ra; THPO; Il6ra; GM10591; TNFSF12; TNFRSF13B; IL8L1
Regulation of autophagy
GABARAPL2; IFNA14; ATG7; INS2; IFNA5; ATG10; IFNA21; BECN1; ATG4D; ATG14
PIK-Akt signaling pathway
FASLG; RPS6KB2; LAMA4; TCL1B1; TRP53; PPP2R5B; FGF18; FGF13; ITGA3; GNG7
Toll-like receptor signaling pathway
MAPK11; IFNA16; Ifna15; RELA; CXCL8B.3; TRAF6; NFKBIA; RAC1B; TLR8; TLR1LB
RIG-I-like receptor signaling pathway
Ifna15; MAPK14A; MAPK8B; NLRX1; TP-1; IFNB; IFNE; ATG12; IFNPHI1; NFKBIB
Cytosolic DNA-sensing pathway
IL1B; NFKBIAB; TREX1; CCL4L1; POLR3F; IFNA12; AIM2; LOC100033925; ADAR; IFNA1
Jak-STAT signaling pathway
PIK3R1; SOCS9; PRLRA; SOCS3; HRAS; STAT5B; PIK3CB; AKT3A; IFNAR1; IL11RA
Natural killer cell mediated cytotoxicity
KLRC3; IFNGR1; GRB2; GM-CSF; CD247; ULBP1; Casp3; NFATC1; MAP2K2; IFNGR2
Tuberculosis
IFNA4; CAMK2G; Cd209g; CALM1; MRC1; ITGB2; IFNA7; EEA1; CD14; HLA-DMB
Hepatitis C
OAS2; CLDN17; SCARB1; IFNAR2; EIF2AK3; SOCS3; TRADD; STAT2; PPP2R2A; EIF2AK1
Hepatitis B
TGFB2; TIRAP; APAF1; IKBKG; DDX58; MAVS; NFKBIA; PIK3R1; Casp3; RB1
Measles
CLEC4M; Fasl; CD209; OAS2; CD3G; TP73; TLR7; IL2RG; IRF7; IRAK4
Influenza A
HSPA8; HSPA1B; OAS1; CPSF4; RAF1; IFNA21; IFNA2; IL8L2; MAP2K7; TLR3
Herpes simplex infection
CD74A; HMGN1; C3A.2; DAXX; BLB2; UBE2R2; LOC100033925; CASP3A; IFNB1; TAB2
Autoi
IFNA8; HLA-DOB; IFNA16; IFNA21; IL5; Fasl; HLA-DQA2; IFNA6; HLA-DQA1; HLA-DOA
ne thyroid disease
HLA-F; HLA-G; IFNA10; IFNA14; HLA-DRB5; PRF1; IFNA8; HLA-DQA2; CD86; HLA-DQB1

Protein Function

IFNA2 has several biochemical functions, for example, cytokine activity, protein binding, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA2 itself. We selected most functions IFNA2 had, and list some proteins which have the same functions with IFNA2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GDF9; CLCF1; SCG2; IL36B; GPI; FLT3LG; GREM1; INHBE; INHBA; IFNA21
Function protein binding
Related Protein KIF5C; AGR2; MPP5; VARS2; FADD; LTF; PIFO; HDAC3; HIPK2; CD300A
Function type I interferon receptor binding
Related Protein IFNPHI1; IFNA16; IFNA3; IFNA4; IFNB; OSTN; IFNW1; GM13285; IFNPHI3; IFNE

Interacting Protein

IFNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNA2.
IFNAR2

IFNA2 Related Gene Family

Cytokines