ifna2
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  • Official Full Name
  • IFNA2 interferon, alpha 2
  • Background
  • Interferon alpha (IFN alpha) is a glycosylated protein which is produced by many cell types such as monocytes, macrophages, ?broblasts in response to virus infection, nucleic acid induction, glucocorticoid hormones. Some of the other biological effects, including antitumor and immunomodulatory activities IFN-alpha ’s most important function is the antiviral activity. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides. Some other biological processes involving IFN alpha are:induction of apoptosis, signal transduction, in?ammatory response. IFN alpha activates cytotoxic T-cells. IFN alpha binds to its receptors, which upon dimerisation, activate the JAK-STAT pathway.
  • Synonyms
  • IFNA2; interferon, alpha 2; interferon alpha-2; alpha 2a interferon; IFN alphaA; IFNA; interferon alpha 2b; interferon alpha A; leIF A; IFN-alpha-2; alpha-2a interferon; INFA2; IFNA2B; IFN-alphaA; MGC125764; MGC125765
Cat.#:IFNA2-1188HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNA2 Protein, MYC/DDK-tagged
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Cat.#:IFNA2-1555HTag:His
Source (Host):Nicotiana Sp.PlantSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His-tagged
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Cat.#:IFNA2-05HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pegylated Interferon Alpha-2b
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Cat.#:IFNA2-91HTag:N/A
Source (Host):PseudomonasputidaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2
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Cat.#:IFNA2-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pegylated Interferon Alpha-2a
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Cat.#:IFNA2-1554HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human IFNA2, Active, His-tagged
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Cat.#:IFNA2-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His-tagged
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Cat.#:IFNA2-16HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2 protein
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Cat.#:IFNA2-170HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 Protein, His/GST-tagged
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Cat.#:IFNA2-17HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, His-tagged
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Cat.#:IFNA2-189HTag:HSA
Source (Host):Pichia PastorisSpecies:Human
Product nameRecombinant Human IFNA2 Protein, HSA-tagged
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Cat.#:IFNA2-222HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNA2, StrepII-tagged
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Cat.#:IFNA2-24HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-29497THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-29498THTag:
Source (Host):Species:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-532HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2
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Cat.#:IFNA2-59HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2
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Cat.#:IFNA2-8514HTag:N-Human Albumin
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA2, N-Human Albumin-tagged
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Cat.#:Ifna2-15MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifna2
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Cat.#:Ifna2-875MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ifna2 Protein
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Cat.#:Ifna2-88MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interferon Alpha 2
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Cat.#:Ifna2-89MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifna2, Fc tagged
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Cat.#:Ifna2-171RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ifna2 Protein, His-tagged
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Cat.#:IFNA2-72CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2, His tagged
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Cat.#:IFNA2-8830CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2, Fc tagged
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Cat.#:IFNA2-1192RTag:
Source (Host):YeastSpecies:Rhesus Macaque
Product nameRecombinant Rhesus IFNA2 Protein
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Cat.#:IFNA2-2204RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IFNA2 Protein, His-tagged
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Cat.#:IFNA2-548FTag:
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline IFNA2
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Cat.#:IFNA2-601PTag:
Source (Host):mammalian cellsSpecies:Porcine
Product nameRecombinant Porcine IFNA2
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Cat.#:IFNA2-139HTag:HQ
Source (Host):endosperm tissueSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, HQ-tagged
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Cat.#:IFNA2-117MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Interferon, Alpha 2
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Cat.#:IFNA2-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon-alpha 2a
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Cat.#:IFNA2-03HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon-alpha 2b
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Cat.#:INFA2-04HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human HSA-Interferon Alpha-2b
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Cat.#:IFNA2-009NTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Interferon, Alpha 2, His-tagged
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Cat.#:IFNA2-1634MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IFNA2 cell lysate
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Cat.#:IFNA2-954CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNA2 cell lysate
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Cat.#:IFNA2-P008HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA2 therapeutic protein
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Involved Pathway

IFNA2 involved in several pathways and played different roles in them. We selected most pathways IFNA2 participated on our site, such as Cytokine-cytokine receptor interaction, Regulation of autophagy, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL19; IL5RA; VEGFC; ACVR1L; CXCL2; CXCL1; IFNA6; VEGFA; TP-1; IL11RA
Regulation of autophagy
PIK3C3; IFNA1; GABARAPL2; ULK3; IFNA5; PIK3R4; ATG10; IFNA2; ATG3; INS
PIK-Akt signaling pathway
IFNA13; ANGPT2; IFNA4; KRAS; G6PC2; FLT1; PRLR; MTOR; GSK3B; LAMC1
Toll-like receptor signaling pathway
IL8L2; MAPK12A; RAC1A; CCL3; TRAF3; LBP; TBK1; FOS; NFKB1; CXCL9
RIG-I-like receptor signaling pathway
IFNA16; IFNA6; RIPK1; ISG15; IFNA17; MAPK12; TBK1; RELA; NFKB1; IFNA12
Cytosolic DNA-sensing pathway
IFNA3; IFNA17; CASP1; IL18; IKBKG; IFN-a; POLR2F; IFNA10; IL1B; IL6
Jak-STAT signaling pathway
PRLR; BCL2L1; EPOR; IL6ST; IFNA7; IL28RA; LIFRA; Ifna15; GRB2; IL24
Natural killer cell mediated cytotoxicity
TNFRSF10A; IFNA16; PIK3CD; LCP2; RAET1D; ICAM2; IFNA8; ICAM1; IFNG; KLRC2
Tuberculosis
CALM4; MAPK13; CEBPG; CLEC7A; IRAK2; CARD9; BAX; RFXANK; IL12A; HLA-DQB1
Hepatitis C
TRAF6; CLDN14; MAVS; Ifna15; CLDN4; TNFRSF1A; MAPK12; IRF9; MAPK9; CLDN18
Hepatitis B
APAF1; MAVS; CASP8; TIRAP; TGFB1; RAF1; OSTN; MAP2K4; PIK3CD; TGFB2
Measles
IL1B; NFKBIA; IFNA5; TNFRSF10B; TAB2; MSN; CD3G; RCHY1; IFNGR1; IL12B
Influenza A
PIK3R2; HLA-DMA; EIF2AK1; NXF1; HLA-DOB; DNAJB1; EP300; BLA; XPO1; RNASEL
Herpes simplex infection
HLA-DPA1; LTA; H2-Q10; IFNG; EIF2AK1; CDC34; MYD88; IFNGR1; MHC2DEB; PVRL2
Autoi
CD28; IFNA17; HLA-DQB1; TPO; IFNA8; HLA-DMA; CD80; Ifna15; IFNA7; IFNA4
ne thyroid disease
Il2; IFNA2; FAS; IFNA5; Fasl; HLA-DQA1; HLA-DQB1; HLA-E; HLA-C; HLA-DPB1

Protein Function

IFNA2 has several biochemical functions, for example, cytokine activity, protein binding, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA2 itself. We selected most functions IFNA2 had, and list some proteins which have the same functions with IFNA2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein BMP7B; IFNA21; CSF3; GM13285; IL37; CSF1A; CSF1B; SLURP1; IFNA13; IL22
Function protein binding
Related Protein MEIOB; FSHR; EXOC8; TNNC2; TTR; USP36; CDC25B; ACE; DPYD; OAS1
Function type I interferon receptor binding
Related Protein IFNW1; IFNK; GM13278; IFNA3; IFNA17; IFNA10; IFNA13; IFNE; GM13285; IFNA21

Interacting Protein

IFNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNA2.
IFNAR2

IFNA2 Related Gene Family

Cytokines