il5ra
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  • Official Full Name
  • interleukin 5 receptor, alpha
  • Background
  • Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.
    The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms
  • IL5RA; interleukin 5 receptor, alpha; IL5R; interleukin-5 receptor subunit alpha; CD125; CDw125; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; HSIL5R3; MGC26560
Cat.#:IL5RA-2094HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5RA Protein, MYC/DDK-tagged
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Cat.#:IL5RA-5176HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL5RA Protein
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Cat.#:IL5RA-125HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5RA Protein, His-tagged
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Cat.#:IL5RA-126HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 5 receptor, Alpha, 308aa, Fc Chimera
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Cat.#:IL5RA-127HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 5 Receptor, Alpha, 322aa, Fc Chimera
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Cat.#:IL5RA-1646HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Interleukin 5 Receptor, Alpha
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Cat.#:IL5RA-27608THTag:
Source (Host):Species:Human
Product nameRecombinant Human IL5RA
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Cat.#:IL5RA-28136THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human IL5RA, Fc-tagged
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Cat.#:IL5RA-3834HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5RA, His tagged
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Cat.#:IL5RA-45HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL5RA protein, His-tagged
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Cat.#:IL5Ra-431MTag:FC/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Il5ra, His tagged
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Cat.#:Il5ra-5663MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 5 Receptor, Alpha, Fc-tagged
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Cat.#:Il5ra-64MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Il5ra Protein, His-tagged
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Cat.#:Il5ra-7064MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il5ra protein, His & T7-tagged
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Cat.#:IL5RA-620CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL5RA Protein, His-tagged
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Cat.#:IL5RA-4581CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL5RA
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Cat.#:IL5RA-2060HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5RA cell lysate
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Cat.#:IL5RA-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse IL5RA cell lysate
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Involved Pathway

IL5RA involved in several pathways and played different roles in them. We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL5RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
XCL1; IFNA5; IL15RA; IL4; RNF207B; ACVR1L; IL28A; TGFBR1B; IL10RA; Flt3l
Jak-STAT signaling pathway
IFNPHI1; PIAS2; OSM; RAF1A; EPOR; GM-CSF; AOX2P; IL22; IL15; IFNPHI3
Hematopoietic cell lineage
IL2RA; CD1D2; FLT3; ITGA1; Fcer2a; CSF1; GYPA; GP1BA; TFRC; KIT

Protein Function

IL5RA has several biochemical functions, for example, interleukin-5 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL5RA itself. We selected most functions IL5RA had, and list some proteins which have the same functions with IL5RA. You can find most of the proteins on our site.
Function
Related Protein
Function interleukin-5 receptor activity
Related Protein IL5RA
Function protein binding
Related Protein PGM2; PPFIA2; HEMK1; ORAI3; TMEM140; TIMELESS; KIAA0649; KCNMA1; PMM1; CCPG1

Interacting Protein

IL5RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL5RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL5RA.
IL5; CSF2RB; GRB2

IL5RA Related Articles

Losol, P; Kim, SH; et al. A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease. EXPERIMENTAL AND MOLECULAR MEDICINE 45:-(2013).

IL5RA Related Gene Family

IL