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Recombinant Human Interleukin 5 receptor, Alpha, 308aa, Fc Chimera

Cat.No. : IL5RA-126H
Product Overview : Recombinant Human interleukin 5 receptor, alpha encoding the signal peptide and extracellular domain of human Interleukin 5 receptor alpha chain (aa 1-327) was expressed in modifiedhuman 293 cells. It was fused to the Fc region of human IgG1 (aa 93-330).
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Cat. No. : IL5RA-126H
Description : Interleukin 5 (IL-5) plays an important role in B cell development by inducing the terminal differentiation of late-developing B cells. Additionally, IL-5 regulates the differentiation, survival and degranulation of eosinophils. IL-5 is expressed predominately by T-lymphocytes and mast cells, and to a lesser extent by eosinophils, natural killer cells and endothelial cells.
Source : Human 293 cells.
Amino Acid Sequence : DLLPDEKISLLPPVNF TIKVTGLAQVLL QWKP NPDQ EQRN VNLEYQVKIN APKEDDYET RITES KCVTIL HKGFSASVRTILQNDHSLLASSWASA EL HAPPGSPG TSIVNLTCTTN T TEDNYSRLRSY QVSLHCTWLVG TDAPEDTQYFL YYR YGS WTEEC QEYSKDTLGRN IACWFPRTFILS KG RD WLAVLV NGSSKHSAIRP FDQL FAL HAID QINPP LNVTA EIEGTRLSIQW EKPVSAFPIHC FDY EVKIHNTR NGYL QIEKLMT NAFISIIDDLSKY DVQVRAAV SSMCREAG LWSEWSQ RIPKVDKKV EP KSCDKT HTCPPCPA PELLGGPS VFLFPPKP KDTLMISRTPE VTCVVVD VS HEDPE VK FNWYV DGVEVHN AKTKPREEQYNST YRVVSVLT VLHQDWL NG KE YKCRVSNKALPAPI EK TIS KA K GQPREPQ VYTLPPSR DELT KNQ VSLTC LVK GFYPSD IAVEWESNG QPENNYK TTP PVL DS DGS FFLY SKLT VDK SRW QQG NVFSCSVMHEALHNHYTQKSLSLSPGK.
Molecular Mass : Under reducing conditions IL-5R alpha (308aa)-Fc Chimera migrates as a broad band between 70 and 80 kDa on SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-5R alpha (308aa)-Fc Chimera that has a predicted monomeric molecular mass of 62.1 kDa.
PI : IL-5R alpha (308aa)-Fc Chimeraseparates into a number of glycoforms with a pI between 5.8 and 7.0 on 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-5R alpha (308aa)-Fc Chimera that has a predicted pI of 6.34.
% Carbohydrate : Purified IL-5R alpha (308aa)-Fc Chimera consists of 10-25% carbohydrate by weight.
Glycosylation : IL-5R alpha (308aa)-Fc Chimerahas N-linked and O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name : IL5RA interleukin 5 receptor, alpha [ Homo sapiens ]
Synonyms : IL5RA; interleukin 5 receptor, alpha; CD125; CDw125; HSIL5R3; IL5R; MGC26560; CD125 antigen; OTTHUMP00000115373; OTTHUMP00000206893; OTTHUMP00000206896; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; interleukin-5 receptor alpha subunit; OTTHUMP00000115257; IL-5R-alpha
Gene ID : 3568
mRNA Refseq : NM_000564
Protein Refseq : NP_000555
MIM : 147851
UniProt ID : Q01344
Chromosome Location : 3p26-p24
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage
Function : interleukin-5 receptor activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the clinical applications of IL5RA? 10/20/2022

Recombinant IL5RA can be used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. It can reduce the frequency and severity of asthma attacks by blocking the signaling of interleukin 5.

Can recombinant IL5RA be used to treat other diseases? 06/03/2022

Currently, recombinant IL5RA is mainly used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. For other diseases, the suitability of IL5RA is subject to further research and clinical trials.

Does the use of IL5RA require blood routine examination? 12/10/2020

During the use of IL5RA, the doctor may ask to check the patient's blood routine regularly to monitor changes in blood counts and related indicators. This helps to evaluate the efficacy of the treatment and the safety of the patient.

Does IL5RA cause dependence? 10/26/2019

There is no clear evidence that long-term use of recombinant IL5RA causes dependence. For patients using IL5RA, it is best to treat and discontinue the drug according to the advice and guidance of their doctor.

What is the use of IL5RA? 10/22/2019

IL5RA is generally administered by subcutaneous injection. The specific use method and dosage should be determined according to the doctor's recommendation and the specific situation of the patient.

What are the side effects of IL5RA? 06/18/2019

Common side effects of recombinant IL5RA include pain at the injection site, redness and swelling at the injection site, cough, and sore throat. A small number of patients may experience allergic reactions or serious adverse reactions, so close monitoring of the patient's condition and signs is required when using.

Customer Reviews (3)

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Reviews
04/05/2021

    Good stability under different temperature and humidity conditions.

    03/27/2021

      In the process of purification, the removal of impurities is good.

      11/13/2020

        Chemical modifications, such as PEGylation or glycosylation, have little effect.

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