Recombinant Mouse Il5ra Protein, MYC/DDK-tagged

• Cat.No.: Il5ra-1245M
• Product Overview: Purified recombinant protein of full-length mouse interleukin 5 receptor, alpha (Il5ra), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This is the receptor for interleukin-5. The alpha chain binds to IL5.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 47.4 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Il5ra interleukin 5 receptor, alpha [ Mus musculus (house mouse) ]
• Official Symbol: Il5ra
• Synonyms: Il5ra; interleukin 5 receptor, alpha; Il5r; CD125; CDw125; interleukin-5 receptor subunit alpha; IL-5 receptor alpha chain; IL-5 receptor subunit alpha; IL-5R subunit alpha
• Gene ID: 16192
• mRNA Refseq: NM_008370
• Protein Refseq: NP_032396
• UniProt ID: P21183

Reviews

04/05/2021

Good stability under different temperature and humidity conditions.

03/27/2021

In the process of purification, the removal of impurities is good.

11/13/2020

Chemical modifications, such as PEGylation or glycosylation, have little effect.

Q&As

What are the clinical applications of IL5RA?

Recombinant IL5RA can be used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. It can reduce the frequency and severity of asthma attacks by blocking the signaling of interleukin 5.

Can recombinant IL5RA be used to treat other diseases?

Currently, recombinant IL5RA is mainly used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. For other diseases, the suitability of IL5RA is subject to further research and clinical trials.

Does the use of IL5RA require blood routine examination?

During the use of IL5RA, the doctor may ask to check the patient's blood routine regularly to monitor changes in blood counts and related indicators. This helps to evaluate the efficacy of the treatment and the safety of the patient.

Does IL5RA cause dependence?

There is no clear evidence that long-term use of recombinant IL5RA causes dependence. For patients using IL5RA, it is best to treat and discontinue the drug according to the advice and guidance of their doctor.

What is the use of IL5RA?

IL5RA is generally administered by subcutaneous injection. The specific use method and dosage should be determined according to the doctor's recommendation and the specific situation of the patient.

What are the side effects of IL5RA?

Common side effects of recombinant IL5RA include pain at the injection site, redness and swelling at the injection site, cough, and sore throat. A small number of patients may experience allergic reactions or serious adverse reactions, so close monitoring of the patient's condition and signs is required when using.