insr
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  • Official Full Name
  • Insulin Receptor
  • Background
  • This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
  • Synonyms
  • CD220; CD220 antigen; HHF 5; INSR; INSR_HUMAN; Insulin receptor subunit beta; IR; Insulin Receptor
Cat.#:INSR-497HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR Protein (Long Isoform) (Met1-Lys956), His-tagged, Biotinylated
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Cat.#:INSR-1260HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSR Protein, His-SUMO-tagged
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Cat.#:INSR-5092HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INSR Protein, GST-tagged
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Cat.#:INSR-5093HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human INSR Protein, GST-tagged
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Cat.#:INSR-216HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR protein, DDK/His-tagged
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Cat.#:INSR-27625THTag:
Source (Host):Species:Human
Product nameRecombinant Human INSR
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Cat.#:INSR-29493THTag:
Source (Host):Species:Human
Product nameRecombinant Human INSR
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Cat.#:INSR-294HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human INSR Protein, His & GST-tagged
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Cat.#:INSR-331HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Insulin Receptor, GST-tagged, Active
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Cat.#:INSR-611HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Insulin Receptor, Fc Chimera
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Cat.#:INSR-622HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR, His tagged
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Cat.#:INSR-623HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR, His tagged
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Cat.#:INSR-661HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human INSR, His-tagged
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Cat.#:INSR-7893HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSR protein, His-tagged
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Cat.#:INSR-7894HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSR protein, His-tagged
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Cat.#:Insr-7895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Insr protein, His-tagged
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Cat.#:INSR-8242MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INSR Protein
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Cat.#:Insr-7896RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Insr protein, His-tagged
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Cat.#:INSR-1604RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey INSR Protein
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Cat.#:INSR-1605RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey INSR Protein, hIgG1-tagged
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Cat.#:INSR-1606RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey INSR Protein, hIgG4-tagged
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Cat.#:INSR-1416HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human InsR (Active), GST-tagged
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Cat.#:INSR-2648HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR cell lysate
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Cat.#:INSR-474HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human INSR cell lysate
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Cat.#:Kit-1605Tag:
Source (Host):Species:
Product nameU2OS INSR Bioassay Kit
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Cat.#:Kit-1607Tag:
Source (Host):Species:
Product nameINSR Internalization Assay Kit
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Involved Pathway

INSR involved in several pathways and played different roles in them. We selected most pathways INSR participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RAP1A; PTPN11; FGF1; GNG11; PAK3; FGF16; FLT1; CALM2; PLA2G12A; RAC1
Rap signaling pathway
PRKCB; GRIN1; RAP1B; ITGAL; ITGB1; FGF10; INS; VEGFB; VASP; INSR
cGMP-PKG signaling pathway
GNAI1; MYH7; NFATC3; IRS2; CALML5; AKT1; KCNMB3; PRKG2; SLC25A6; NFATC2
HIF- signaling pathway
GAPDH; TCEB2; EP300; ENO1; PRKCB; LTBR; CAMK2G; PIK3CB; NFKB1; IFNG
FoxO signaling pathway
S1PR1; NRAS; PRKAG1; SGK3; AKT2; CAT; MAPK8B; GRB2; SGK1; PDPK1
Phospholipase D signaling pathway
PLCB3; GRM1; DGKD; GRB2; GRM6; Adcy4; RRAS2; FCER1A; PLA2G4D; GAB1
PIK-Akt signaling pathway
GNB1; PIK3R2; Pdgfa&Pdgfb; ITGA1; KRAS; SGK1; STK11; G6PC3; GNB2; GRB2
AMPK signaling pathway
SLC2A4; CCND1; FBP1; FASN; PFKL; EEF2; PFKM; TSC1; MTOR; RAB10
Adherens junction
FGFR1A; Fert2; CTNNA1; RAC3B; CTNND1; ACTB1; PTPN1; TGFBR2; CSNK2A2; ACTB2
Insulin signaling pathway
G6PCA.1; SHC1; MAPK10; PHKG1A; INS2; FBP2; HK2; RAPGEF1; PIK3R3; GRB2
Ovarian steroidogenesis
GDF9; FSHB; CYP2J5; BMP15; Adcy4; PLA2G4A; ACOT2; PTGS2; IGF1R; HSD3B6
Regulation of lipolysis in adipocytes
PTGS1; GNAI1; NPY; PRKACA; PIK3R2; PRKACG; PRKACB; PDE3B; PIK3CD; INS2
Type II diabetes mellitus
ADIPOQ; MAPK1; PIK3CB; TNF; INS1; PIK3R5; HK2; SOCS3; PIK3CA; PKM2
Insulin resistance
CREB3L3A; TNFRSF1A; PIK3CA; PRKCQ; PRKAB1B; IL6; NFKBIAB; PPP1CAA; OGT.1; CREB5
Non-alcoholic fatty liver disease (NAFLD)
NDUFA9; COX7A2; Casp3; TNFRSF1A; PRKAG2; GSK3A; MAP3K11; NDUFA2; COX4I2; CDC42
Aldosterone-regulated sodium reabsorption
INS1; ATP1B1; ATP1B3; PIK3CB; MAPK3; MAPK1; PDPK1; PIK3R5; INS; NR3C2

Protein Function

INSR has several biochemical functions, for example, ATP binding, GTP binding, PTB domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSR itself. We selected most functions INSR had, and list some proteins which have the same functions with INSR. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCC2; PDK4; CAMK1D; MAT2AB; Abca2; NME2; HELZ2; ACVR1; LATS1; TNIK
Function GTP binding
Related Protein RHOF; RHOAA; SEPT7A; RAB44; RSG1; ARL8BA; GBP1; RAB25B; GIMAP3; EEF1A2
Function PTB domain binding
Related Protein INPP5D; APP; INSR; NUP62
Function insulin binding
Related Protein PIK3R1; IDE; INSR; C2CD2L; IGF1R; HSPD1
Function insulin receptor substrate binding
Related Protein PIK3CB; PRKCD; GRB2; PIK3R1; PRKCZ; IGF1R; IGF1RB; JAK2; INSRR; PTPN11
Function insulin-activated receptor activity
Related Protein INSR
Function insulin-like growth factor I binding
Related Protein IGFBP2B; IGFBP5B; IGFBP1A; IGFBP2; IGFBP6B; IGFBP4; IGFBP3; INSR; IGFBP5; IGFBP1B
Function insulin-like growth factor II binding
Related Protein INSR; IGFBP5; IGFBP1B; IGFBP5A; IGFBP6; IGFBP2; IGFBP3; IGFBP2A; IGFBP2B; IGFBP5B
Function insulin-like growth factor receptor binding
Related Protein IGF2A; YWHAG; INSR; Ren1; IRS1; INS2; INSL4; PIK3R1; REN; SOCS2
Function phosphatidylinositol 3-kinase binding
Related Protein JAK2; FLT3; INSR; FYN; PDGFRB; INSRA; INSRB; IGF1RA; IGF1R; IRS1
Function protein binding
Related Protein WWOX; MAK; SIGLEC8; SIRT2; C10orf46; ING5; STAT6; DRAP1; CD244; PGR
Function protein tyrosine kinase activity
Related Protein EPHB4B; ABL2; KIT; MAP2K1; MAP2K2; IGF1R; NEK1; EPHA4A; MUSK; ERBB3A
Function receptor signaling protein tyrosine kinase activity
Related Protein ERBB3B; ERBB4A; EGFRA; INSR; TYRO3; LYN; KIT; KITA; EGFR; ERBB2

Interacting Protein

INSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSR here. Most of them are supplied by our site. Hope this information will be useful for your research of INSR.
PTPN1

INSR Related Articles

Besic, V; Shi, HJ; et al. Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery. PLOS ONE 10:-(2015).
McAllister, JM; Legro, RS; et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. TRENDS IN ENDOCRINOLOGY AND METABOLISM 26:118-124(2015).