insr
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  • Official Full Name
  • Insulin Receptor
  • Background
  • This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
  • Synonyms
  • CD220; CD220 antigen; HHF 5; INSR; INSR_HUMAN; Insulin receptor subunit beta; IR; Insulin Receptor
Cat.#:INSR-497HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR Protein (Long Isoform) (Met1-Lys956), His-tagged, Biotinylated
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Cat.#:INSR-1260HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSR Protein, His-SUMO-tagged
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Cat.#:INSR-5092HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INSR Protein, GST-tagged
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Cat.#:INSR-5093HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human INSR Protein, GST-tagged
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Cat.#:INSR-216HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR protein, DDK/His-tagged
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Cat.#:INSR-27625THTag:
Source (Host):Species:Human
Product nameRecombinant Human INSR
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Cat.#:INSR-29493THTag:
Source (Host):Species:Human
Product nameRecombinant Human INSR
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Cat.#:INSR-294HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human INSR Protein, His & GST-tagged
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Cat.#:INSR-331HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Insulin Receptor, GST-tagged, Active
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Cat.#:INSR-611HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Insulin Receptor, Fc Chimera
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Cat.#:INSR-622HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR, His tagged
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Cat.#:INSR-623HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR, His tagged
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Cat.#:INSR-661HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human INSR, His-tagged
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Cat.#:INSR-7893HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSR protein, His-tagged
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Cat.#:INSR-7894HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSR protein, His-tagged
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Cat.#:Insr-7895MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Insr protein, His-tagged
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Cat.#:INSR-8242MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INSR Protein
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Cat.#:Insr-7896RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Insr protein, His-tagged
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Cat.#:INSR-1604RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey INSR Protein
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Cat.#:INSR-1605RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey INSR Protein, hIgG1-tagged
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Cat.#:INSR-1606RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey INSR Protein, hIgG4-tagged
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Cat.#:INSR-1416HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human InsR (Active), GST-tagged
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Cat.#:INSR-2648HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human INSR cell lysate
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Cat.#:INSR-474HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human INSR cell lysate
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Cat.#:Kit-1605Tag:
Source (Host):Species:
Product nameU2OS INSR Bioassay Kit
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Cat.#:Kit-1607Tag:
Source (Host):Species:
Product nameINSR Internalization Assay Kit
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Involved Pathway

INSR involved in several pathways and played different roles in them. We selected most pathways INSR participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
MAPK1; PLA2G12A; PIK3CA; FLT1; ANGPT2; PLA2G4A; PLA2G4F; RAB5C; GNG5; KITLG
Rap signaling pathway
ITGB3; PDGFA; ITGAM; PLCB2; CALML3; LPAR3; PARD6B; FLT4; MAPK1; PFN1
cGMP-PKG signaling pathway
GNAI2; MAP2K1; NFATC1; CALM2; SLC8A2; ATP1A4; IRS1; MAP2K2; PRKG2; ATP1B3
HIF- signaling pathway
IL6; HKDC1; PRKCA; RPS6KB2; TF; AKT1; IFNGR2; EPO; PIK3CG; HK1
FoxO signaling pathway
FOXO3A; PRKAB1B; PIK3R3; MAPK8B; PRKAG3; BCL6A; STAT3; MAP2K2A; AKT2; EGFRA
Phospholipase D signaling pathway
PLCB3; DGKE; PIK3R1; CXCR2; GRM3; AGPAT5; CYTH3; SYK; AGPAT3; GRM6
PIK-Akt signaling pathway
INS2; LAMB1; PPP2R2D; NFKB1; TLR2; IBSP; ITGB8; ITGA2B; ATF4; Il2
AMPK signaling pathway
PPP2R3C; PFKFB2; RPS6KB1; GYS1; PRKAB1; RAB8A; LEPR; PFKP; RPS6KB2; PFKL
Adherens junction
MAP3K7; EP300; YES1; ACTB; RAC1A; NLK; TCF7L1A; TGFBR1A; CDC42L2; ACTN3
Insulin signaling pathway
MAPK9; HRAS; PRKAR1A; RAPGEF1; CALM4; MAP2K2; FOXO1A; RPTOR; HK3; FLOT1
Ovarian steroidogenesis
IGF1R; GDF9; HSD3B1; LDLR; IGF1; Adcy4; PLA2G4D; PLA2G4C; HSD3B2; PLA2G4F
Regulation of lipolysis in adipocytes
NPY; PTGS1; INS; PIK3R3; PNPLA2; PRKACG; LOC100328615; INS2; GNAI1; PIK3CG
Type II diabetes mellitus
MAPK9; HK1; PRKCE; MAPK3; PDX1; INSR; SOCS1; PIK3R1; CACNA1G; MAPK8
Insulin resistance
RPS6KA1; MGEA5; G6PC; PRKAG2; SLC27A1A; SLC2A2; STAT3; RPS6KA3B; G6PCA.1; GFPT1
Non-alcoholic fatty liver disease (NAFLD)
PRKAG2; NDUFA5; NDUFAB1; NDUFC2; NDUFA4L2; NDUFV3; NDUFS4; GSK3B; UQCRH; NDUFA8
Aldosterone-regulated sodium reabsorption
INS; PDPK1; ATP1B4; ATP1B2; INS2; PIK3CD; KCNJ1; ATP1A1; MAPK3; SCNN1B

Protein Function

INSR has several biochemical functions, for example, ATP binding, GTP binding, PTB domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSR itself. We selected most functions INSR had, and list some proteins which have the same functions with INSR. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CSF1RA; MYO1E; SMYHC1; ATM; MAP2K4B; MYH6; ATP1A4; TAE1; PHKG1; KDRL
Function GTP binding
Related Protein EIF2S3; RAB11B; GFM2; EEF2B; DIRAS2; RAB40AL; NPR1; ARL4C; ERCC3; RAB1B
Function PTB domain binding
Related Protein NUP62; INSR; APP; INPP5D
Function insulin binding
Related Protein IDE; C2CD2L; INSR; HSPD1; IGF1R; PIK3R1
Function insulin receptor substrate binding
Related Protein IGF1RB; INSR; INSRA; PRKCZ; PTPN11; INSRB; IGF1R; PIK3R1; IGF1RA; JAK2
Function insulin-activated receptor activity
Related Protein INSR
Function insulin-like growth factor I binding
Related Protein IGFBP1B; IGFBP2A; IGFBP2B; IGFBP6B; IGFBP5B; IGFBP2; INSR; IGFBP5; IGFBP5A; IGFBP4
Function insulin-like growth factor II binding
Related Protein IGFBP6; IGFBP2B; IGFBP2; IGFBP5A; IGFBP6B; IGFBP2A; INSR; IGFBP5; IGFBP6A; IGFBP1B
Function insulin-like growth factor receptor binding
Related Protein PIK3R1; IRS1; YWHAG; REN; IGF3; SHC1; IGF2A; YWHAH; INS; Ren1
Function phosphatidylinositol 3-kinase binding
Related Protein BECN1; LCK; INSR; CALM3; CALM1; CORO1A; INSRA; DAB1; JAK2; ATP1A1
Function protein binding
Related Protein CNPY2; TH; SGTA; FLOT1; HNRNPM; TIMM50; TRIM38; FBXW7; VPS45; CD209
Function protein tyrosine kinase activity
Related Protein NTRK2B; MAP3K9; DYRK1A; KDRL; PTK7A; FGFR3; ERBB3B; ABL1; IGF1RA; EPHB3A
Function receptor signaling protein tyrosine kinase activity
Related Protein EGFRA; ERBB4; KITB; TYRO3; EGFR; KIT; KITA; INSR; SYK; ERBB4A

Interacting Protein

INSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSR here. Most of them are supplied by our site. Hope this information will be useful for your research of INSR.
PTPN1

INSR Related Articles

Besic, V; Shi, HJ; et al. Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery. PLOS ONE 10:-(2015).
McAllister, JM; Legro, RS; et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. TRENDS IN ENDOCRINOLOGY AND METABOLISM 26:118-124(2015).