irak4
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  • Official Full Name
  • interleukin-1 receptor-associated kinase 4
  • Background
  • IRAK-4 is a member of the interleukin-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and crossphosphorylation kinase activity (4).
  • Synonyms
  • IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64
Cat.#:IRAK4-2438HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IRAK4 Protein, MYC/DDK-tagged
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Cat.#:IRAK4-5049HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRAK4 Protein, GST-tagged
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Cat.#:IRAK4-5437HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged
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Cat.#:IRAK4-26999THTag:GST
Source (Host):Species:Human
Product nameRecombinant Human IRAK4, GST-tagged
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Cat.#:IRAK4-27000THTag:
Source (Host):Species:Human
Product nameRecombinant Human IRAK4
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Cat.#:IRAK4-333HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IRAK4, GST-tagged, Active
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Cat.#:IRAK4-46HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IRAK4 protein, His-tagged
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Cat.#:IRAK4-54HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IRAK4 protein, Flag-tagged, Biotinylated
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Cat.#:IRAK4-7074HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRAK4 protein, His-tagged
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Cat.#:IRAK4-976HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IRAK4, His & GST tagged
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Cat.#:IRAK4-8295MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRAK4 Protein
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Cat.#:IRAK4-2291RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRAK4 Protein, His-tagged
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Cat.#:IRAK4-2439CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRAK4
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Cat.#:IRAK4-10510ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRAK4
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Cat.#:IRAK4-1418HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IRAK4 (Active), GST-tagged
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Cat.#:IRAK4-615HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IRAK4 cell lysate
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Involved Pathway

IRAK4 involved in several pathways and played different roles in them. We selected most pathways IRAK4 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
MYD88; BIRC3; GM13304; BLNK; CXCL2; ZAP70; NFKB2; RELA; IL1B; CCL21
Apoptosis
NGF; TRP53; AIFM1; DSG1; GZMC; PIK3R3; BADB; Fasl; BCL2L11; GZME
Toll-like receptor signaling pathway
PIK3R3; IRF7; MAPK13; CXCL10; TLR5; CCL4; RELA; LY96; RIPK1L; TLR2-2
Neurotrophin signaling pathway
MAPKAPK2; MAP2K7; BDNF; CAMK2A; NTRK1; MAPK3; NFKB1; PIK3R2; MAP3K1; PIK3CB
Pertussis
CALML5; NFKB1; NLRP3; SERPING1; CALM2; FOS; IRF8; ITGA5; ITGB2; CALM1
Leishmaniasis
IFNGR2; NCF1; ITGB1; HLA-DPB1; FOS; MYD88; ITGA4; ELK1; NOS2; HLA-DRA
Chagas disease (American trypanosomiasis)
TLR4; NFKBIA; IRAK1; PPP2CA; IFNG; TLR2; IL12A; GNA14; PIK3CA; MAP2K4
Toxoplasmosis
STAT3; IRAK1; XIAP; Casp3; MAPK1; LAMC2; IKBKB; TGFB2; BIRC3; HLA-DMB
Tuberculosis
RELA; NFYB; Casp3; IL12B; ITGAM; LBP; RAB5C; PIK3C3; FCGR3A; CLEC4E
Measles
TNFRSF10B; TNFAIP3; IL2RG; TNFRSF10C; NFKBIA; TNFRSF10A; HSPA8; CCND2; IKBKE; TLR2
Influenza A
VDAC1; TMPRSS13; H2-AB1; CPSF4; Ccl12; PLG; FURIN; CXCL10; RAF1; FAS

Protein Function

IRAK4 has several biochemical functions, for example, ATP binding, interleukin-1 receptor binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK4 itself. We selected most functions IRAK4 had, and list some proteins which have the same functions with IRAK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYH9A; PSMC5; NEK9; P2RX1; HSPA1B; PAPSS2A; STK39; NLRP9B; CCT5; GSS
Function interleukin-1 receptor binding
Related Protein Il1f6; TLR9; IL37; TLR5; IL36G; IRAK1; IL36A; IRAK4; IL1F10; IL1A
Function magnesium ion binding
Related Protein PCK1; CLYBL; RPS6KA4; HPRT1L; PRKACB; NT5C3L; ATP8B1; IDH2; MTPAP; ARF1
Function protein binding
Related Protein TXNDC12; CADPS; ISYNA1; CRBN; PICK1; IMPDH2; TGM2; ICAM5; RET; SGOL1
Function protein kinase activity
Related Protein NPR2; NTRK2B; ERBB3A; RPS6KAL; PAK2A; NAT1; Aatk; CDC42BPB; CSNK1DB; STK38A
Function protein serine/threonine kinase activity
Related Protein CDK16; TGFBR1B; PRKCHA; MOK; STK33; CDK5; SMOK3B; SLKA; MAPK8; CSNK1G2A

Interacting Protein

IRAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK4.
PELI2; IRAK1; TIRAP; PELI1; TNFRSF13B; IL1RL1; Irak3; ARNT; TBPL1; MYD88; IRAK2; KIF11

IRAK4 Related Articles

Cushing, L; Stochaj, W; et al. Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10865-10875(2014).
Jang, SE; Hyam, SR; et al. Penta-O-galloyl-beta-D-glucose ameliorates inflammation by inhibiting MyD88/NF-kappa B and MyD88/MAPK signalling pathways. BRITISH JOURNAL OF PHARMACOLOGY 170:1078-1091(2013).