Recombinant Human IRAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | IRAK4-058H |
Product Overview : | IRAK4 MS Standard C13 and N15-labeled recombinant protein (NP_057207) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 51.5 kDa |
AA Sequence : | MNKPITPSTYVRCLNVGLIRKLSDF IDPQEGWKKLAVAIKKPSGDDRYNQ FHIRRFEALLQTGKSPTSELLFDWG TTNCTVGDLVDLLIQNEFFAPASLL LPDAVPKTANTLPSKEAITVQQKQM PFCDKDRTLMTPVQNLEQSYMPPDS SSPENKSLEVSDTRFHSFSFYELKN VTNNFDERPISVGGNKMGEGGFGVV YKGYVNNTTVAVKKLAAMVDITTEE LKQQFDQEIKVMAKCQHENLVELLG FSSDGDDLCLVYVYMPNGSLLDRLS CLDGTPPLSWHMRCKIAQGAANGIN FLHENHHIHRDIKSANILLDEAFTA KISDFGLARASEKFAQTVMTSRIVG TTAYMAPEALRGEITPKSDIYSFGV VLLEIITGLPAVDEHREPQLLLDIK EEIEDEEKTIEDYIDKKMNDADSTS VEAMYSVASQCLHEKKNKRPDIKKV QQLLQEMTASTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | IRAK4 interleukin 1 receptor associated kinase 4 [ Homo sapiens (human) ] |
Official Symbol : | IRAK4 |
Synonyms : | IRAK4; interleukin 1 receptor associated kinase 4; IPD1; IRAK-4; NY-REN-64; REN64; interleukin-1 receptor-associated kinase 4; renal carcinoma antigen NY-REN-64; EC 2.7.11.1 |
Gene ID : | 51135 |
mRNA Refseq : | NM_016123 |
Protein Refseq : | NP_057207 |
MIM : | 606883 |
UniProt ID : | Q9NWZ3 |
Products Types
◆ Recombinant Protein | ||
IRAK4-1168H | Recombinant Human IRAK4 Protein (E154-S460), Tag Free | +Inquiry |
Irak4-3570M | Recombinant Mouse Irak4 Protein, Myc/DDK-tagged | +Inquiry |
Irak4-0058M | Recombinant Mouse Irak4 protein(Ser169-Ala459), His-tagged | +Inquiry |
IRAK4-1107H | Recombinant Human IRAK4 protein(Met1-Ser336), His-tagged | +Inquiry |
IRAK4-1169H | Recombinant Human IRAK4 Protein (E154-S460), His tagged | +Inquiry |
◆ Lysates | ||
IRAK4-615HCL | Recombinant Human IRAK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.
Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.
They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.
Q&As (5)
Ask a questionRheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.
Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.
Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.
Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.
By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.
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