Recombinant Mouse Irak4 protein(Ser169-Ala459), His-tagged

• Cat.No.: Irak4-0058M
• Product Overview: Recombinant Mouse Irak4 protein(Ser169-Ala459)(Q8R4K2), fused with N-terminal His tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Mouse
• Tag: His
• Protein length: Ser169-Ala459
• Form: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
• Molecular Mass: 34.44 kDa
• Purity: >90% as determined by SDS-PAGE.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 °C for one week .Store at -20 to -80 °C for twelve months from the date of receipt.
• Reconstitution: Reconstitute in sterile water for a stock solution.

Gene Information

• Gene Name: Irak4 interleukin-1 receptor-associated kinase 4 [ Mus musculus ]
• Official Symbol: Irak4
• Synonyms: Irak4
• Gene ID: 266632
• mRNA Refseq: NM_029926
• Protein Refseq: NP_084202
• UniProt ID: Q8R4K2

Reviews

11/16/2021

Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.

03/01/2020

Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.

07/16/2018

They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

Q&As

What conditions are associated with IRAK4 dysregulation?

Rheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.

Are there any ongoing clinical trials involving IRAK4 inhibitors?

Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.

What are the methods used to target IRAK4 in treatment?

Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.

How does the expression of IRAK4 differ in healthy individuals and those with autoimmune diseases?

Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.

How does IRAK4 inhibition impact the immune response?

By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.