Active Recombinant Human IRAK4 protein, His-tagged
Cat.No. : | IRAK4-46H |
Product Overview : | Recombinant Human IRAK4(Met 1-Ser 460) fused with His tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Source : | Insect cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met |
Form : | Supplied as sterile 20mM Tris, 500mM NaCl, 0.5mM PMSF, pH 7.4 |
Bio-activity : | The specific activity was determined to be 169 nmol/min/mg using MBP as substrate. |
Molecular Mass : | The recombinant human IRAK4 consists of 478 amino acids and predicts a molecular mass of 53.8 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 92 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ] |
Official Symbol : | IRAK4 |
Synonyms : | IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64; |
Gene ID : | 51135 |
mRNA Refseq : | NM_001114182 |
Protein Refseq : | NP_001107654 |
MIM : | 606883 |
UniProt ID : | Q9NWZ3 |
Chromosome Location : | 12q12 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; interleukin-1 receptor binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
IRAK4-1169H | Recombinant Human IRAK4 Protein (E154-S460), His tagged | +Inquiry |
IRAK4-2438H | Recombinant Full Length Human IRAK4 Protein, MYC/DDK-tagged | +Inquiry |
IRAK4-2112R | Recombinant Rhesus Macaque IRAK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Irak4-3570M | Recombinant Mouse Irak4 Protein, Myc/DDK-tagged | +Inquiry |
IRAK4-5437H | Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged | +Inquiry |
◆ Lysates | ||
IRAK4-615HCL | Recombinant Human IRAK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionRheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.
Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.
Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.
Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.
By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.
Customer Reviews (3)
Write a reviewIts potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.
Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.
They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.
Ask a Question for All IRAK4 Products
Required fields are marked with *
My Review for All IRAK4 Products
Required fields are marked with *
Inquiry Basket