jak2
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  • Official Full Name
  • JAK2 Janus kinase 2
  • Synonyms
  • JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;
Cat.#:JAK2-254HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 Protein, His-tagged
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Cat.#:JAK2-5439HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, GST-tagged
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Cat.#:JAK2-5441HTag:GST/His
Source (Host):Baculovirus infected Sf9 cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, GST-His-tagged
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Cat.#:Jak2-255MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Jak2 Protein, His-tagged
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Cat.#:Jak2-257RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Jak2 Protein, His-tagged
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Cat.#:JAK2-157HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His/MBP-tagged
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Cat.#:JAK2-158HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His/MBP-tagged
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Cat.#:JAK2-2487HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human Jak2, His-tagged
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Cat.#:JAK2-250HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human JAK2
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Cat.#:JAK2-26HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human JAK2 protein, MYC/DDK-tagged
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Cat.#:JAK2-27628THTag:His
Source (Host):Species:Human
Product nameRecombinant Human JAK2, His-tagged
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Cat.#:JAK2-27629THTag:His
Source (Host):Species:Human
Product nameRecombinant Human JAK2, His-tagged
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Cat.#:JAK2-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 Protein, His-tagged
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Cat.#:JAK2-336HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human JAK2 protein, GST-tagged
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Cat.#:JAK2-532HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, His-tagged
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Cat.#:JAK2-57HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human JAK2 protein, Flag-tagged, Biotinylated
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Cat.#:JAK2-598HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His-tagged
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Cat.#:JAK2-81HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK2, GST-tagged
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Cat.#:JAK2-3136RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat JAK2 Protein
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Cat.#:JAK2-2327RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey JAK2 Protein, His-tagged
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Cat.#:JAK2-2252CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken JAK2
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Cat.#:JAK2-1420HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK2 (Active), His-tagged
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Involved Pathway

JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
EGFR; LGALS3; TIRAP; CHUK; MMP13; JAK2; JUN; MAPK14; DIAPH1; ATF2
ARMS-mediated activation
PHB; FGF20A; PSMD10; PEBP1; EGF; SPRED1; RASGEF1A; IL17RD; DUSP6; NEFLB
Adipocytokine signaling pathway
CPT1C; G6PC3; G6PC2; AKT1; NFKBIAA; PRKAB1; IKBKB; MAPK10; LEPR; ACACB
Axon guidance
FGF18B; NEFLB; SCN3A; GPC1A; SRGAP3; RNF8; RANBP9; SRGAP2; DNM2; NRP1A
BDNF signaling pathway
SYN1; EIF4EBP1; BCL2L11; DPYSL2; CDK5; EEF2; MAP3K2; CNR1; CSNK2A1P; EGR2
CXCR4-mediated signaling events
PAG1; CSK; GNB2L1; GNA13; MAPKAP1; CRK; ADRBK1; DNM1; CFL1; JAK2
Chemokine signaling pathway
FGR; CCL3; PRKCD; CXCL2; GNG4; WASL; RAF1; CCL2; GRB2; JAK2
Cholinergic synapse
PLCB2; PIK3R2; ATF4; KCNJ14; KCNJ2; GNG13; PIK3R1; PIK3R5; PRKCG; GNG7

Protein Function

JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PRKG1A; CAMK1GA; ADK; MTPAP; ATP6V1AA; KIF3C; HIPK3; MYO3A; NAIP7; BMPR2A
Function SH2 domain binding
Related Protein AFAP1L2; SIT1; MS4A2; JAK2; LAX1; NLK; SRC; DLC1; SQSTM1; GNB2L1
Function acetylcholine receptor binding
Related Protein APP; RAPSN; UBXN2A; DLG4; KCNS1; RER1; NRXN1; RIC3; JAK2
Function growth hormone receptor binding
Related Protein GH1; SOCS2; TYK2; JAK2; Gh; JAK1
Function heme binding
Related Protein NGB; HBAA; CYP4A14; NOS1; CYP2Y3; CYP2W1; HBG1; BA1; CYP4F11; HBE1
Function histone binding
Related Protein USP3; CTCFL; UHRF2; HIST1H4C; JAK2; NPM2; PHF21A; DEK; ATAD2; CHD8
Function histone kinase activity (H3-Y41 specific)
Related Protein JAK2
Function insulin receptor substrate binding
Related Protein IGF1RA; PIK3CB; IGF1RB; INSRB; PIK3R1; PRKCD; PRKCZ; PIK3CA; INSR; GRB2
Function interleukin-12 receptor binding
Related Protein JAK2; IL12A; IL12BA; IL12B
Function non-membrane spanning protein tyrosine kinase activity
Related Protein PTK2AA; LYN; CSK; JAK1; CLK1; FRK; PTK2BB; FES; MELK; SRC
Function peptide hormone receptor binding
Related Protein NPPA; PTHLH; LEP; FYN; NPPC; PTH; ADCYAP1; JAK2; RUNDC3A; PTPN11
Function phosphatidylinositol 3-kinase binding
Related Protein CALM3; INSRA; IGF1RB; CALM1; TYRO3; HCST; ATP1A1; LCK; IRS4; IGF1RA
Function protein C-terminus binding
Related Protein PDZD11; DBNL; ITGB3BP; NEIL1; CACNA1B; PPP1R9B; ATP1B1; SHANK2; SNF8; DLG1
Function protein binding
Related Protein UNC45A; BCL2L13; ARHGEF15; MOXD1; CUEDC2; IL24; KLHL12; WDR48; RSPO1; KNG1
Function protein kinase activity
Related Protein TEX14; PRKAA2; CSNK1E; WEE2; MMD; SGK2A; HIPK2; MAP4K3; CSNK1DB; CSNK1DA
Function protein kinase binding
Related Protein NGFRAP1; BCL2L1; THY1; SPRED2; TPRKB; CHEK2; GOLGA2; FGF19; DVL1; LLGL1
Function protein tyrosine kinase activity
Related Protein EK1; NTRK3A; ABL2; CSF1RA; CAMKK2; CLK4; JAK1; MAP3K9; EGFR; BMX
Function receptor binding
Related Protein CADM2; NRG4; PLAUR; TNFSF18; PARK7; PGR; AMH; PDGFRB; PIPOX; PVRL3B
Function type 1 angiotensin receptor binding
Related Protein BDKRB2; GNA13; ARRB2; GNG3; JAK2; ARAP1; GNA13B; GNB1; TYK2; GNA13A

Interacting Protein

JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.
PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

JAK2 Related Articles

Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).

JAK2 Related Gene Family

TGF Cytokines