jak2
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  • Official Full Name
  • JAK2 Janus kinase 2
  • Synonyms
  • JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;
Cat.#:JAK2-254HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 Protein, His-tagged
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Cat.#:JAK2-5439HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, GST-tagged
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Cat.#:JAK2-5441HTag:GST/His
Source (Host):Baculovirus infected Sf9 cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, GST-His-tagged
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Cat.#:Jak2-255MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Jak2 Protein, His-tagged
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Cat.#:Jak2-257RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Jak2 Protein, His-tagged
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Cat.#:JAK2-157HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His/MBP-tagged
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Cat.#:JAK2-158HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His/MBP-tagged
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Cat.#:JAK2-2487HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human Jak2, His-tagged
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Cat.#:JAK2-250HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human JAK2
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Cat.#:JAK2-26HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human JAK2 protein, MYC/DDK-tagged
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Cat.#:JAK2-27628THTag:His
Source (Host):Species:Human
Product nameRecombinant Human JAK2, His-tagged
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Cat.#:JAK2-27629THTag:His
Source (Host):Species:Human
Product nameRecombinant Human JAK2, His-tagged
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Cat.#:JAK2-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 Protein, His-tagged
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Cat.#:JAK2-336HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human JAK2 protein, GST-tagged
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Cat.#:JAK2-532HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, His-tagged
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Cat.#:JAK2-57HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human JAK2 protein, Flag-tagged, Biotinylated
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Cat.#:JAK2-598HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His-tagged
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Cat.#:JAK2-81HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK2, GST-tagged
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Cat.#:JAK2-3136RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat JAK2 Protein
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Cat.#:JAK2-2327RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey JAK2 Protein, His-tagged
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Cat.#:JAK2-2252CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken JAK2
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Cat.#:JAK2-1420HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK2 (Active), His-tagged
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Involved Pathway

JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
EGFR; MAPK14; JAK2; CHUK; AGER; JUN; LGALS3; DDOST; TIRAP; ATF2
ARMS-mediated activation
DUSP1; JAK2; PSMD5; DUSP6; DUSP10; DUSP9; SPTB; NRG4; FRS2B; WDR83
Adipocytokine signaling pathway
NFKBIAA; G6PCA.2; PTPN11A; PRKAB1B; SLC2A4; RELA; RXRGA; TNF; ADIPOR1B; MAPK10
Axon guidance
CNKSR1; ROBO3; DPYSL5B; EFNA1; EGF; RHOGA; JAK2; GNAI3; KLB; DNM1
BDNF signaling pathway
FRS2; JAK2; SIRPA; GNB2L1; KCNN2; IGF2BP1; DPYSL2; GRIP1; EGR1; LINGO1
CXCR4-mediated signaling events
ARR3; ADRBK1; PAG1; BLK; JAK2; CRK; CFL1; DNM1; MAPKAP1; CSK
Chemokine signaling pathway
GRK5; PIK3R2; RAP1B; PRKACA; NRAS; GNG7; SHC3; CCL5; LYN; NFKB1
Cholinergic synapse
CHAT; CHRNA7; Adcy4; CHRNB4; ITPR1; CREB3L3; KCNJ14; PLCB1; CREB3; AKT1

Protein Function

JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein GTF2F2B; HSPD1; ATP1A1A.5; MCCC2; ATP1A1; PTK2BB; CHD8; PAK6; RUNX3; NAV2
Function SH2 domain binding
Related Protein LILRB1; PAG1; SHCBP1; KHDRBS2; ARHGAP5; SKAP1; SRC; NLK; AFAP1L2; GNB2L1
Function acetylcholine receptor binding
Related Protein RER1; KCNS1; DLG4; NRXN1; RIC3; RAPSN; APP; JAK2; UBXN2A
Function growth hormone receptor binding
Related Protein Gh; JAK2; JAK1; TYK2; GH1; SOCS2
Function heme binding
Related Protein HRG-1; HBZ; CYP2J2; CYP2P7; CYP4F2; FAM84B; CYP2AD2; CYP11B1; CYP51A1; FECH
Function histone binding
Related Protein MYSM1; ELP2; ATAD2; HIST1H3C; PIH1D1; ANP32E; TBL1X; PRMT6; HIST2H3C1; RNF20
Function histone kinase activity (H3-Y41 specific)
Related Protein JAK2
Function insulin receptor substrate binding
Related Protein PIK3CB; PRKCZ; PIK3R1; GRB2; IGF1R; PIK3CA; INSRB; INSR; INSRR; PTPN11
Function interleukin-12 receptor binding
Related Protein JAK2; IL12A; IL12B; IL12BA
Function non-membrane spanning protein tyrosine kinase activity
Related Protein FGR; SRMS; ABL2; FYNB; TNK2; ZAP70; BLK; PTK2BB; SYK; EIF2AK2
Function peptide hormone receptor binding
Related Protein PTPN11; PTH; PTHLHA; FYN; JAK2; NPPA; PTHLH; RUNDC3A; LEP; ADCYAP1
Function phosphatidylinositol 3-kinase binding
Related Protein FYN; INSR; CALM2; TYRO3; PDGFRB; IGF1R; PIK3R1; JAK2; LCK; INSRB
Function protein C-terminus binding
Related Protein CDC20; DDX1; STIP1; SNX17; MYO1C; PEX1; LCK; HOMER3; PIAS4; TERF2
Function protein binding
Related Protein STK38; NAT8; IKBIP; ZNF69; TBL1X; PHOSPHO2; VPS37A; SLAMF7; ZNF550; RSPH9
Function protein kinase activity
Related Protein PLK2B; MAPK14A; PRKCHA; NLK2; CSNK1D; DYRK1B; GRK1B; KITB; CAMK1GB; DYRK3
Function protein kinase binding
Related Protein AGTR1A; SLC12A4; ELAVL1; CCNYL1; BCAR1; SPRY2; EEF1A1; TPRKB; VRK2; E2F1
Function protein tyrosine kinase activity
Related Protein EPHB3A; EGFRA; RET; FGFR1A; IGF1RA; CSK; TEK; MAP2K6; FYNA; MUSK
Function receptor binding
Related Protein C1QTNF2; UTS2; ACOX2; SCYL2; APLN; TMED1; RARA; ANG; ZAP70; SSFA2
Function type 1 angiotensin receptor binding
Related Protein GNA13B; GNG3; GNA13A; BDKRB2; AGT; GNA13; TYK2; ARRB2; JAK2; ARAP1

Interacting Protein

JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.
PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

JAK2 Related Articles

Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).

JAK2 Related Gene Family

TGF Cytokines