jak2
Share
  • Official Full Name
  • JAK2 Janus kinase 2
  • Synonyms
  • JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;
Cat.#:JAK2-254HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 Protein, His-tagged
+Inquiry
Cat.#:JAK2-5439HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, GST-tagged
+Inquiry
Cat.#:JAK2-5441HTag:GST/His
Source (Host):Baculovirus infected Sf9 cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, GST-His-tagged
+Inquiry
Cat.#:Jak2-255MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Jak2 Protein, His-tagged
+Inquiry
Cat.#:Jak2-257RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Jak2 Protein, His-tagged
+Inquiry
Cat.#:JAK2-157HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His/MBP-tagged
+Inquiry
Cat.#:JAK2-158HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His/MBP-tagged
+Inquiry
Cat.#:JAK2-2487HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human Jak2, His-tagged
+Inquiry
Cat.#:JAK2-250HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human JAK2
+Inquiry
Cat.#:JAK2-26HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human JAK2 protein, MYC/DDK-tagged
+Inquiry
Cat.#:JAK2-27628THTag:His
Source (Host):Species:Human
Product nameRecombinant Human JAK2, His-tagged
+Inquiry
Cat.#:JAK2-27629THTag:His
Source (Host):Species:Human
Product nameRecombinant Human JAK2, His-tagged
+Inquiry
Cat.#:JAK2-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 Protein, His-tagged
+Inquiry
Cat.#:JAK2-336HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human JAK2 protein, GST-tagged
+Inquiry
Cat.#:JAK2-532HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 2, His-tagged
+Inquiry
Cat.#:JAK2-57HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human JAK2 protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:JAK2-598HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK2 protein, His-tagged
+Inquiry
Cat.#:JAK2-81HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK2, GST-tagged
+Inquiry
Cat.#:JAK2-3136RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat JAK2 Protein
+Inquiry
Cat.#:JAK2-2327RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey JAK2 Protein, His-tagged
+Inquiry
Cat.#:JAK2-2252CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken JAK2
+Inquiry
Cat.#:JAK2-1420HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK2 (Active), His-tagged
+Inquiry

Involved Pathway

JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
CHUK; ATF2; TIRAP; JAK2; JUN; MAPK14; LGALS3; MMP13; EGFR; DIAPH1
ARMS-mediated activation
RASGRP4; AKAP9; KLB; NTF7; DAB2IPB; DUSP1; CSF2RB; SPRED1; PSME3; DUSP5
Adipocytokine signaling pathway
TNFRSF1A; SOCS3; PPARAB; G6PC; LEPA; PPARGC1A; CAMKK2; ACSL3; ADIPOQB; IRS2
Axon guidance
DUSP4; LRRC4C; SEMA6D; MYL9; EPHA5; CREB1B; EFNA3; COL4A5; NTN1; DCC
BDNF signaling pathway
DPYSL2; CDKL5; IGF2BP1; MAP3K2; EGR1; CDK5; EIF4EBP1; CNR1; CDH2; GNB2L1
CXCR4-mediated signaling events
PAG1; ADRBK1; GNA13; BLK; GNB2L1; CFL1; JAK2; MAPKAP1; CRK; ARR3
Chemokine signaling pathway
GSK3B; RLN1; FOXO3; CCL4L2; PIK3CB; CXCL5; Ccl21a; PXN; Ccl12; GM13304
Cholinergic synapse
PRKCB; PIK3R1; CHRNB2; GNG2; CHRM3; CAMK2D; KCNJ3; AKR1C1; CHRM4; CREB3

Protein Function

JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PL10; CARKD; PDXK; PARS2; ACACA; LONP1; AK7A; UBE2L3; MAP3K2; CSNK2A1
Function SH2 domain binding
Related Protein SKAP1; SQSTM1; SHCBP1; IRS1; LILRB1; DLC1; LAX1; MS4A2; SIT1; PAG1
Function acetylcholine receptor binding
Related Protein NRXN1; UBXN2A; JAK2; KCNS1; APP; RER1; RAPSN; DLG4; RIC3
Function growth hormone receptor binding
Related Protein JAK1; JAK2; SOCS2; GH1; Gh; TYK2
Function heme binding
Related Protein CYBA; GUCY1B3; Adgb; CYP2AA1; CYP51A1; PTGES2; CYP2C8; LPO; CYP2C9; CYP2D10
Function histone binding
Related Protein HIST1H3C; DEK; HIST1H3E; MYSM1; HAT1; TBL1X; DAXX; PHF21B; HIST1H4D; SERPINB1A
Function histone kinase activity (H3-Y41 specific)
Related Protein JAK2
Function insulin receptor substrate binding
Related Protein PIK3CB; INSRA; INSR; IGF1R; JAK2; PTPN11; PRKCZ; IGF1RA; PIK3CA; IGF1RB
Function interleukin-12 receptor binding
Related Protein IL12BA; JAK2; IL12B; IL12A
Function non-membrane spanning protein tyrosine kinase activity
Related Protein JAK2B; RIPK2; YRK; FYNB; MELK; Fert2; PTK2B; PTK2; ZNF143B; TNK1
Function peptide hormone receptor binding
Related Protein PTHLH; LEP; PTPN11; PTH; PTHLHA; ADCYAP1; NPPA; JAK2; FYN; RUNDC3A
Function phosphatidylinositol 3-kinase binding
Related Protein BECN1; IGF1RA; TYRO3; IRS2; IGF1R; HCST; IRS4; PDGFRB; CORO1A; INSRB
Function protein C-terminus binding
Related Protein XRCC5; C11orf60; CEP120; MIF4GD; PCGF1; CEP135; CTNNB1; SDCBP; YEATS4; NPAT
Function protein binding
Related Protein APBB2; SLX4; ARNTL1B; AP4B1; NUP54; MMP20; PDE4D; TXNRD1; GBAS; AIFM1
Function protein kinase activity
Related Protein CCL2; SGK2B; RLN1; TEK; CSNK1G2B; PLK5; MAP2K5; PAK4; DAPK1; CDK9
Function protein kinase binding
Related Protein IKBKB; CCNYL1; DPYSL2; RFFL; CDH2; PIFO; TCTN2; GDF3; FAF1; FER
Function protein tyrosine kinase activity
Related Protein MATK; ZAP70; JAK2; KITB; PTK2B; JAK3; FGFR3; PTK2AB; TYK2; EGFRA
Function receptor binding
Related Protein ADCYAP1; FGF6B; CD276; SRC; WNT11R; TRDN; HAO2; C5; FGF12B; SERPINE2
Function type 1 angiotensin receptor binding
Related Protein GNA13B; GNA13; GNB1; AGT; JAK2; ARRB2; BDKRB2; TYK2; GNG3; ARAP1

Interacting Protein

JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.
PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

JAK2 Related Articles

Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).

JAK2 Related Gene Family

TGF Cytokines